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Redaelli, Marco (2009) Herpes virus bovino di tipo 4 come vettore per la terapia genica dei gliomi. [Tesi di dottorato]

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Abstract (inglese)

Gliomas are considered among the most puzzling problems of medicine due to the complexity of their anatomic localization, and the lack of a real therapeutic treatment. The main topic of this work concerns the possibility to use bovine herpesvirus type 4 (BoHV-4) as a vector for gene therapy for the treatment of glioma, and that the cAMP-dependent protein kinases (PKA) pathway as a possible target for such therapy.
This study is based on a research project that involved both University of Padova and University of Parma.
Here BoHV-4 to is shown to infect rat glioma cells in vitro and in vivo, in addition, BoHV-4 can infect human immortalized glioma cells in vitro and human brain tumour primary cell cultures.
The study of the relationship between gliomas and the PKA pathway shows a peculiar distribution of the PKA regulatory subunits in glioma cells in mouse, rat and human. The present data suggest that the PKA pathway modulation may be targeted for the treatment of gliomas.
The present Study pave the way to the use of a safe and efficient BoHV-4-based vector for the delivery of therapeutic genes or for the targeting of specific abnormal pathways, like the PKA-mediated one, for the treatment of the hopeless high-grade glioma.

Abstract (italiano)

L’ipotesi alla base di questo lavoro è che vi sia la possibilità di impiegare quale vettore virale per la terapia genica dei gliomi l’herpesvirus bovino di tipo 4 (BoHV-4) e di determinare se la via di trasduzione del segnale mediata dalle protein chinasi AMPc-dipendenti (PKA) possa essere utilizzata come bersaglio terapeutico. Infatti i gliomi sono ritenuti essere uno dei più importanti e stimolanti problemi irrisolti della medicina. Questo sia per la evidente complessità della sede anatomica di insorgenza, sia per il fatto che, nonostante gli enormi sforzi in cui gli scienziati di tutto il mondo si sono profusi non si è ancora riusciti a giungere alla messa a punto di un protocollo curativo realmente efficace.
Il progetto di ricerca su cui si è basato il presente studio è il risultato della convergenza di due linee di ricerca preesistenti presso le Università di Padova e di Parma.
I risultati conseguiti hanno dimostrato la capacità di BoHV-4 di infettare in vitro e in vivo cellule di glioma di ratto. Inoltre tale capacità è stata confermata in vitro sia su cellule immortalizzate di glioma umano che su colture primarie di tumore cerebrale umano.
Per quanto riguarda lo studio della relazione tra PKA e tumori cerebrali, è stato in primo luogo rilevata una distribuzione peculiare delle diverse subunità regolatorie delle medesime che è caratteristica delle cellule di glioma. Inoltre diversi esperimenti suggeriscono che la modulazione di tale via possa essere impiegata per il trattamento dei gliomi oltre che per fini diagnostici.
Tutti i risultati ottenuti suggeriscono di proseguire ed ampliare il progetto facendo convergere entrambe le sue linee costituenti in un modello da poter esportare nella pratica clinica nel minor tempo possibile.

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Tipo di EPrint:Tesi di dottorato
Relatore:Mucignat, Carla
Dottorato (corsi e scuole):Ciclo 21 > Scuole per il 21simo ciclo > SCIENZE MEDICHE, CLINICHE E SPERIMENTALI > NEUROSCIENZE
Data di deposito della tesi:28 Gennaio 2009
Anno di Pubblicazione:Gennaio 2009
Parole chiave (italiano / inglese):Glioma, BoHV-4, vettori virali, PKA, terapia genica
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/06 Oncologia medica
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Anatomia e Fisiologia Umana
Codice ID:1535
Depositato il:28 Gen 2009
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Le url contenute in alcuni riferimenti sono raggiungibili cliccando sul link alla fine della citazione (Vai!) e tramite Google (Ricerca con Google). Il risultato dipende dalla formattazione della citazione.

