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Bejko, Jonida (2018) Perceval Sutureless Pericardial Bioprosthesis valve: Clinico-pathological
and Experimental Observations

Bioprotesi pericardiche sutureless perceval: aspetti clinico-patologici ed osservazioni sperimentali.
[Ph.D. thesis]

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Abstract (italian or english)

Excellent performances have been demonstrated in haemodynamic outcomes, safety, and versatility of use in the sutureless Perceval aortic valve (LivaNova, London, UK). However, several questions remain unanswered, especially regarding the effects of the “collapsing” during the reduction of the dimensions of the bioprostheses before implantation, and long-term durability: the design of this prosthesis closely resembles that of the Freedom Solo stentless prosthesis that was associated with a significant incidence of Structural Valve Deterioration (SVD) in different studies. Our research focused on understanding the impact of the “collapsing” in the pericardial structure and the modality of failure of this bioprosthesis when implanted in humans.

Materials and methods
To analyse the collapsing impact, 12 collapsed at 15 min (surgical procedure collapsing time), 60 and 180 min duration, and 4 uncollapsed (controls) LivaNova Perceval S prostheses were morphologically studied. Gross, histology and scanning electron microscopy (SEM) analysis were performed. Multiple sections of pericardial cusps have been stained with Hematoxylin-Eosin (HE), Azan Mallory, Elastic Van Gieson and Picrosirius Red, where a morphometrical analyses was performed by measuring the length of the collagen period.
SVD was investigated in 33 Perceval bioprosthesis explanted in different European centres, from July 2007 to January 2017, participating to PIVOT TRIAL V10601, PIVOTAL TRAIL V10801, and CAVALIER TRIAL TPS001. In all the explants gross, histology (HE, Azan Mallory, Elastic van Gieson, Von Kossa, Gram stains), were performed. To assess a potential reduction of the effective orifice area (EOA) due to fibrous tissue overgrowth, the ratio expressed in percentage between the EOA area and the total area of the bioprosthesis on ventricular side was measured.

Gross examination after collapsing and deployment revealed optimal cusp cooptation and absence of tears, perforation or folding. Moreover, prosthetic frame showed a preserved shape without distortion. Histology and SEM exhibited neither breaks nor differences in waviness periodicity of the fibrosa collagen fibers when compared to controls. Collagen wavelength periodicity measurement data did not reveal any statistically significant differences among the study groups (15 min collapse: 16.55±2.89 µm; 60 min collapse: 17.01±3.11 µm; 180 min collapse: 16.45±2.13 µm) and the un-collapsed controls (16.51±2.65 µm) and with unmounted pericardium (17.47±2.50 µm) (P=NS).
Thirtythree bioprosthesis implanted in humans were examined. Endocarditis was diagnosed in 36% of all, which was similar to that reported for bioprosthesis valves, SVD by dystrophic calcification in 12% (only 4 cases), fibrous pannus overgrowth in 12% and paravalvular leak in 12%. Fibrous tissue overgrowth (on the valve and on the stent) was 61%, with and incidence of almost 83% in the bioprostheses with time in place more than one month. This alteration involved the valve as main pathology, causing mainly orifice stenosis, or was associated to other failure modalities, as endocarditis, calcific dystrophy, or paravalvular leak. Its distribution was in the valve, in valve and nitinol stent or climbing the sole stent, occluding sometimes the spaces of nitinol network.

Pre-implantation collapse and ballooning procedures do not affect the structural integrity of the collagen fibers of the pericardial cusp tissue of Perceval S sutureless valve bioprosthesis.
In 4 cases early SVD by dystrophic calcification occurred at time in place of 5-6 years, questioning the efficacy of the anticalcification treatment of the pericardium. Progressive fibrous tissue overgrowth, invading the valve orifice, was the cause of the bioprosthesis stenosis even in absence of calcific dystrophy and did not spare the stent and nitinol network.
Despite the evolution on new technologies, design and pericardial treatment, the fibrous tissue overgrowth remains a major concern of this new generation bioprostheses.

