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Silvestri, Erica (2018) Simultaneous PET/MRI for Connectivity Mapping: Quantitative Methods in Clinical Setting. [Ph.D. thesis]

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In recent years, the study of brain connectivity has received growing interest from neuroscience field, from a point of view both of analysis of pathological condition and of a healthy brain. Hybrid PET/MRI scanners are promising tools to study this complex phenomenon. This thesis presents a general framework for the acquisition and analysis of simultaneous multi-modal PET/MRI imaging data to study brain connectivity in a clinical setting. Several aspects are faced ranging from the planning of an acquisition protocol consistent with clinical constraint to the off-line PET image reconstruction, from the selection and implementation of methods for quantifying the acquired data to the development of methodologies to combine the complementary information obtained with the two modalities. The developed analysis framework was applied to two different studies, a first conducted on patients affected by Parkinson’s Disease and dementia, and a second one on high grade gliomas, as proof of concept evaluation that the pipeline can be extended in clinical settings.


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EPrint type:Ph.D. thesis
Tutor:Bertoldo , Alessandra
Ph.D. course:Ciclo 30 > Corsi 30 > INGEGNERIA DELL'INFORMAZIONE
Data di deposito della tesi:13 December 2018
Anno di Pubblicazione:2018
Key Words:Positron emission tomography, functional magnetic resonance imaging, resting state, multi-modal PET/MRI, functional connectivity, structural connectivity, amyloid load
Settori scientifico-disciplinari MIUR:Area 09 - Ingegneria industriale e dell'informazione > ING-INF/06 Bioingegneria elettronica e informatica
Struttura di riferimento:Dipartimenti > Dipartimento di Ingegneria dell'Informazione
Codice ID:11601
Depositato il:06 Nov 2019 12:43
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