Akard W, Tubbs RS, Seymour ZA, Hitselberger WE, Cohen-Gadol AA. 2008. Evolution of techniques for the resection of vestibular schwannomas: from saving life to saving function. J Neurosurg. ahead of print. Cerca con Google

Ackermann M. 2006. Pathogenesis of gammaherpesvirus infections. Vet Microbiol. 113(3-4):211-22. Cerca con Google

Alemany R, Balagué C, Curiel DT. 2000. Replicative adenoviruses for cancer therapy. Nat Biotechnol. 18(7):723-7. Cerca con Google

Almqvist PM, Mah R, Lendahl U, Jacobsson B, Hendson G. 2002. Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem Cytochem. 50(2):147-58. Cerca con Google

Anella NS, Ding Q, Menegazzo I, Wang W, Gillespie GY, Grammer JR, Gladson CL, Nabors LB. 2005. A novel technique to quantify glioma tumor invasion using serial microscopy sections. Journal of Neuroscience Methods 153, 183-189. Cerca con Google

Axelsson U, Laurell CB. 1965. Hereditary variants of serum alpha-1-antitrypsin. Am J Hum Genet. 1965 Nov;17(6):466-72. Cerca con Google

Balfour HH Jr. 1999. Antiviral drugs. N Engl J Med. 340(16):1255-68. Cerca con Google

Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. 2006. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 444(7120):756-60. Cerca con Google

Berger MS, Hadjipanayis CG. 2007. Surgery of intrinsic cerebral tumors. Neurosurgery. 61(1 Suppl):279-304; discussion 304-5. Cerca con Google

Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor SS. 2005. The AMPc binding domain: an ancient signaling module. Proc Natl Acad Sci U S A. 102(1):45-50. Cerca con Google

Blaese RM, Culver KW, Chang L, Anderson WF, Mullen C, Nienhuis A, Carter C, Dunbar C, Leitman S, Berger M, et al. 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with CD34+ selected autologous peripheral blood cells transduced with a human ADA gene. Hum Gene Ther. 1993 Aug;4(4):521-7. Cerca con Google

Bleiziffer O, Eriksson E, Yao F, Horch RE, Kneser U. 2007. Gene transfer strategies in tissue engineering. J Cell Mol Med. 11(2):206-23. Cerca con Google

Bloom DC. 2004. HSV LAT and neuronal survival. Int Rev Immunol. 23(1-2):187-98. Cerca con Google

Bossis I, Stratakis CA. 2004. Minireview: PRKAR1A: normal and abnormal functions. Endocrinology 145:5452-8. Cerca con Google

Brown MT, Goetsch L, Hartwell LH. 1993. MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. J Cell Biol. 123(2):387-403. Cerca con Google

Cadd G, McKnight GS. 1989. Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain. Neuron. 3(1):71-9. Cerca con Google

Charalampaki P, Filippi R, Welschehold S, Conrad J, Perneczky A. 2008. Tumors of the lateral and third ventricle: removal under endoscope-assisted keyhole conditions. Neurosurgery. 62(6 Suppl 3):1049-58. Cerca con Google

Chen TC, Hinton DR, Zidovetzki R, Hofman FM. 1998. Up-regulation of the AMPc/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant glioma. Lab Invest.;78:165-74. Cerca con Google

Chicoine MR, Rich KM. 2008. Clinical management of frequently encountered brain tumors. Mo Med. 105(5):429-33. Cerca con Google

Chiocca EA. 2002. Oncolitytic viruses. Nat. Rev. Cancer 2:938-950. Cerca con Google

Cho-Chung YS, Nesterova MV. 2005. Tumor reversion: protein kinase A isozyme switching. Ann. N.Y. Acad. Sci. 1058: 76-86. Cerca con Google

Cho-Chung YS. 1990. Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignacy: new approces to therapy. cancer res. 50:7093-7100. Cerca con Google

Clegg CH, Cadd GG, McKnight GS. 1988. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 85(11):3703-7. Cerca con Google

Curtin BF, Pal N, Gordon RK, Nambiar MP.2006. Forskolin, an inducer of AMPc, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells. Mol Cell Biochem. 290(1-2):23-32. Cerca con Google

Danthinne X, Imperiale MJ. 2000. Production of first generation adenovirus vectors: a review. Gene Ther. 7(20):1707-14. Cerca con Google

