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Agostini , Carlo and Calabrese, Fiorella and Poletti, Venerino and Marcer, Guido and Facco, Monica and Miorin, Marta and Cabrelle, Anna and Baesso, Ilenia and Zambello, Renato and Trentin, Livio and Semenzato, Gianpietro (2005) CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis. [Online journal papers]

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Abstract (english)

Background

Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by repeated inhalations of finely dispersed organic particles or low molecular weight chemicals. The disease is characterized by an alveolitis sustained by CD8(+) cytotoxic T lymphocytes, granuloma formation, and, whenever antigenic exposition continues, fibrosis. Although it is known that T-cell migration into the lungs is crucial in HP reaction, mechanisms implicated in this process remain undefined.

Methods

Using flow cytometry, immunohistochemistry, confocal microscopy analysis and chemotaxis assays we evaluated whether CXCL10 and its receptor CXCR3 regulate the trafficking of CD8(+) T cells in HP lung.

Results

Our data demonstrated that lymphocytes infiltrating lung biopsies are CD8 T cells which strongly stain for CXCR3. However, T cells accumulating in the BAL of HP were CXCR3(+)/IFN?(+) Tc1 cells exhibiting a strong in vitro migratory capability in response to CXCL10. Alveolar macrophages expressed and secreted, in response to IFN-?, definite levels of CXCL10 capable of inducing chemotaxis of the CXCR3(+) T-cell line. Interestingly, striking levels of CXCR3 ligands could be demonstrated in the fluid component of the BAL in individuals with HP.

Conclusion

These data indicate that IFN-? mediates the recruitment of lymphocytes into the lung via production of the chemokine CXCL10, resulting in Tc1-cell alveolitis and granuloma formation.


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EPrint type:Online journal papers
Anno di Pubblicazione:2005
Key Words:Hypersensitivity pneumonitis, alveolitis sustained.
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/10 Malattie dell'apparato respiratorio
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Medicina Clinica e Sperimentale
Dipartimenti > pre 2012 Dipartimento di Medicina Ambientale e Sanità pubblica
Dipartimenti > pre 2012 - Dipartimento di Scienze Medico Diagnostiche e Terapie Speciali
Codice ID:1265
Depositato il:09 Dec 2008
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