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Pietramaggiori, Giorgio (2007) Integrazione di forze meccaniche, fattori circolanti e matrici extracellulari: un nuovo paradigma in ingegneria dei tessuti. [Ph.D. thesis]

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Abstract (english)

New therapeutical strategies are needed to face the dramatic increases in the prevalence of difficult to heal ulcers.
Using new in vivo models and a wound staging system developed ad hoc, in these studies we propose an important role of mechanical forces as non pharmacological healing inductors.
Results demonstrate that controlled regimens of mechanical forces in vivo may be used to stimulate cell proliferation and vascular remodeling, alone or in combination with more traditional approaches based on soluble factors and extracellular matrices.


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EPrint type:Ph.D. thesis
Tutor:Mazzoleni, Francesco
Supervisor:Orgill, Dennis and Wagers, Amy and Ingber, Donald and Vournakis, John
Ph.D. course:Ciclo 20 > Scuole per il 20simo ciclo > BIOLOGIA E MEDICINA DELLA RIGENERAZIONE > INGEGNERIA DEI TESSUTI E DEI TRAPIANTI
Data di deposito della tesi:01 September 2007
Anno di Pubblicazione:01 September 2007
Key Words:Wound Healing, staging system, diabetes, tissue engineering, wound regeneration, growth factors, mechanical forces, tensegrity, mechanotrasduction, chronic wounds, cost-effectiveness, Vacuum asisted closure device
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/19 Chirurgia plastica
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Scienze Mediche e Chirurgiche
Dipartimenti > pre 2012 - Dipartimento di Scienze Farmaceutiche
Codice ID:201
Depositato il:11 Nov 2008
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