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Giacon, Marta (2008) Palaeopathology in the Osteological Collection of Anthropological Museum in Padova University: the cases of tuberculosis. [Tesi di dottorato]

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Abstract (inglese)

Many evidence confirm that tuberculosis (TB) has been a constant disease of man throughout all his history. Moreover, till now it is one of the most important and dangerous diseases that are presently undergoing re-emergence: each year the number of new cases and the appearance of multiresistant tubercle bacilli are constantly increasing. Although human TB, principally caused by two members (M. bovis and M. tuberculosis) of the pathogenic Mycobacterium tuberculosis complex, is primarily the involvement a soft tissue infection, clinical data show skeletal involvement: for extrapulmonary TB, the rates for all osseous changes range from 1% to 9% (data from various authors reported by Santos, 2001), in the pre-antibiotic era the incidence of skeletal involvement is calculated in average 5-7% (Steinbock, 1976).
The characteristic bone alterations in tuberculosis are the consequence of the development of granulation tissue, with a specific tropism for the richly vascularized sites. The diagnosis of TB in archeological human remains relies on the analysis of disease expression: lesion morphology, location and skeletal pattern.
The skeletal alterations that actually are connected with tuberculosis can be gathered in “classical TB alterations” and in “MOLAT’, (“Minor Osseous Lesions Attributable to Tuberculosis”). The first group consists of characteristic alterations for which there are several clinical and paleopathological literature and osteological collections as referred: they represent TB skeletal changes already in developed stage. The second group of lesions (MOLAT) analyzes the early stages of disease to identify some diagnostic criteria to recognize it, and they don’t have the general consensus of all authors. In particular, the MOLAT characteristics are periosteal appositions on the visceral surface of ribs, endocranial changes, hypervascularization of vertebrae and hypertrophic osteoarthropaty.
The present work studies a small osteological collection (Tedeschi Osteological Collection, T.O.C, of University of Padova, Italy), which was collected with didactical purposes in the years from the end of 19th century to the early 20th century in which cause of death, age at death and job are registered. This collection could be a potential source of information, but it was unknown till now. The aim of the present study is to recover this collection analyzing the TB remains looking for the classical alterations and the MOLAT. Using classical morphological anthropology, histology, radiology, molecular biology and densitometry of bone tissue, we try to confirm the various diagnostic criteria. Furthermore, this work, based on data arising before antibiotics became available for treatment, might contribute to the future diagnosis of TB or other pathologies in non-documented skeletal material.
We have organized a work schedule with different exams to carry out in each individual recovered. This work form includes several aspects: individualization of remains, morphological study of diseases, histological and molecular analyses, bone density determination, and radiological exams.
The individualization of remains, concerning sex, age, state of preservation and type of bone, was processed in all remains with the method of classical anthropology. Morphological study of diseases was the following stage of search. The pathological conditions were observed in the bones, looking at osseous diseases and particular infectious conditions. Histological analyses are processed in several cases. The osteological remains had been boiled and collocated in an unsuitable place and used for uncontrolled proposes: the thaphonomic processes occurred were unclear and extremely difficult to define. Six samples, randomly selected, were processed searching for DNA traits of Mycobacteria, although as remembered, the osteological collection was used by different researchers during these years and the perfect idea of a “virgin bone”, as many authors crave, is very distant to our sample situation. The densitometer is provided with a data base that allows comparison of the measured bone mineral content of an individual with that of a referral population. The data base of instrument was generated in vivo from healthy patients of both sexes. The machine used is called MatriScan, with a test totally not invasive, extremely quick and no special arrangements or training are required. Unfortunately, this is the first time that this new technique is used on osteological remains, thus similar data are not available to compare the results. Finally, the X-ray imaging is used in few ambiguous singular cases.
During this research, for the first time T.O.C. was ordered and analyzed with traditional and modern techniques, about 60 individual forms have been completed and presented.
Some characteristic TB evidences, that are part of MOLAT, have been studied for their diagnostic value. Our results could support the idea that vertebral hypervascularization is caused by TB disease: in T.O.C. sample it is associated with other typical TB evidences and it has been found in 53% of total spines and in 63% of spines with pathological evidences. In T.O.C. samples, only 31% of individuals recovered with ribs show periostitis. This result can not support the sure evidence that periostitis is caused by TB, according to Pfeiffer (1991) who claimed that it could rather be interpreted as a non-specific indicator of chronic respiratory disease stress.
The histological analyses emphasized several unknown aspects concerning histology of ancient remains, i.e. the remodelling shown with haematoxylin- eosin and tricromic stain technique.
The molecular tests demonstrate the presence of mycobacterium on the osteological samples analyzed, although they were partial and limited as state before.
Densitometry with the new technique of MetriScan appears a potential instrument for further investigations.
Many considerations were formulated to create the basis for further and deepened investigations not only to study TB individuals, but also to amplify the study with other skeletal pathologies described as causes of death (i.e. syphilis). In particular, molecular and morphological analyses should be furtherly considered.

