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Grizzi, Fabio - Di Ieva, Antonio - Russo , Carlo - Frezza, Eldo E - Cobos, Everardo - Muzzio, Pier Carlo - Chiriva-Internati, Maurizio (2006) Cancer initiation and progression: an unsimplifiable complexity. [Articolo di periodico (online)]

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Abstract (inglese)

Background

Cancer remains one of the most complex diseases affecting humans and, despite the impressive advances that have been made in molecular and cell biology, how cancer cells progress through carcinogenesis and acquire their metastatic ability is still widely debated.

Conclusion

There is no doubt that human carcinogenesis is a dynamic process that depends on a large number of variables and is regulated at multiple spatial and temporal scales. Viewing cancer as a system that is dynamically complex in time and space will, however, probably reveal more about its underlying behavioural characteristics. It is encouraging that mathematicians, biologists and clinicians continue to contribute together towards a common quantitative understanding of cancer complexity. This way of thinking may further help to clarify concepts, interpret new and old experimental data, indicate alternative experiments and categorize the acquired knowledge on the basis of the similarities and/or shared behaviours of very different tumours.


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Tipo di EPrint:Articolo di periodico (online)
Anno di Pubblicazione:2006
Parole chiave (italiano / inglese):carcinogenesis, metastatic
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/06 Oncologia medica
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze Medico Diagnostiche e Terapie Speciali
Codice ID:1256
Depositato il:09 Dic 2008
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