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EPrint type:Ph.D. thesis
Tutor:Gerosa, Gino
Supervisor:Thiene, Gaetano
Ph.D. course:Ciclo 30 > Corsi 30 > SCIENZE CLINICHE E SPERIMENTALI
Data di deposito della tesi:04 September 2019
Anno di Pubblicazione:10 October 2018
Key Words:Sutureless bioprosthesis
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Area 06 - Scienze mediche > MED/23 Chirurgia cardiaca
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari
Codice ID:12030
Depositato il:08 Nov 2019 13:02
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1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet 2006; 368: 1005–11. Cerca con Google

2. Adams DH, Popma JJ, Reardon MJ, et al. Transcatheter aortic-valve replacement with a self-expanding prosthesis. N Engl J Med 2014; 370: 1790–98. Cerca con Google

3. Bonow RO, Leon MB, Doshi D, Moat N. Management strategies and future challenges for aortic valve disease. Lancet. 2016 Mar 26;387(10025):1312-23. Cerca con Google

4. Ross J Jr, Braunwald E. Aortic stenosis. Circulation 1968; 38 (suppl 1): 61–67. Cerca con Google

5. Kapadia SR1, Leon MB2, Makkar RR3, Tuzcu EM4, Svensson LG4, Kodali S2, Webb JG5, Mack MJ6, Douglas PS7, Thourani VH8, Babaliaros VC8, Herrmann HC9, Szeto WY9, Pichard AD10, Williams MR11, Fontana GP12, Miller DC13, Anderson WN14, Akin JJ, Davidson MJ15, Smith CR16; PARTNER trial investigators. 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet. 2015 Jun 20;385(9986):2485-91. Cerca con Google

6. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schäfers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M. Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC); European Association for Cardio-Thoracic Surgery (EACTS), Guidelines on the management of valvular heart disease (version 2012). Eur Heart J. 2012 Oct;33(19):2451-96. Cerca con Google

7. Rosenhek R1, Zilberszac R, Schemper M, Czerny M, Mundigler G, Graf S, Bergler-Klein J, Grimm M, Gabriel H, Maurer G. Natural history of very severe aortic stenosis. Circulation. 2010 Jan 5;121(1):151-6. Cerca con Google

8. Mohr FW, Holzhey D, Möllmann H, Beckmann A, Veit C, Figulla HR, Cremer J, Kuck KH, Lange R, Zahn R, Sack S, Schuler G, Walther T, Beyersdorf F, Böhm M, Heusch G, Funkat AK, Meinertz T, Neumann T, Papoutsis K, Schneider S, Welz A, Hamm CW; GARY Executive Board. The German Aortic Valve Registry: 1-year results from 13,680 patients with aortic valve disease. Eur J Cardiothorac Surg 2014; 46: 808–16. Cerca con Google

9. Thourani VH, Suri RM, Gunter RL, Sheng S, O'Brien SM, Ailawadi G, Szeto WY, Dewey TM, Guyton RA, Bavaria JE, Babaliaros V, Gammie JS, Svensson L, Williams M, Badhwar V, Mack MJ. Contemporary real-world outcomes of surgical aortic valve replacement in 141,905 low-risk, intermediate-risk, and high-risk patients. Ann Thorac Surg 2015; 99: 55–61. Cerca con Google

10. Pibarot P, Dumesnil JG. Prosthetic heart valves: selection of the optimal prosthesis and long-term management. Circulation 2009; 119: 1034–48. Cerca con Google

11. Cribier A, Eltchaninoff H, Bash A, Borenstein N, Tron C, Bauer F, Derumeaux G, Anselme F, Laborde F, Leon MB. Percutaneous transcatheter implantation of an aortic valve prosthesis for calcifi c aortic stenosis: first human case description. Circulation 2002; 106: 3006–08. Cerca con Google

12. Latib A, Naganuma T, Abdel-Wahab M, Danenberg H, Cota L, Barbanti M, Baumgartner H, Finkelstein A, Legrand V, de Lezo JS, Kefer J, MessikaZeitoun D, Richardt G, Stabile E, Kaleschke G, Vahanian A, Laborde JC, Leon MB, Webb JG, Panoulas VF, Maisano F, Alfieri O, Colombo A. Treatment and clinical outcomes of transcatheter heart valve thrombosis. Circ Cardiovasc Interv. 2015 Apr;8(4). Cerca con Google