Dario A, Tomei G. 2006. The safety of the temozolomide in patients with malignant glioma.Curr Drug Saf. 1(2):205-22. Cerca con Google

Davies SP, Reddy H, Caivano M, Cohen P. 2000. Specificity and mechanism of action of some commonly protein kinase inhibitors. Biochem J.; 351:95-105. Cerca con Google

Dent P, Yacoub A, Park M, Sarkar D, Shah K, Curiel DT, Grant S, Fischer PB. 2008. Searching for a cure: gene therapy for glioblastoma. Cancer Biol Ther. 7(9):1335-40. Cerca con Google

DePace N. 1912. Sulla scomparsa di un enormo cancro vegetante del collo dell'utero senza cura chirurgica. Ginecologia 9:82-89. Cerca con Google

Dock G. 1904. Rabies virus vaccination in a patient with cervical carcinoma. Am. J. Med. Sci. 127:563 Cerca con Google

Donelson Smith F, Langeberg LK, Scott JD. 2006. The where’s and when’s of kinase anchoring. Trends Biochem Sci. 31:316-323. Cerca con Google

Donofrio G, Cavirani S, Simone T, van Santen VL. 2002. Potential of bovine herpesvirus 4 as a gene delivery vector. J. Virol. Methods 10 , 49–61. Cerca con Google

Donofrio G, Grandi G, Cavirani S, Taddei S, Flammini C. 2004. Bovine herpesvirus 4 infects differentiated neuronal cells in culture and establish persistent infection upon selection. J Neurovirol. 10(2):123-30. Cerca con Google

Donofrio G, Cavaggioni A, Bondi M, Cavirani S, Flammini CF, Mucignat-Caretta C. 2006. Outcome of bovine herpesvirus 4 infection following direct viral injection in the lateral ventricle of the mouse brain. Microbes Infect. 8, 898-904. Cerca con Google

Donofrio G, Herath S, Sartori C, Cavirani S, Flammini CF, Sheldon IM. 2007. Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function. Reproduction. 134(1):183-97. Cerca con Google

Donofrio G, Martignani E, Cavirani S, Flammini CF. 2005. Exploiting persistent infection for selection of bovine herpesvirus 4 recombinants. J Virol Methods. 128(1-2):6-13. Cerca con Google

Døskeland SO, Maronde E, Gjertsen BT. 1993. The genetic subtypes of cAMP-dependent protein kinase--functionally different or redundant? Biochim Biophys Acta. 1178(3):249-58. Cerca con Google

Egyed L, Bartha A. 1998. PCR studies on the potential sites for latency of BoHV-4 in calves. Vet. Res. Commun, 22 , 209–216. Cerca con Google

Egyed L. 1998. Replication of Bovine herpesvirus type 4 in human cells in vitro. J. Clin. Microbiol 36:2109-2111 Cerca con Google

Egyed L, Kluge JP, Bartha A. 1997. Histological studies of bovine herpesvirus type 4 infection in non ruminant species. Veterinary Microbiology 51, 283-288. Cerca con Google

Ferrari S. 2006. Protein kinases controlling the onset of mitosis, Cell Mol Life Sci 63:781-95. Cerca con Google

Francio SH, Corbin JD. 1994. Structure and functionof cyclic nucleotide dependent protein kinase. Annu. Rev. Physiol. 56, 237-272. Cerca con Google

Franklin BJ, Paxinos G. 1997. The Mouse Brain, in stereotaxic coordinates. Academic Press. San Diego, USA. Cerca con Google

Frattola L, Canal N, Ferrarese C, et al. 1983. Multiple forms of protein kinase from normal human brain and glioblastoma. Cancer Res. 43:1321-1324. Cerca con Google

Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, Fiocco R, Foroni C, Dimeco F, Vescovi A. 2004. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 2004 Oct 1;64(19):7011-21. Cerca con Google

Garret RH, Grisham CM. 2004. Principi di biochimica. Con messa a fuoco su quella umana. Ed. Piccin Cerca con Google

