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Pietramaggiori, Giorgio (2007) Integrazione di forze meccaniche, fattori circolanti e matrici extracellulari: un nuovo paradigma in ingegneria dei tessuti. [Tesi di dottorato]

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Abstract (inglese)

New therapeutical strategies are needed to face the dramatic increases in the prevalence of difficult to heal ulcers.
Using new in vivo models and a wound staging system developed ad hoc, in these studies we propose an important role of mechanical forces as non pharmacological healing inductors.
Results demonstrate that controlled regimens of mechanical forces in vivo may be used to stimulate cell proliferation and vascular remodeling, alone or in combination with more traditional approaches based on soluble factors and extracellular matrices.


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Tipo di EPrint:Tesi di dottorato
Relatore:Mazzoleni, Francesco
Correlatore:Orgill, Dennis - Wagers, Amy - Ingber, Donald - Vournakis, John
Dottorato (corsi e scuole):Ciclo 20 > Scuole per il 20simo ciclo > BIOLOGIA E MEDICINA DELLA RIGENERAZIONE > INGEGNERIA DEI TESSUTI E DEI TRAPIANTI
Data di deposito della tesi:01 Settembre 2007
Anno di Pubblicazione:01 Settembre 2007
Parole chiave (italiano / inglese):Wound Healing, staging system, diabetes, tissue engineering, wound regeneration, growth factors, mechanical forces, tensegrity, mechanotrasduction, chronic wounds, cost-effectiveness, Vacuum asisted closure device
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/19 Chirurgia plastica
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze Mediche e Chirurgiche
Dipartimenti > Dipartimento di Scienze Farmaceutiche
Codice ID:201
Depositato il:11 Nov 2008
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