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Tipo di EPrint:Tesi di dottorato
Relatore:Drusini, Andrea
Dottorato (corsi e scuole):Ciclo 20 > Scuole per il 20simo ciclo > SCIENZE MEDICHE, CLINICHE E SPERIMENTALI > SCIENZE CARDIOVASCOLARI
Data di deposito della tesi:30 Settembre 2008
Anno di Pubblicazione:30 Settembre 2008
Parole chiave (italiano / inglese):Palaeopathology, tuberculosis, osteological remains
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze Medico Diagnostiche e Terapie Speciali
Codice ID:1146
Depositato il:30 Set 2008
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1. Ambrose S. H. and Krigbaum J., 2003, Bone chemistry and bioarchaeology. Journal of Anthropological Archaeology, 22: 193-199. Cerca con Google

2. Arriaza B. T., Wilmar S., Aufderheide A. C. and Holcomb T. A., 1995, Pre-Columbian tuberculosis in Northern Chile: Molecular and skeletal evidence. American Journal of Physical Anthropology, 98 (1): 37-45. Cerca con Google

3. Ascenzi A. and Mottura G., 1976, Trattato di Anatomia Patologica per il medico pratico. Vol. II, ed. UTET. p. 1510-1515. Cerca con Google

4. Aufderheide A. C. and Rodríguez-Martin C., 1998, The Cambridge Encyclopedia of Human Paleopathology. Cambridge University Press, pp. 478. Cerca con Google

5. Barnes E., 2005, Diseases and Human Evolution. University of New Mexico Press. Chapter IX. Cerca con Google

6. Barnes I. and Thomas M. G., 2006, Evaluating bacterial pathogen DNA preservation in museum osteological collection. Proceedings of the Royal Society, 273: 645-653. Cerca con Google

7. Baron H., Hummel S. and Herrmann B., 1996, Mycobacterium tuberculosis Complex DNA in Ancient Human Bones. Journal of Archaeological Science, 23: 667-671. Cerca con Google

8. Bass W. M., 1987, Human Osteology. A Laboratory and Field Manual. Missouri Archaeological Society, Special Publication, pp. 310. Cerca con Google

9. Bathurst R. R. and Barta J. L., 2004, Molecular evidence of tuberculosis induced hypertrophic osteopathy in a 16th-century Iroquoian dog. Journal of Archaeological Science, 31: 917–925. Cerca con Google

10. Bellamy R., Ruwende C., Corrah T., MAcAdam K. P. W. J., Wittle H. C. and Hill A., 1998, Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. The New England Journal Medicine, 338: 640-644. Cerca con Google

11. Bigi A., Cojazzo G., Panzavolta S., Ripamonti A., Roveri N., Romanello M., Noris Suarez K. and Moro L., 1997, Chemical and Structural Characterization of the Mineral Phase from Cortical and Trabecular Bone. Journal of Inorganic Biochemistry, 68: 45-51. Cerca con Google

12. Bouwman A. S. and Brown T. A., 2005, The limits of biomolecular palaeopathology: ancient DNA cannot be used to study venereal syphilis. Journal of Archaeological Science, 32: 703-713. Cerca con Google

13. Buikstra J. E., 1976, The Caribou Eskimo: General and specific disease. American Journal of Physical Anthropology, 45 (3): 351-367. Cerca con Google

