Provenzano, Maurizio - Bracci, Laura - Wyler, Stephen - Hudolin, Tvrtko - Sais, Giovanni - Gosert, Rainer - Zajac, Paul - Palu, Giorgio - Heberer, Michael - Hirsch, Hans H - Spagnoli, Giulio C (2006) Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors. [Articolo di periodico (online)]
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Human polyomavirus BK (BKV) has been implicated in oncogenic transformation. Its ability to replicate is determined by the binding of its large tumor antigen (LTag) to products of tumor-suppressor genes regulating cell cycle, as specifically p53. We investigated CD8+ T immune responses to BKV LTag portions involved in p53 binding in HLA-A*0201+ BKV LTag experienced individuals.
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