13. Roy DA, Schaefer U, Guetta V, Hildick-Smith D, Möllmann H, Dumonteil N, Modine T, Bosmans J, Petronio AS, Moat N, Linke A, Moris C, Champagnac D, Parma R, Ochala A, Medvedofsky D, Patterson T, Woitek F, Jahangiri M, Laborde JC, Brecker SJ. Transcatheter aortic valve implantation for pure severe native aortic valve regurgitation. J Am Coll Cardiol. 2013 Apr 16;61(15):1577-84. Cerca con Google

14. Webb J, Htun N. Transcatheter options for the treatment of noncalcifi ed aortic regurgitation. JACC Cardiovasc Interv 2015; 8: 1850–53. Cerca con Google

15. Bourguignon T, Bouquiaux-Stablo AL, Candolfi P, Mirza A, Loardi C, May MA et al. Very long-term outcomes of the Carpentier-Edwards perimount valve in aortic position. Ann Thorac Surg 2015;99:831–37. Cerca con Google

16. Sponga S, Perron J, Dagenais F, Mohammadi S, Baillot R, Doyle D et al. Impact of residual regurgitation after aortic valve replacement. Eur J Cardiothorac Surg 2012;42:486–92. Cerca con Google

17. Robich MP, Schiltz NK, Johnston DR, Mick S, Krishnaswamy A, Iglesias RA et al. Risk factors and outcomes of patients requiring a permanent pacemaker after aortic valve replacement in the United States. J Card Surg 2016;31:476–85. Cerca con Google

18. Head SJ, Mokhles MM, Osnabrugge RL, Pibarot P, Mack MJ, Takkenberg JJ et al. The impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: a systematic review and meta-analysis of 34 observational studies comprising 27 186 patients with 133 141 patientyears. Eur Heart J 2012;33:1518–29. Cerca con Google

19. Huygens SA, Mokhles MM, Hanif M, Bekkers JA, Bogers AJ, Rutten-van Molken MP et al. Contemporary outcomes after surgical aortic valve replacement with bioprostheses and allografts: A systematic review and meta-analysis. Eur J Cardiothorac Surg 2016;50:605–16. Cerca con Google

20. Zlotnick AY, Shiran A, Lewis BS, Aravot D. Images in cardiovascular medicine. A perfectly functioning magovern-cromie sutureless prosthetic aortic valve 42 years after implantation. Circulation 2008;117:e1–2. Cerca con Google

21. Sangani NK, Suri RM. Sutureless aortic valve implantation. Oper Tech Thorac Cardiovasc Surg. http://dx.doi.org/10.1053/j.optechstcvs.2013.12. 003 (1 Mar 2015, date last accessed). Vai! Cerca con Google

22. Martens S, Sadowski J, Eckstein FS, Bartus K, Kapelak B, Sievers HH et al. Clinical experience with the ATS 3F Enable sutureless bioprosthesis. Eur J Cardiothorac Surg 2011;40:749–55. Cerca con Google

23. Shrestha M, Fischlein T, Meuris B, Flameng W, Carrel T, Madonna F et al. European multicentre experience with the sutureless perceval valve: clinical and haemodynamic outcomes up to 5 years in over 700 patients. Eur J Cardiothorac Surg 2016;49:234–41. Cerca con Google

24. Kocher AA, Laufer G, Haverich A, Shrestha M, Walther T, Misfeld M et al. One-year outcomes of the surgical treatment of aortic stenosis with a next generation surgical aortic valve (TRITON) trial: a prospective multicenter study of rapid-deployment aortic valve replacement with the EDWARDS INTUITY valve system. J Thorac Cardiovasc Surg 2013;145:110–5; discussion 115–6. Cerca con Google