14. Campillo D., 1994(a), Paleopatología. Los primeros vestigios de la enfermedad. Primera parte. Colección Histórica de Ciencias de la Salud/n.4. Fundación Uriach 1838, pp. 167. Cerca con Google

15. Campillo D., 1994(b), Paleopatología. Los primeros vestigios de la enfermedad. Segunda parte. Colección Histórica de Ciencias de la Salud/n.5. Fundación Uriach 1838, pp. 123. Cerca con Google

16. Canci A., Minozzi S. and Borgognini S., 1996, New evidence of tuberculous spondylitis from Neolithic Liguria (Italy). International Journal of Osteoarchaeology, 6: 497-51. Cerca con Google

17. Capasso L., Verginelli F., Caramiello S., Palmirotta R., D’Anastasio R. And Mariani-Costantini R., 1999, Identificazione e diagnosi molecolare di condizioni patologiche in reperti scheletrici umani antichi. In Rollo F., (ed.), Il DNA nello studio dei resti umani antichi. Medical Books, pp. 104. Cerca con Google

18. Capasso L., 2001, I fuggiaschi di Ercolano. Paleobiologia delle vittime dell’eruzione vesuviana del 79 d.C. Roma:”L”ERNA” di Bretschneider”, pp. 1089. Cerca con Google

19. Capasso L., 2002, Principi di Storia della Patologia Umana. Roma: SEU. Cerca con Google

20. Caramelli D. and Lari M., 2004, Il DNA antico. Angelo Pontecorboli Editore, pp. 160. Cerca con Google

21. Clarke N. G. and Hirsh R. S., 1991, Physiological, Pulpal, and Periodontal Factors Influencing Alveolar Bone. In: Kelly M. A. and Larsen C. S., 1994, (ed.), Advances in Dental Anthropology. Wiley-Liss, Inc., New York, N.Y., p 241-266. Cerca con Google

22. Cohen M. N., Wood J. W. and Milner G. R., 1994, The Osteological Paradox Reconsidered. Current Anthropology, 35 (5): 629. Cerca con Google

23. Consensus Conference, 2001, Osteoporosis Prevention, Diagnosis, and Therapy. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. JAMA, February 14, 285 (6): 785-795. Cerca con Google

24. Cook S. M., Bartos R. E., Pierson C. C. and Frank T. S., 1994, Detection and characterization of atypical Mycobacteria by the polymerase chain reaction. Diagnostic Molecular Pathology, 3 (1): 53-58. Cerca con Google

25. Corrain C., 1988, Emilio Tedeschi: 1860-1931. Antropologia Contemporanea, 11 (1-2): 76-77. Cerca con Google

26. Cox M., 2000, Ageing adults from the skeleton. In Cox M. & Mays S. (eds), Human Osteology in Archaeology and Forensic Science. Greenwich Medical Media Ltd., pp.522. Cerca con Google

27. Daniel T. M., 2000, The origins and pre-colonial epidemiology of tuberculosis in the Americas: can we figure them out International Journal Tubercle and Lung Disease, 4: 395–400. Cerca con Google

28. Dastugue J. and Gervais V., 1992, Paleopathologie du squelette humain. Société Nouvelle Des Éditions Boubée, Paris, pp. 253. Cerca con Google

29. Denys C., 2002, Taphonomy and Experimentation. Archaeometry, 44 (3): 469-484. Cerca con Google

30. Finnegan M., 1978, Non metric variation of the infra-cranial skeleton. Journal of Anatomy, 125: 23-37. Cerca con Google

31. Fletcher H. A., Donoghue H. D., Taylor G. M., van der Zanden A. G. M. and Spigelman M., 2003, Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians. Microbiology, 149: 143-151. Cerca con Google

32. Freeth C., 2000, Dental health in British antiquity. In Cox M. & Mays S. (eds), Human Osteology in Archaeology and Forensic Science. Greenwich Medical Media Ltd., p. 522. Cerca con Google

33. Frieden T. R., Sterling T. R., Munsiff S. S., Watt C., J. and Dye C., 2003, Tuberculosis. The Lancet; 362: 887-899. DOI: 10.1016/S0140-6736(03)14333-4. Cerca con Google

