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Giannotti, Elena (2009) Clinical and molecular approaches to investigate drug-induced testicular toxicity. [Tesi di dottorato]

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Abstract (inglese)

The aims of this study are:
setting up investigative protocols to monitor hypothalamus-pituitary-gonads hormone profile in rats;
development of inhibin B biomarker in rats;
in vitro models to assess drug-induced alterations on blood testis barrier.

Abstract (italiano)

Gli obiettivi di questo lavoro si sono articolati principalmente su tre linee di ricerca:
messa a punto di modelli sperimentali su roditore per il monitoraggio di variazioni ormonali indotte da farmaci;
sviluppo di un marcatore bioumorale di tossicità delle cellule del Sertoli: InibinaB;
sviluppo di un test di screening in vitro per composti che alterino la permeabilità della barriera emato-testicolare.

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Tipo di EPrint:Tesi di dottorato
Relatore:Mantero, Franco
Correlatore:Mariniello, Barbara
Dottorato (corsi e scuole):Ciclo 20 > Scuole per il 20simo ciclo > SCIENZE MEDICHE, CLINICHE E SPERIMENTALI > METODOLOGIA CLINICA ED ENDOCRINOLOGIA
Data di deposito della tesi:27 Gennaio 2009
Anno di Pubblicazione:2009
Parole chiave (italiano / inglese):Testosterone, FSH, Inibina B, Barriera ematotesticolare, giunzioni occludenti
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/13 Endocrinologia
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Scienze Mediche e Chirurgiche
Codice ID:1435
Depositato il:27 Gen 2009
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