25. Barnhart GR, Accola KD, Grossi EA, Woo YJ, Mumtaz MA, Sabik JF et al. TRANSFORM (Multicenter Experience With Rapid Deployment Edwards INTUITY Valve System for Aortic Valve Replacement) US clinical trial: Performance of a rapid deployment aortic valve.; TRANSFORM Trial Investigators. J Thorac Cardiovasc Surg 2017;153:241–51. Cerca con Google

26. Borger MA, Moustafine V, Conradi L, Knosalla C, Richter M, Merk DR et al. A randomized multicenter trial of minimally invasive rapid deployment versus conventional full sternotomy aortic valve replacement. Ann Thoracic Surg 2015;99:17–25. Cerca con Google

27. Englberger L, Carrel TP, Doss M, Sadowski J, Bartus K, Eckstein FF et al. Clinical performance of a sutureless aortic bioprosthesis: five-year results of the 3f enable long-term follow-up study. J Thorac Cardiovasc Surg 2014;148:1681–7. Cerca con Google

28. Otero Juan J, Rodrıguez-Caulo Emiliano A, Jose´ Mataro M, Sanchez-Esp in Gemma et al. Sutureless aortic prosthesis: review of current alternatives. Cir Cardiovasc 2016;23:312–4. Cerca con Google

29. Sadowski J, Kapelak B, Pfitzner R, Bartus K. Sutureless aortic valve bioprothesis 03F/ATS Enable0–4.5 years of a single-centre experience. Kardiol Pol 2009;67:956–63. Cerca con Google

30. Eichstaedt HC, Easo J, Harle T, Dapunt OE. Early single-center experience in sutureless aortic valve implantation in 120 patients. J Thorac Cardiovasc Surg 2014;147:370–5. Cerca con Google

31. Concistre G, Miceli A, Chiaramonti F, Glauber M. Delayed dislocation of a sutureless aortic bioprosthesis: the first case. Interact CardioVasc Thorac Surg 2012;14:892–3. Cerca con Google

32. Phan K, Tsai YC, Niranjan N, Bouchard D, Carrel TP, Dapunt OE et al. Sutureless aortic valve replacement: a systematic review and meta-analysis. Ann Cardiothorac Surg 2015;4:100–111. Cerca con Google

33. Hurley ET, O’Sullivan KE, Segurado R, Hurley JP. A meta-analysis examining differences in short-term outcomes between sutureless and conventional aortic valve prostheses. Innovations 2015;10:375–82. Cerca con Google

34. Martínez-Comendador J, Castaño M, Gualis J, Martín E, Maiorano P, Otero J. Sutureless aortic bioprosthesis. Interact Cardiovasc Thorac Surg. 2017 Jul 1;25(1):114-121. Cerca con Google

35. Pollari F, Santarpino G, Dell’Aquila AM, Gazdag L, Alnahas H, Vogt F et al. Better short-term outcome by using sutureless valves: a propensity matched score analysis. Ann Thorac Surg 2014;98:611–6; discussion 616–7. Cerca con Google

36. Takagi H, Umemoto T, Group A. Sutureless aortic valve replacement may improve early mortality compared with transcatheter aortic valve implantation: a meta-analysis of comparative studies. J Cardiol 2016;67:504–12. Cerca con Google

37. Santarpino G, Pfeiffer S, Jessl J, Dell’Aquila A, Vogt F, von Wardenburg C et al. Clinical outcome and cost analysis of sutureless versus transcatheter aortic valve implantation with propensity score matching analysis. Am J Cardiol 2015;116:1737–43. Cerca con Google

38. Ranucci M, Frigiola A, Menicanti L, Castelvecchio S, de Vincentiis C, Pistuddi V. Aortic cross-clamp time, new prostheses, and outcome in aortic valve replacement. J Heart Valve Dis 2012;21:732–9. Cerca con Google

39. Phan K, Xie A, Di Eusanio M, Yan TD. A meta-analysis of minimally invasive versus conventional sternotomy for aortic valve replacement. Ann Thorac Surg 2014;98:1499–511. Cerca con Google