34. Fornaciari G., 2008, Appunti di “Paleopatologia” a.a.2005/2006. Web Site Vai! Cerca con Google

35. Goldfeld A. E., Delgado J. C., Thim S., Bozon M. V., Uglialoro A. M., Turbay D., Cohen C., and Yunis E. J., 1998, Association of an HLA-DQ allele with clinical tuberculosis. Journal American Medical Association, 279: 226-228. Cerca con Google

36. Goodman A. H., Armelagos G. J., and Rose J. C., 1980, Enamel Hypoplasia as Indicators of stress in three prehistoric populations from Illinois. Human Biology, 52 (3): 515-528. Cerca con Google

37. Grauer A. L., (ed.), 1995, Bodies of evidence. Reconstructing history through skeletal analysis. Wiley-Liss, Inc., USA, pp.147. Cerca con Google

38. Haas C. J., Zink A., Molnar E., Szeimies U., Reischl U., Marcsik A., Ardagna Y., Dutour O., Pálfi G., and Nerlich A. G., 2000, Molecular Evidence for Different Stages of Tuberculosis in Ancient Bone Samples from Hungary. American Journal of Physical Anthropology, 113: 293–304. Cerca con Google

39. Haglund W. D. and Sorg M. H. (eds.), 1997, Forensic Taphonomy. The Postmortem Fate of Human Remains. CRC Press LLC, USA, pp. 636. Cerca con Google

40. Haglund W. D. and Sorg M. H. (eds.), 2002, Advances in Forensic Taphonomy. CRC Press LLC, USA, pp. 507. Cerca con Google

41. Hauser G. and De Stefano G.F. (eds), 1989, Epigenetic Variants of the Human Skull. Schweizerbart-Stuttgart, pp.301. Cerca con Google

42. Hershkovitz I., Greenwald C. M., Latimer B., Lyman M. J., Wish-Baratz, S., Eshed V., Dutour O. and Rothschild B. M., 2002, Serpens Endocrania Symmetrica (SES): A New Term and a Possible Clue for Identifying Intrathoracic Disease in skeletal Populations. American Journal of Physical Anthropology,118: 201-216. Cerca con Google

43. Hedges R. E. M., 2002, Bone diagenesis: an overview of processes. Archaeometry, 44 (3): 319–328. Cerca con Google

44. Hill A. V. S., Sanchez-Mazas A., Barbujani G., Dunston G., Excoffier L., Hancock J., Klein J., Meyer U. A., Motulsky A. G., Presiuttini S., Wishart W. L. and Langaney A., 1999, Human genetic variation and its impact on public health and medicine. In Stearns C. Stephen (ed.), Evolution in Health & Disease. Oxford University Press, pp.62-77. Cerca con Google

45. Hillson S., 1996, Dental Anthropology. University Press, Cambridge, U.K., pp. 373. Cerca con Google

46. Hunt D. R. and Albanese J., 2005, History and Demographic Composition of the Robert J. Terry Anatomical Collection. American Journal of Physical Anthropology, 127: 406-417. Cerca con Google

47. Hunt D. R., 2008, The Robert J. Terry Anatomical Skeletal Collection. Web Site of Smithsonian National Museum of Natural History, Vai! Cerca con Google

48. Hrdli ka A., 1937, Biographical Memoir of George Sumner Huntington. Presented to the Academy at the Annual Meeting. National Academy of Sciences, Biographical Memoirs, Vol. XVIII – Eleventh Memoir. Cerca con Google

49. Kelley M. A. and El-Najjar M., 1980, Natural Variation and Differential Diagnosis of Skeletal Changes in Tuberculosis. Americal Journal of Physical Anthropology, 52: 153-167. Cerca con Google

50. Kelley M. A. and Micozzi M. S., 1984, Rib lesions in chronic pulmonary tuberculosis. American Journal Physical Anthropology, 65: 381-386. Cerca con Google

51. Kelly M. A. and Larsen C. S., 1994, (ed.), Advances in Dental Anthropology. Wiley-Liss, New York, N.Y., p 389. Cerca con Google

52. Langsjoen O., 1998, Diseases of the dentition. In: Aufderheide A. C. and Rodriguez-Martin C., The Cambridge Encyclopedia of Human Paleopathology. Cambridge University Press, pp.478. Cerca con Google