Gaskell R, Willoughby K. 1999. Herpesviruses of carnivores. Vet Microbiol. 69(1-2):73-88. Cerca con Google

Gillet L, Minner F, Detry B. 2004. Investigation of the susceptibility of human cell lines to bovine herpesvirus 4 infection: demonstration that human cells can support a nonpermissive persistent infection wich protects them against tumor necrosis factor a-induced apoptosis. J. Virol. 78:2336-2347. Cerca con Google

Gillet L, Dewals M, Farnir F, de Leval L, Vanderplasschen A. 2005 Bovine herpesvirus 4 induces apoptosis of Human Carcinoma cell lines in vitro andin vivo. Cancer Res. 65:(20). Cerca con Google

Gjertsen BT, Døskeland SO. 1995. Protein phosphorylation in apoptosis. Biochim Biophys Acta. 1269(2):187-99. Cerca con Google

Gonzàles-Agùero G, Ondarza R, Gamboa-Domìnguez R, Cerbòn MA, Camacho-Arroyo I. 2001. Progesterone receptor isoform expression pattern in human astrocytomas. Brain Res. Bull.; 56: 43-48. Cerca con Google

Graça J, Gültasli N, D'Haene N, Brotchi J, Salmon I, Balériaux D. 2006. Cystic extramedullary ependymoma. JNR Am J Neuroradiol. 27(4):818-21. Cerca con Google

Hanks SK, Hunter T. 1995. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9(8):576-96. Cerca con Google

Harrow S, Papanastassiou V, Harland J, Mabbs R, Petty R, Fraser M, Hadley D, Patterson J, Brown SM, Rampling R. 2004. HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival. Gene Ther. 11(22):16 Cerca con Google

Hart MG, Grant R, Garside R, Rogers G, Somerville M, Stein K. 2008. Temozolomide for high grade glioma. Cochrane Database Syst Rev. (4):CD007415. Cerca con Google

Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R. 2005. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 352(10):997-1003. Cerca con Google

Herold-Mende C, Mueller MM, Bonsanto MM, Schmitt HP, Kunze S, Steiner HH. 2002. Clinical impact and functional aspects of tenascin-C expression during glioma progression. Int J Cancer. 2002 Mar 20;98(3):362-9. Cerca con Google

Horan PK, Melnicoff MJ, Jensen BD, Slezak SE. 1990. Fluorescent cell labeling for in vivo and in vitro cell tracking. Methods Cell Biol. 1990;33:469-90. Cerca con Google

Horan PK, Slezak SE. 1989. Stable cell membrane labelling. Nature. 13;340(6229):167-8. Cerca con Google

Hubbard MJ, Cohen P. 1993. On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem Sci. 18(5):172-7. Cerca con Google

Huggenvik JI, Collard MW, Stofko RE, Seasholtz AF, Uhler MD. 1991. Regulation of the human enkephalin promoter by two isoforms of the catalytic subunit of cyclic adenosine 3',5'-monophosphate-dependent protein kinase. Mol Endocrinol. 5(7):921-30. Cerca con Google

Hulleman E, Helin K. 2005. Molecular mechanisms in gliomagenesis. Adv Cancer Res. 94:1-27. Cerca con Google

Hutterer M, Gunsilius E, Stockhammer G. 2006. Molecular therapies for malignant glioma. Wien Med Wochenschr. 2006 Jun;156(11-12):351-63. Cerca con Google

Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. 2002. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia. 2002 Sep;39(3):193-206. Cerca con Google

Immonen A, Vapalahti M, Tyynelä K, Hurskainen H, Sandmair A, Vanninen R, Langford G, Murray N, Ylä-Herttuala S. 2004. AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study. Mol Ther. 10(5):967-72. Cerca con Google

Inoue N, Dambaugh TR, Pellett PE. 1993. Molecular biology of human herpesviruses 6A and 6B. Infect Agents Dis. 2(6):343-60. Cerca con Google

Jackson CA, Cobbs C, Peduzzi JD, Novak M, Morrow CD. 2001. Repetitive intrathecal injections of poliovirus replicons result in gene expression in neurons of the central nervous system without pathogenesis. Hum Gene Ther. 12(15):1827-41. Cerca con Google