40. Rosengart TK, Feldman T, Borger MA, Vassiliades TA Jr, Gillinov AM, Hoercher KJ et al. Percutaneous and minimally invasive valve procedures: A scientific statement from the american heart association council on cardiovascular surgery and anesthesia, council on clinical cardiology, functional genomics and translational biology interdisciplinary working group, and quality of care and outcomes research interdisciplinary working group. Circulation 2008;117:1750–67. Cerca con Google

41. Glauber M, Ferrarini M, Miceli A. Minimally invasive aortic valve surgery: state of the art and future directions. Ann Cardiothorac Surg 2015;4:26–32. Cerca con Google

42. Miceli A, Santarpino G, Pfeiffer S, Murzi M, Gilmanov D, Concistre G et al. Minimally invasive aortic valve replacement with perceval s sutureless valve: early outcomes and one-year survival from two european centers. J Thoracic Cardiovasc Surg 2014;148:2838–43. Cerca con Google

43. Gilmanov D, Miceli A, Ferrarini M, Farneti P, Murzi M, Solinas M et al. Aortic valve replacement through right anterior minithoracotomy: can sutureless technology improve clinical outcomes? Ann Thorac Surg 2014;98:1585–92. Cerca con Google

44. Wilbring M, Alexiou K, Schumann E, Matschke K, Tugtekin SM. Isolated aortic valve replacement in patients with small aortic annulus-a high-risk group on long-term follow-up. Thorac Cardiovasc Surg 2013;61:379–85. Cerca con Google

45. Thalji NM, Suri RM, Michelena HI, Greason KL, Dearani JA, Daly RC et al. Do differences in early haemodynamic performance of current generation biologic aortic valves predict outcomes 1 year following surgery? J Thorac Cardiovasc Surg 2015;149:163–73.e162. Cerca con Google

46. Haverich A, Wahlers TC, Borger MA, Shrestha M, Kocher AA, Walther T et al. Three-year haemodynamic performance, left ventricular mass regression, and prosthetic-patient mismatch after rapid deployment aortic valve Cerca con Google

replacement in 287 patients. J Thorac Cardiovasc Surg 2014;148:2854–60. Cerca con Google

47. Kodali SK, Williams MR, Smith CR, Svensson LG, Webb JG, Makkar RR et al. Two-year outcomes after transcatheter or surgical aortic-valve replacement. N Engl J Med 2012;366:1686–95. Cerca con Google

48. Kouchoukos, NT, Kirklin, JW. Kirklin/Barrat-Boyes Cardiac Surgery. 3rd edn. Philadelphia, PA: Churchill Livingstone, 2003. Cerca con Google

49. Stanger O, Bleuel I, Gisler F, Göber V, Reineke S, Gahl B, Aymard T, Englberger L, Carrel T, Tevaearai H. The Freedom Solo pericardial stentless valve: Single-center experience, outcomes, and long-term durability. J Thorac Cardiovasc Surg. 2015 Jul;150(1):70-7. Cerca con Google

50. Repossini A, Fischlein T, Santarpino G, Schäfer C, Claus B, Passaretti B, Di Bacco L, Giroletti L, Bisleri G, Muneretto C, Grubitzsch H. Pericardial Stentless Valve for Aortic Valve Replacement: Long-Term Results. Ann Thorac Surg. 2016 Dec;102(6):1956-1965. Cerca con Google

51. Sponga S, Della Barbera M, Pavoni D, Lechiancole A, Mazzaro E, Valente M, Nucifora G, ThieneG, Livi U. Ten-years results of the Freedom Solo stentless heart valve: excellent haemodynamics but progressive valve dysfunction in Cerca con Google

the long term. Interact Cardiovasc Thorac Surg. 2017;24(5):663-669. Cerca con Google

52. Kiefer P1, Gruenwald F, Kempfert J, Aupperle H, Seeburger J, Mohr FW, Walther T. Crimping may affect the durability of transcatheter valves: an experimental analysis. Ann Thorac Surg. 2011 Jul;92(1):155-60. Cerca con Google

53. Zegdi R1, Bruneval P, Blanchard D, Fabiani JN. Evidence of leaflet injury during percutaneous aortic valve deployment. Eur J Cardiothorac Surg. 2011 Jul;40(1):257-9. Cerca con Google

