Vai ai contenuti. | Spostati sulla navigazione | Spostati sulla ricerca | Vai al menu | Contatti | Accessibilità

| Crea un account

Ferrari, Francesco - Bortoluzzi, Stefania - Coppe, Alessandro - Basso, Dario - Bicciato, Silvio - Zini, Roberta - Gemelli, Claudia - Danieli, Gian Antonio - Ferrari, Sergio (2007) Genomic expression during human myelopoiesis. [Articolo di periodico (online)]

Full text disponibile come:

[img]
Anteprima
Documento PDF
707Kb

Per gentile concessione di: http://www.biomedcentral.com/1471-2164/8/264

Abstract (inglese)

Background

Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This study aimed at investigating the genomic expression during myeloid differentiation through a computational approach that integrates gene expression profiles with functional information and genome organization.

Results

Gene expression data from 24 experiments for 8 different cell types of the human myelopoietic lineage were used to generate an integrated myelopoiesis dataset of 9,425 genes, each reliably associated to a unique genomic position and chromosomal coordinate. Lists of genes constitutively expressed or silent during myelopoiesis and of genes differentially expressed in commitment phase of myelopoiesis were first identified using a classical data analysis procedure. Then, the genomic distribution of myelopoiesis genes was investigated integrating transcriptional and functional characteristics of genes. This approach allowed identifying specific chromosomal regions significantly highly or weakly expressed, and clusters of differentially expressed genes and of transcripts related to specific functional modules.

Conclusion

The analysis of genomic expression during human myelopoiesis using an integrative computational approach allowed discovering important relationships between genomic position, biological function and expression patterns and highlighting chromatin domains, including genes with coordinated expression and lineage-specific functions.
Background


Statistiche Download - Aggiungi a RefWorks
Tipo di EPrint:Articolo di periodico (online)
Anno di Pubblicazione:2007
Parole chiave (italiano / inglese):Human myelopoiesis, cellular, genomic expression
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/03 Genetica medica
Struttura di riferimento:Dipartimenti > Dipartimento di Biologia
Dipartimenti > Dipartimento di Processi chimici dell'Ingegneria
Codice ID:1187
Depositato il:09 Dic 2008
Simple Metadata
Full Metadata
EndNote Format

Download statistics

Solo per lo Staff dell Archivio: Modifica questo record