Kanerva A, Hemminki A. 2004. Modified adenoviruses for cancer gene therapy. Int J Cancer. 110(4):475-80. Cerca con Google

Kassam AB, Engh JA, Mintz AH, Prevedello DM. 2008. Completely endoscopic resection of intraparenchymal brain tumors. J Neurosurg. ahead of print. Cerca con Google

Kaufmann WK, Heffernan TP, Beaulieu LM, Doherty S, Frank AR, Zhou Y, Bryant MF, Zhou T, Nikolaishvili-Feinberg DDN, Simpson DA, Cordeiro-Stone M. 2003. Caffeine and human DNA metabolism: the magic and the mystery. Mutat Res.; 532: 85-102. Cerca con Google

Kay MA, Glorioso JC, Naldini L. 2001. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med. 7(1):33-40. Cerca con Google

Kirn D, Martuza RL, Zwiebel J. 2001. Replication-selective virotherapy for cancer: Biological principles, risk management and future directions. Nat Med. 7(7):781-7. Cerca con Google

Kleihues P. 2000. Glioblastoma. In Kleihues P, Cavanee WK, eds., Pathology and genetics of tumors of nervous system, World Health Organization classification of tumours. Lyon France: IARC. Cerca con Google

Ko L, Koestner A, Wechsler W. 1980. Morphological characterization of nitrosourea-induced glioma cell lines and clones. Acta Neuropathol. 51(1):23-31. Cerca con Google

Kun LE, Gajjar A, Muhlbauer M, Heideman RL, Sanford R, Brenner M, Walter A, Langston J, Jenkins J, Facchini S. 1995. Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors. Hum Gene Ther. 1995 Sep;6(9):1231-55. Cerca con Google

Landolfo S, Gariglio M, Gribaudo G, Lembo D. 2003. The human cytomegalovirus. Pharmacol Ther. 98(3):269-97. Cerca con Google

Lantos PL, VandenBerg SR, Kleihues P. 1996. Tumor of the Nervous System. In: Greenfield’s Neuropathology, Graham DI, Lantod PL (eds), 6th ed. Arnold: London. Pag. 583-879. Cerca con Google

Larjavaara S, Mäntylä R, Salminen T, Haapasalo H, Raitanen J, Jääskeläinen J, Auvinen A. 2007. Incidence of gliomas by anatomic location. Neuro Oncol. 9(3):319-25. Cerca con Google

Lawler SE, Peruzzi PP, Chiocca EA. 2006. Genetic strategies for brain tumor therapy. Cancer Gene Ther. 13(3):225-33. Cerca con Google

Lee HO, Koh EJ, Oh YM, Choi HY. 2008. Midline glioblastoma multiforme with bilateral symmetric cysts. J Korean Neurosurg Soc.43(2):105-8. Cerca con Google

Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin D, Black KL, Yu JS. 2006 Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer. 5:67. Cerca con Google

Ljubimova JY, Fugita M, Khazenzon NM, Das A, Pikul BB, Newman D, Sekiguchi K, Sorokin LM, Sasaki T, Black KL. 2004. Association between laminin-8 and glial tumor grade, recurrence, and patient survival. Cancer. 2004 Aug 1;101(3):604-12. Cerca con Google

Lochner A, Moolman JA. 2006. The many faces of H89: a review. Cardiovasc Drug Rev. 24(3-4):261-74. Cerca con Google

Makino Y, Sakagami H, Takeda M. 1999. Induction of cell death by ascorbic acid derivatives in human renal carcinoma and glioblastoma cell lines. Anticancer Res. 19(4B):3125-32. Cerca con Google

Markert JM, Medlock MD, Rabkin SD, Gillespie GY, Todo T, Hunter WD, Palmer CA, Feigenbaum F, Tornatore C, Tufaro F, Martuza RL. 2000. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Ther. 7(10):867-74. Cerca con Google

Mathupala SP, Guthikonda M, Sloan AE. 2006. RNAi based approaches to the treatment of malignant glioma. Technol Cancer Res Treat. 5(3):261-9. Cerca con Google