54. Della Barbera M, Valente M, Basso C, Thiene G. Pericardial traumatic injury in transcatheter aortic valve implantation. Editorial Comment. European Journal of Cardio-Thoracic Surgery 43 (2013) 493–494. Cerca con Google

55. Berkovitz BKB. Crimping of collagen in the intra-articular disc of the temporomandibular joint: a comparative study. Journal of Oral Rehabilitation, 2000. 27: 608-613. Cerca con Google

56. M.B. Leon, N. Piazza, E. Nikolsky, E.H. Blackstone, D.E. Cutlip, A.P. Kappetein, et al. Standardized endpoint definitions for Transcatheter Aortic Valve Implantation clinical trials: a consensus report from the Valve Academic Research Consortium. J Am Coll Cardiol, 57 (2011), pp. 253-269 Cerca con Google

57. Kappetein AP1, Head SJ, Généreux P, Piazza N, van Mieghem NM, Blackstone EH, Brott TG, Cohen DJ, Cutlip DE, van Es GA, Hahn RT, Kirtane AJ, Krucoff MW, Kodali S, Mack MJ, Mehran R, Rodés-Cabau J, Vranckx P, Webb JG, Cerca con Google

Windecker S, Serruys PW, Leon MB; Valve Academic Research Consortium-2. Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document. J Thorac Cardiovasc Surg. 2013 Jan;145(1):6-23. Cerca con Google

58. Pettenazzo E, Valente M, Thiene G. Octanediol treatment of glutaraldehyde fixed bovine pericardium: evidence of anticalcification efficacy in the subcutaneous rat model. Eur J. Cardiothorac. Surg. 200. 32: 418-422. Cerca con Google

59. Wollersheim LW, Li WW, Bouma BJ, Repossini A, van der Meulen J, de Mol BA. Aortic Valve Replacement With the Stentless Freedom SOLO Bioprosthesis: A Systematic Review. Ann Thorac Surg. 2015;100(4):1496-504. Cerca con Google

60. Christ T, Claus B, Zielinski C, Falk V, Grubitzsch H. Long-Term Outcome of the Sorin Freedom SOLO Stentless Aortic Valve. J Heart Valve Dis. 2016 Nov;25(6):679-684. Cerca con Google

61. Bouhout I, Noly PE, Parisi A, et al. First case of perceval S prosthesis early structural valve deterioration: not an easy reoperation. J Thorac Cardiovasc Surg. 2016;152:e71–e73. Cerca con Google

62. Vötsch A, Weihs W, Asslaber M, et al. Perceval sutureless valve dysfunction caused by valvular thrombosis. Ann Thorac Surg. 2016;102: e309–e311. Cerca con Google

63. Santarpino G, Pfeiffer S, Concistrè G, Fischlein T. Perceval sutureless aortic valve prosthesis: easy, fast, and safe. Innovations. 2011;6:378–381. Cerca con Google

64. Zannis K, Joffre J, Czitrom D, et al. Aortic valve replacement with the perceval S bioprosthesis: single-center experience in 143 patients. J Heart Valve Dis. 2014;23:795–802. Cerca con Google

65. Folliguet TA, Laborde F, Zannis K, et al. Sutureless perceval aortic valve replacement: results of two european centers. Ann Thorac Surg. 2012;93:1483–1488. Cerca con Google

66. Fleissner F1, Molitoris U2, Shrestha M3, Martens A3. Stent distortion after sutureless aortic valve implantation: a new complication seen with a novel surgical technique. Interact Cardiovasc Thorac Surg. 2015 Mar;20(3):436-8. Cerca con Google

67. Tao E, Wan L, Wang W, Luo Y, Zeng J, Wu X. The prognosis of infective endocarditis treated with biological valves versus mechanical valves: A metaanalysis. PLoS One. 2017 Apr 13;12(4):e0174519. Cerca con Google

68. McClure RS, Narayanasamy N, Wiegerinck E, Lipsitz S, Maloney A, Byrne JG, et al. Late outcomes for aortic valve replacement with Carpentier-Edwards peri- cardial bioprosthesis: up to 17-year follow-up in 1000 patients. Ann Cerca con Google