53. Lichetenstein L., 1976, Malattie delle ossa e delle articolazioni. Verducci Editore, pp. 328. Cerca con Google

54. Mackowiak P. A., Tiesler Blos V., Aguilar M. and Buikstra E. J., 2005, On the Origin of American Tuberculosis. Clinical Infectious Diseases, 41: 515–8. Cerca con Google

55. Maczel M., 2003, On the traces of tuberculosis. Diagnostic criteria of tuberculous affection of the human skeleton and their application in Hungarian and French Anthropological Series. PhD Thesis, University of La Méditerranée – France and University of Szeged – Hungary. Cerca con Google

56. Marcsik A., Molnár E. and Szathmáry L., 2006, The antiquity of tuberculosis in Hungary: the skeletal evidence Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 101 (Suppl. II): 67-71. Cerca con Google

57. Marson P. and Rippa Bonati M., 2003, Paleopatoloiga Reumatologica Oggi. Reumatismo, 55 (1): 1-4. Cerca con Google

58. Mays S. and Cox M., 2000, Sex determination iin skeletal remains. In Cox M. & Mays S. (eds), Human Osteology in Archaeology and Forensic Science. Greenwich Medical Media Ltd., pp. 522. Cerca con Google

59. Mays S., Taylor G. M., Legge A.J., Young D.B. and Turner-Walker G., 2001, Paleopathological and biomolecular study of tuberculosis in a medieval skeletal collection from England. American Journal of Physical Anthropology, 114 (4): 298-311. Cerca con Google

60. Mays S. and Taylor G. M., 2002, Investigation of the link between visceral surface rib lesions and tuberculosis in a medieval skeletal series from England using ancient DNA. American Journal of Physical Anthropology, 119: 27-36. Cerca con Google

61. Mays S., 2008, Radiography and Allied Techniques in the Palaeopathology of Skeletal Remains. In: Pinhasi R. and Mays S., 2008, (eds) Advances in human Paleopathology. John Wiley & Sons Ltd., England. pp. 389. Cerca con Google

62. Mohammadi A. and Howell J. M., 2007, Sternal tuberculosis. The Journal of Emergency Medicine, Oct. 31 Cerca con Google

63. Nowell A. and d’Errico F., 2007, The Art of Taphonomy and the Taphonomy of Art: Layer IV, Molodova I, Ukraine. Journal of Archaeological Method and Theory, 14 (1): 1-26. Cerca con Google

64. Ogden A., 2008, Advances in the Palaeopathology of Teeth and Jaws. In: Pinhasi R. and Mays S. (eds), Advances in human Paleopathology. John Wiley & Sons Ltd., West Sussex, England. pp. 389 Cerca con Google

65. Ortner D. J., 2008, Differential Diagnosis of Skeletal Lesions in Infectious Disease. In: Pinhasi R. and Mays S. (eds), Advances in human Paleopathology. John Wiley & Sons Ltd., West Sussex, England, pp. 389. Cerca con Google

66. Ortner D. J. and Putschar W. G. J., 1985, Identification of Pathological Conditions in Human Skeletal Remains. Smithsonian Institution Press Washington D.C., pp. 488. Cerca con Google

67. O'Rourke D. H.,. Geoffrey H. M. and Shawn W C., 2000, Ancient DNA Studies in Physical Anthropology. Annual Review of Anthropology, 29: 217-242. Cerca con Google

68. Peck J. J. and Stout S. D., 2007, Intraskeletal Variability in Bone Mass. American Journal of physical Anthopology, 132: 89-97. Cerca con Google

69. Pijoan C. MA., Mansilla J., Leboreiro I., Lara V.H. and Bosch P., 2007, Thermal alterations in archaeological bones. Archaeometry, 49 (4): 713-727. Cerca con Google

70. Pinhasi R. and Mays S., 2008, (eds) Advances in human Paleopathology. John Wiley & Sons Ltd., West Sussex, England. pp. 389. Cerca con Google

71. Rizzi J., 2008, Web Site Vai! Cerca con Google

72. Roberts C, Lucy D. and Manchester K. 1994, Inflammatory lesions of ribs: an analysis of the Terry Collection. American Journal Physical Anthropology, 95: 169–182. Cerca con Google