Matten W, Daar I, Vande Woude GF. 1994. Protein kinase A acts at multiple points to inhibit Xenopus oocyte maturation. Mol Cell Biol. 14(7):4419-26. Cerca con Google

Maus U, Herold S, Muth H, Maus R, Ermert L, Ermert M, Weissmann N, Rosseau S, Seeger W, Grimminger F, Lohmeyer J. 2001. Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14. Am J Physiol Lung Cell Mol Physiol. 280(1):L58-68. Cerca con Google

McDaid HM, Cairns MT, Atkinson RI. 1999. Incereased expression of the RIa subunit of the cAMP-dependent protein kinase A is associated with associated stage of the ovarian cajncer. Br. J. Cancer 79:933-939. Cerca con Google

McLendon RE, Wikstrand CJ, Matthews MR, Al-Baradei R, Bigner SH, Bigner DD. 2000. Glioma-associated antigen expression in oligodendroglial neoplasms. Tenascin and epidermal growth factor receptor. J Histochem Cytochem. 2000 Aug;48(8):1103-10. Cerca con Google

Mellerick DM, Fraser NW. 1987. Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state. Virology. 158(2):265-75. Cerca con Google

Mizuno M, Yoshida J, Colosi P, Kurtzman G. 1998. Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intracerebrally implanted human gliomas in mice, in conjunction with ganciclovir administration. Jpn J Cancer Res.89(1):76-80. Cerca con Google

Moolten FL. 1994. Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Cancer Gene Ther. 1(4):279-87. Cerca con Google

Mucignat-Caretta C, Caretta A. 2001. Localization of Triton-insoluble AMPc-dependent kinase type RIbeta in rat and mouse brain. J Neurocytol. 30(11):885-94. Cerca con Google

Mucignat-Caretta C, Caretta A. 2004. Regional variations in the localization of insoluble kinase A regulatory isoforms during rodent brain development. J Chem Neuroanat. 27(3):201-12. Cerca con Google

Mucignat-Caretta C, Cavaggioni A, Redaelli M, Malatesta M, Zancanaro C, Caretta A. 2008. Selective distribution of protein kinase A regulatory subunit RII{alpha} in rodent gliomas. Neuro Oncol. 10(6):958-67. Cerca con Google

Murat A, Migliavacca E, Gorlia T, Lambiv WL, Shay T, Hamou MF, de Tribolet N, Regli L, Wick W, Kouwenhoven MC, Hainfellner JA, Heppner FL, Dietrich PY, Zimmer Y, Cairncross JG, Janzer RC, Domany E, Delorenzi M, Stupp R, Hegi ME. 2008. Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol. 26(18):3015-24. Cerca con Google

Nanda D, Vogels R, Havenga M, Avezaat CJ, Bout A, Smitt PS. 2001. Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex Cerca con Google

virus-thymidine kinase. Cancer Res. 61(24):8743-50. Cerca con Google

Nadella KS, Kirschner LS. 2005. Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins. Cancer Res. 65:10307-15. Cerca con Google

Naeem K, Caywood DD, Goyal SM, Werdin RE, Murtaugh MP. 1993. Persistence of bovid herpesvirus-4 in experimentally inoculated pregnant rabbits. Microbiologica. 16 , 87–94. Cerca con Google

National Cancer Institute. 2005. REMBRANDT home page. http://rembrandt.nci.nih.gov. Accessed 2008 November 22 Vai! Cerca con Google

Neary CL, Nesterova M, Cho YS, Becker KG, Cho-Chung YS. 2004. Protein kinase A isozyme switching: eliciting differential cAMP signalling and tumor reversion. Oncogene 23:8847-56. Cerca con Google

Nowak S, Zukiel R, Barciszewska AM, Barciszewski J. 2005. The diagnosis and therapy of brain tumours. Folia Neuropathol. 43(3):193-6. Cerca con Google

Osorio FA, Reed DE, Rock DL. 1982. Experimental infection of rabbits with bovine herpesvirus-4: acute and persistent infection. Vet. Microbiol. 7 , 503–513. Cerca con Google