Thorac Surg. 2010; 89:1410-6. Cerca con Google

69. Allavi SH, Groves EM, Keradvar A. The effects of transcatheter valve crimping on pericardial leaflets. Ann Thorac Surg, 2014; 97: 1260-6. Cerca con Google

70. Nietlispach F, Webb JG, Ye J, et al. Pathology of transcatheter valve therapy. JACC Cardiovasc Interv 2012;5:582–90. Cerca con Google

71. Weber B, Robert J, Ksiazek A, Wyss Y, Frese L, Slamecka J, Kehl D, Modregger P, Peter S, Stampanoni M, Proulx S, Falk V, Hoerstrup SP. Living-engineered valves for transcatheter venous valve repair. Tissue Eng Part C Methods. 2014;20(6):451-63. Cerca con Google

72. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Muñoz D, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL; ESC Scientific Document Group. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017 Sep 21;38(36):2739-2791 Cerca con Google

73. Foroutan F, Guyatt GH, Otto CM, Siemieniuk RA, Schandelmaier S, Agoritsas T, Vandvik PO, Bhagra S, Bagur R. Structural valve deterioration after transcatheter aortic valve implantation. Heart. 2017;103(23):1899-1905. Cerca con Google

74. Fleerakkers J, Schepens M, Ranschaert W, Verrelst P, Graulus E. Aortic valve replacement using the Freedom SOLO stentless bioprosthesis: clinical and haemodynamic performance in 625 patients at medium-term follow-up. Eur J Cardiothoac Surg. 2018 May 24. Epub ahead of print Cerca con Google

75. Toker ME, Eren E, Balkanay M, Kirali K, Yanartas M, Caliskan A, Guler M, Yakut C. Multivariate analysis for operative mortality in obstructive prosthetic valve dysfunction due to pannus and thrombus formation. Int Heart J. 2006;47:237–245. Cerca con Google

76. Teshima H, Fukunaga S, Takaseya T, Tomoeda H, Akashi H, Aoyagi S. Obstruction of St. Medical Valves in the Aortic Position: Plasma Transforming Growth Factor Type Beta 1 in patients With Pannus Overgrowth. J Artif Organs. 2010;34(3):210–215. Cerca con Google

77. Teshima H, Hayashida N, Yano H, Nishimi M, Tayama E, Fukunaga S, Akashi H, Kawara T, Aoyagi S. Obstruction of St. Jude Medical valves in the aortic position:histology and immunohistochemistry of pannus. J Thorac Cardiovasc Surg. 2003;126(2):401–407. Cerca con Google

78. Mullenix PS, Parsa CJ, Mackensen GB, Jollis JG, Harrison JK, Hughes GC. Pannus - related prosthetic valve dysfunction and life-threatening aortic regurgitation. J Heart Valve Dis.2008;17(6):666–669. Cerca con Google

79. Kuniyoshi Y, Kojak M, Shimoji M, Uezu T, Arakaki K, Yamashiro S, Mabuni K, Senaha S, Nakasone Y. Pannus formation in aortic valve prosthesis in the late postoperative period. J Artif Organs. 2003;6(3):179–182. Cerca con Google

80. Cianciulli TF, Saccheri MC, Lax JA, Guidoin R, Zhang Z, Guerra JE, Prezioso HA, Vidal LA. Intermittent acute aortic regurgitation of a mechanical bileaflet aortic valve prosthesis: diagnosis and clinical implications. Eur J Echocardiogr. 2009;10(3):446–449. Cerca con Google

81. Weber B, Robert J, Ksiazek A, Wyss Y, Frese L, Slamecka J, Kehl D, Modregger P, Peter S, Stampanoni M, Proulx S, Falk V, Hoerstrup SP. Tissue Eng Part C Methods. 2014 Jun;20(6):451-63. doi: 10.1089/ten.TEC.2013.0187. Epub 2014 Jan 20. Living-engineered valves for transcatheter venous valve repair. Cerca con Google

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