73. Roberts C. A., Boylston A., Buckley L., Chamberlain A. C. and Murphy E. M., 1998, Rib lesions and tuberculosis: the palaeopathological evidence. Tubercle and Lung Disease, 79 (1): 55–60. Cerca con Google

74. Roberts C., 2000, Infectious disease in biocultural perspective: past, present and future work in Britain. In Cox M. & Mays S. (eds), Human Osteology in Archaeology and Forensic Science. Greenwich Medical Media Ltd., pp. 522. Cerca con Google

75. Roberts C. and Manchester K., 2001, The archaeology of disease Second Edition, Sutton Publishing, pp. 243. Cerca con Google

76. Roberts C. A. and Buiksta J. E., 2003, The bioarchaeology of tuberculosis. A Global View on a Reemerging Disease. University Press of Florida, U.S.A., pp. 343. Cerca con Google

77. Roberts S. J., Smith C. I., Millard A. and Collins M. J., 2002 The taphonomy of cooked bone: characterizing boiling and its physico-chemical effects. Archaeometry, 44 (3): 485-494. Cerca con Google

78. Rocha M. A., 1995, Les collections ostéologiques humaines identifiées du Musée Anthropologique de l’Université de Coimbra. Antropol Port 13: 7-38. Cerca con Google

79. Rogers J. and Waldron T., 1995, A field Guide to Joint Disease in Archaeology. John Wiley & Sons Ltd, pp.119. Cerca con Google

80. Roschger P., Fratzl P., Eschberger J., and Klaushofer K., 1998, Validation of Quantitative Backscattered Electron Imaging for the Measurement of Mineral Density Distribution in Human Bone Biopsies. Bone, 23 (4): 319–326. Cerca con Google

81. Roschger P., Paschalis E. P., Fratzl, P. and Klaushofer K., 2007, Bone mineralization density distribution in health and disease. Bone, 42 (3):456-66. Cerca con Google

82. Sandison A. T., 1967, Sir Marc Amand Ruffer (1959-1917): pioneer of palaeopathology. Medical History, April, 11 (2): 150-156. Cerca con Google

83. Santos A. L. and Roberts C. A., 2001. A picture of tuberculosis in young Portuguese people in the earlier 20th century. A multidisciplinary study of the skeletal and historical evidence. American Journal of Physical Anthropology, 115: 38-49. Cerca con Google

84. Santos A. L. and Roberts C. A., 2006, Anatomy of a serial killer: Differential diagnosis of tuberculosis based on rib lesions of adult individuals from the Coimbra identified skeletal collection, Portugal. American Journal of Physical Anthropology, 130, (1):38-49. Cerca con Google

85. Sartori L., Orlando M.R., Musacchio E., Silva-Netto F., Maggi S., Realdi G., 2006. Radiographic absorptiometry as a pre-screening approach for the osteoporotic patient’s evaluation. International Society for Clinical Densitometry Annual Meeting, San Diego (USA), feb 1-4, 2006: 196, B49. Cerca con Google

86. Schultz M., 2001, Paleohistopathology of Bone: A New Approach to the Study of Ancient Diseases. Yearbook of Physical Anthropology, 44:106–147. Cerca con Google

87. Stead W. W., Senner J. W., Reddick W. T. and Lofgren J. P., 1990, Racial differences in susceptibility to infection by Mycobacterium tuberculosis. The New England Journal Medicine, 322: 422-427. Cerca con Google

88. Stearns C. S. (ed.), 1999, Evolution in Health & Disease. Oxford University Press, pp. 328. Cerca con Google

89. Steele D. G. and Bramblett C. A., 2000, The Anatomy and Biology of the Human Skeleton. Texas A&M University Press, pp. 10-19. Cerca con Google

90. Steinbock R. T., 1976, Paleopathological diagnosis and interpretation. Bone diseases in acient human population. Charles C. Thomas Publisher – Springfield Illinois, pp. 170-190. Cerca con Google

91. Stirlanda A. and Waldron T., 1990, The earliest cases of tuberculosis in Britain. Journal of Archaeological Science, 17 (2): 221-230. Cerca con Google