Palù G, Cavaggioni A, Calvi P, Franchin E, Pizzato M, Boschetto R, Parolin C, Chilosi M, Ferrini S, Zanusso A, Colombo F. 1999. Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans. Gene Ther. 6(3):330-7. Cerca con Google

Paxinos G, Watson C. 1998. The Rat Brain, in stereotaxic coordinates. Fourth Edition. Academic Press. San Diego, USA. Cerca con Google

Peterson RB, Goyal SM. 1988. Propagation and quantitation of animal herpesviruses in eight cell culture systems. Comp.Immunol. Microbiol. Infect. Dis. 11:93-98. Cerca con Google

Pulkkanen KJ, Yla-Herttuala S. 2005. Gene therapy for malignant glioma: current clinical status. Mol Ther. 2005 Oct;12(4):585-98. Cerca con Google

Rainov NG, Ren H. 2003. Clinical trials with retrovirus mediated gene therapy--what have we learned? J Neurooncol. 65(3):227-36. Cerca con Google

Rampling R, Cruickshank G, Papanastassiou V, Nicoll J, Hadley D, Brennan D, Petty R, MacLean A, Harland J, McKie E, Mabbs R, Brown M. 2000. Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther. 7(10):859-66. Cerca con Google

Ray S, Ponnathpur V, Huang Y, Tang C, Mahoney ME, Ibrado MA, Bullock G, Bhalla K. 1994. 1-?-D-Arabinofuranosylcytosine-, mitoxantrone-, and paclitaxel-induced apoptosis in HL-60 cell: improved method for detection of internucleosomal DNA fragement. Cancer Chemotherapy and Pharmacology; 34: 365-371. Cerca con Google

Redaelli M, Cavaggioni A, Mucignat-Caretta C, Cavirani S, Caretta A, Donofrio G. 2008. Trasduction of the rat brain by Bovine Herpesvirus 4. Genet. Vaccines Ther. 12; 6:6. Cerca con Google

Rich JN. 2007. Cancer stem cell in radiation resistance. Cancer Res. 67, 8980-8984. Cerca con Google

Roizman B. 1996. The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors. Proc Natl Acad Sci U S A. 93(21):11307-12. Cerca con Google

Rosenberg SA, Anderson WF, Blaese M, Hwu P, Yannelli JR, Yang JC, Topalian SL, Schwartzentruber DJ, Weber JS, Ettinghausen SE, et al. 1993. The development of gene therapy for the treatment of cancer. Ann Surg. 218(4):455-63; discussion 463-4. Cerca con Google

Salmaggi A, Boiardi A, Gelati M, Russo A, Calatozzolo C, Ciusani E, Sciacca FL, Ottolina A, Parati EA, La Porta C, Alessandri G, Marras C, Croci D, De Rossi M. 2006. Glioblastoma-derived tumorospheres identify a population of tumor stem-like cells with angiogenic potential and enhanced multidrug resistance phenotype. Glia. (8):850-60. Cerca con Google

Sathornsumetee S, Rich JN. 2008. Designer therapies for glioblastoma multiforme. Ann N Y Acad Sci. 1142:108-32. Cerca con Google

Schipper ML, Goris ML, Gambhir SS. 2007. Evaluation of herpes simplex virus 1 thymidine kinase-mediated trapping of (131)I FIAU and prodrug activation of ganciclovir as a synergistic cancer radio/chemotherapy. Mol Imaging Biol. 9(3):110-6. Cerca con Google

Schwartz JP, Costa E. 1980. Protein kinase translocation following ?-adrenergic receptor activation in C6 glioma cells. J Biol Chem. 255:2943-2948. Cerca con Google

Seligman AM, Shear MJ. 1939. Studies in carcinogenesis. VIII. Experimental production of Brain tumors in mice with methylcholanthrene. Am. J. Cancer. 37: 364–395. Cerca con Google

Serrano J, Rayo JI, Infante JR, Domínguez L, García-Bernardo L, Durán C, Fernández Portales I, Cabezudo JM. 2008. Radioguided surgery in brain tumors with thallium-201. Clin Nucl Med. 33(12):838-40. Cerca con Google

