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Mocellin, Simone - Provenzano, Maurizio (2004) RNA interference: learning gene knock-down from cell physiology. [Articolo di periodico (online)]

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Abstract (inglese)

Over the past decade RNA interference (RNAi) has emerged as a natural mechanism for silencing gene expression. This ancient cellular antiviral response can be exploited to allow specific inhibition of the function of any chosen target gene. RNAi is proving to be an invaluable research tool, allowing much more rapid characterization of the function of known genes. More importantly, RNAi technology considerably bolsters functional genomics to aid in the identification of novel genes involved in disease processes.

This review briefly describes the molecular principles underlying the biology of RNAi phenomenon and discuss the main technical issues regarding optimization of RNAi experimental design.


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Tipo di EPrint:Articolo di periodico (online)
Anno di Pubblicazione:2004
Parole chiave (italiano / inglese):genomics, RNA, gene
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/03 Genetica medica
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze Oncologiche e Chirurgiche
Codice ID:1237
Depositato il:09 Dic 2008
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