92. Sorg M. H. and Haglund W. D., 2002, Advancing Forensic Taphonomy: Purpose, Theory and Process. In: Haglund W. D. and Sorg M. H. (eds.), Advances in Forensic Taphonomy. CRC Press LLC, USA, pp. 507. Cerca con Google

93. Sousa A. O., Salem J. I., Lee F. K., Verçosa M. C., Cruaud P., Bloom B. R., Lagrange P. H., and David H. L.,1997, An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon. Proceedings of the National Academy of Sciences of the United States of America, USA, Medical Sciences, 94: 13227–13232. Cerca con Google

94. Suzuki T., Fujita H. and Choi J. G., 2008, Brief Communication: New Evidence of Tuberculosis From Prehistoric Korea-Population Movement and Early Evidence of Tuberculosis in Far East Asia. American Journal of Physical Anthropology, 136 (3): 357-360. Cerca con Google

95. Taylor M. G., Goyal M., Legge A. J., Shaw R. J., and Young D., 1999, Genotypic analysis of Mycobacterium tuberculosis from medieval human remains. Microbiology, 145: 899 – 904. Cerca con Google

96. The Cleveland Museum of Natural History, 2006, History of the Hamann-Todd Osteological Collection., Web Site of Section of Physical Anthropology Vai! Cerca con Google

97. The UniProt Consortium, The Universal Protein Resource (UniProt) Nucleic Acids Researce, 35: 193-197. Cerca con Google

98. University of Toronto, 2001, A Brief History of Anthropology at University of Toronto, Web Site University of Toronto, Department of Anthropology, Vai! Cerca con Google

99. van Crevel R., Ottenhoff T. H. M. and van der Meer1 J. W. M., 2002, Innate Immunity to Mycobacterium tuberculosis. Clinical Microbiology Reviews, 15 (2): 294–309. Cerca con Google

100. Waldron H. A., 2000, The study of the human remains from Nubia: the contribution of Grafton Elliot Smith and his colleagues to palaeopathology. Medical History, 44 (3): 363-388. Cerca con Google

101. Waldron Tony and Rogers Juliet, 1990, An Epidemiologic Study of Sacroiliac Fusion in Some Human Skeletal Remains. American Journal of Physical Anthropology, 83:123-127. Cerca con Google

102. White T. D. and Folkens P. A., 2005, The Human bone Manual. Elsevier Academic Press, p. 464. Cerca con Google

103. White T. D. and Folkens P. A., 2000, Human Osteology. Academic Press, USA, 563. Cerca con Google

104. Whittaker D., 2000, Ageing from the dentition. In Cox M. & Mays S. (eds), Human Osteology in Archaeology and Forensic Science. Greenwich Medical Media Ltd., p. 522. Cerca con Google

105. Wood J. W., Milner G. R., Harpending H. C., and Weiss K. M., 1992, The Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples. Current Anthropology 33 (4): 343-370. Cerca con Google

106. Wilkinson R. J, Llewelyn M., Tossi Z., Patel P., Pasvol G., Lalvani A., Wright D., Latif M. and Davidson R. N., 2000, Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. The Lancet, 355 (9204): 618-621. Cerca con Google

107. Yerramshetty J.S. and Akkus O., 2007, The associations between mineral crystallinity and the mechanical properties of human cortical bone. Bone, 42 (3): 476-482. Cerca con Google

108. Zimmerman M. R and Kelly M. A. (eds.), 1982, Atlas of Human Paleopathology. Praeger Publishers, New York. Cerca con Google

109. Zink A. R., Sola C., Reischl U., Grabner, W., Rastogi N., Hans Wolf, and Nerlich A. G., 2003, Characterization of Mycobacterium tuberculosis Complex DNAs from Egyptian Mummies by Spoligotyping. Journal of Clinical Microbiology, 41: 359-367. Cerca con Google

110. Zink A. R., Grabner W. and Nerlich A. G, 2005, Molecular identification of human tuberculosis in recent and historic bone tissue samples: The role of molecular techniques for the study of historic tuberculosis. American Journal of Physical Anthropology, 126 (1): 32-47. Cerca con Google

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