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Redaelli, Marco and Cavaggioni, Andrea and Mucignat-Caretta, Carla and Cavirani, Sandro and Caretta, Antonio and Donofrio, Gaetano (2008) Transduction of the rat brain by Bovine Herpesvirus 4. [Online journal papers]

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Abstract (english)

Bovine herpesvirus 4 (BoHV-4) is a gamma-herpesvirus with no clear disease association. A recombinant BoHV-4 (BoHV-4EGFP?TK) expressing Green Fluorescent Protein (EGFP), was successfully used to infect F98 rat glioma cells. BoHV-4EGFP?TK was injected into the lateral ventricle of the rat brain. Histology and immunohistochemistry showed that ependymal and rostral migratory stream cells were transduced while neurons were not. Clinical scores, evaluated for 90 days, indicated that the virus was non neuropathogenic, suggesting this virus is a suitable vector for brain tumor gene therapy.


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EPrint type:Online journal papers
Anno di Pubblicazione:2008
Key Words:Bovine herpesvirus 4, rat brain
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/26 Neurologia
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Anatomia e Fisiologia Umana
Codice ID:1174
Depositato il:09 Dec 2008
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