Sherr CJ, Roberts JM. 2004. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18(22):2699-711. Cerca con Google

Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB. 2003. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003 Sep 15;63(18):5821-8. Cerca con Google

Smith JA, Francis SH, Corbin JD. 1993. Autophosphorylation: a salient feature of protein kinases. Mol Cell Biochem. 127-128:51-70. Cerca con Google

Srivastava RK, Srivastava AR, Korsmeyer SJ, Nesterova M, Cho-Chung YS, Longo DL. 1998. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol Cell Biol. 18:3509-3517. Cerca con Google

Stein CS, Davidson BL. 2002. Methods Enzymol. Gene transfer to the brain using feline immunodeficiency virus-based lentivirus vectors. 2002;346:433-54. Cerca con Google

Stork PJ, Schmitt JM. 2002. Crosstalk between cAMP and MAP kinase signalling in the regulation of cell proliferation Trends Cell Biol 12:258-66. Cerca con Google

Stupp R, Mason WP, van den Bent MJ, Weller M, Fischer B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. 2005. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352(10):987-96. Cerca con Google

Smith AE, Helenius A. 2004. How viruses enter animal cells. Science. 2004 Apr 9;304(5668):237-42. Cerca con Google

Strachan T and Read AP. 2001. Genetica umana molecolare. Ed. UTET. Cerca con Google

Subak-Sharpe JH, Dargan DJ. 1998. HSV molecular biology: general aspects of herpes simplex virus molecular biology. Virus Genes.16(3):239-51. Cerca con Google

Taylor SS, Buechler TA, Yonemoto W. 1990. AMPC-dependent protein kinase: frameworkfor a diverse family of regulatory enzymes. Annu. Rev. Biochem. 59, 971-1005. Cerca con Google

Thiry E, Meurens F, Muylkens B, McVoy M, Gogev S, Thiry J, Vanderplasschen A, Epstein A, Keil G, Schynts F. 2005. Recombination in alphaherpesviruses. Rev Med Virol. 15(2):89-103. Cerca con Google

Tortora G, Ciardiello F. 2002. Protein kinase A as target for novel integrated strategies of cancer therapy. Ann N Y Acad Sci. 968:139-47. Cerca con Google

Varghese S, Rabkin SD. 2002. Oncolytic herpes simplex virus vectors for cancer virotherapy. Cancer Gene Ther. 9(12):967-78. Cerca con Google

Verma IM, Somia N. 1997. Gene therapy -- promises, problems and prospects. Nature. 18;389(6648):239-42. Cerca con Google

Vescovi AL, Galli R, Reynolds BA. 2006. Brain tumor stem cells. Nature Reviews Cancer 6, 425-436. Cerca con Google

Vile RG, Russell SJ. 1995. Retroviruses as vectors. Br Med Bull. 51(1):12-30. Cerca con Google

Wallace PK, Palmer LD, Perry-Lalley D, Bolton ES, Alexander RB, Horan PK, Yang JC, Muirhead KA. 1993. Mechanisms of adoptive immunotherapy: improved methods for in vivo tracking of tumor-infiltrating lymphocytes and lymphokine-activated killer cells. Cancer Res. 15;53(10 Suppl):2358-67. Cerca con Google

Wen PY, Kesari S. 2008. Malignant gliomas in adults. N Engl J Med. 359(5):492-507. Cerca con Google

Wilcox ME, Yang W, Senger D, Rewcastle NB, Morris DG, Brasher PM, Shi ZQ, Johnston RN, Nishikawa S, Lee PW, Forsyth PA. 2001. Reovirus as an oncolytic agent against experimental human malignant gliomas. J Natl Cancer Inst. 93(12):903-12. Cerca con Google

Wolff JE, Trillino T, Mölenkamp G, Egeler RM, Jürgens H. 1999. Chemosensitivity of glioma cells in vitro: a meta analysis. J Cancer Res Clin Oncol.;125:481-6. Cerca con Google

Zimmermann W, Broll H, Ehlers B, Buhk HJ, Rosenthal A, Goltz M. 2001. Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication. J Virol. 75(3):1186-94. Cerca con Google

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