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Grizzi, Fabio and Di Ieva, Antonio and Russo , Carlo and Frezza, Eldo E and Cobos, Everardo and Muzzio, Pier Carlo and Chiriva-Internati, Maurizio (2006) Cancer initiation and progression: an unsimplifiable complexity. [Online journal papers]

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Abstract (english)

Background

Cancer remains one of the most complex diseases affecting humans and, despite the impressive advances that have been made in molecular and cell biology, how cancer cells progress through carcinogenesis and acquire their metastatic ability is still widely debated.

Conclusion

There is no doubt that human carcinogenesis is a dynamic process that depends on a large number of variables and is regulated at multiple spatial and temporal scales. Viewing cancer as a system that is dynamically complex in time and space will, however, probably reveal more about its underlying behavioural characteristics. It is encouraging that mathematicians, biologists and clinicians continue to contribute together towards a common quantitative understanding of cancer complexity. This way of thinking may further help to clarify concepts, interpret new and old experimental data, indicate alternative experiments and categorize the acquired knowledge on the basis of the similarities and/or shared behaviours of very different tumours.


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EPrint type:Online journal papers
Anno di Pubblicazione:2006
Key Words:carcinogenesis, metastatic
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/06 Oncologia medica
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Scienze Medico Diagnostiche e Terapie Speciali
Codice ID:1256
Depositato il:09 Dec 2008
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