Go to the content. | Move to the navigation | Go to the site search | Go to the menu | Contacts | Accessibility

| Create Account

Vecchione, Andrea and Prayer Galetti, Tommaso and Gardiman, Marina and Ishii, Hideshi and Giarnieri, Enrico and Pagano, Francesco and Gomella, Leonard G and Croce, Carlo M and Baffa, Raffaele (2004) Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases. [Online journal papers]

Full text disponibile come:

[img]
Preview
Documento PDF
958Kb

Per gentile concessione di: http://www.biomedcentral.com/1471-2490/4/11

Abstract (english)

Background

Collecting duct carcinoma (CDC) is a rare but very aggressive variant of kidney carcinoma that arises from the epithelium of Bellini's ducts, in the distal portion of the nephron. In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2).

Methods

We studied eleven patients who underwent radical nephrectomy for primary CDC. All patients had an adequate clinical follow-up and none of them received any systemic therapy before surgery. The expression of the five markers for tumor initiation and/or progression were assessed by immunohistochemistry and correlated to the clinicopathological parameters, and survival by univariate analysis.

Results

Results showed that Fez1 protein expression was undetectable or substantially reduced in 7 of the 11 (64%) cases. Fhit protein was absent in three cases (27%). The overexpression of p53 protein was predominantly nuclear and detected in 4 of 11 cases (36%). Immunostaining for p27 was absent in 5 of 11 cases (45.5%). Five of the six remaining cases (90%) showed exclusively cytoplasmic protein expression, where, in the last case, p27 protein was detected in both nucleus and cytoplasm. Bcl2 expression with 100% of the tumor cells positive was observed in 4 of 11 (36%) cases. Statistical analysis showed a statistical trend (P = 0.06) between loss and reduction of Fez1 and presence of lymph node metastases.

Conclusions

These findings suggest that Fez1 may represent not only a molecular diagnostic marker but also a prognostic marker in CDC.


Statistiche Download - Aggiungi a RefWorks
EPrint type:Online journal papers
Anno di Pubblicazione:2004
Key Words:carcinoma, renal cancer
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/06 Oncologia medica
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Scienze Oncologiche e Chirurgiche
Codice ID:1270
Depositato il:09 Dec 2008
Simple Metadata
Full Metadata
EndNote Format

Download statistics

Solo per lo Staff dell Archivio: Modifica questo record