Vai ai contenuti. | Spostati sulla navigazione | Spostati sulla ricerca | Vai al menu | Contatti | Accessibilità

| Crea un account

Pietramaggiori, Giorgio (2007) Integrazione di forze meccaniche, fattori circolanti e matrici extracellulari: un nuovo paradigma in ingegneria dei tessuti. [Tesi di dottorato]

Full text disponibile come:

[img]
Anteprima
Documento PDF
12Mb

Abstract (inglese)

New therapeutical strategies are needed to face the dramatic increases in the prevalence of difficult to heal ulcers.
Using new in vivo models and a wound staging system developed ad hoc, in these studies we propose an important role of mechanical forces as non pharmacological healing inductors.
Results demonstrate that controlled regimens of mechanical forces in vivo may be used to stimulate cell proliferation and vascular remodeling, alone or in combination with more traditional approaches based on soluble factors and extracellular matrices.


Statistiche Download - Aggiungi a RefWorks
Tipo di EPrint:Tesi di dottorato
Relatore:Mazzoleni, Francesco
Correlatore:Orgill, Dennis - Wagers, Amy - Ingber, Donald - Vournakis, John
Dottorato (corsi e scuole):Ciclo 20 > Scuole per il 20simo ciclo > BIOLOGIA E MEDICINA DELLA RIGENERAZIONE > INGEGNERIA DEI TESSUTI E DEI TRAPIANTI
Data di deposito della tesi:01 Settembre 2007
Anno di Pubblicazione:01 Settembre 2007
Parole chiave (italiano / inglese):Wound Healing, staging system, diabetes, tissue engineering, wound regeneration, growth factors, mechanical forces, tensegrity, mechanotrasduction, chronic wounds, cost-effectiveness, Vacuum asisted closure device
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/19 Chirurgia plastica
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze Mediche e Chirurgiche
Dipartimenti > Dipartimento di Scienze Farmaceutiche
Codice ID:201
Depositato il:11 Nov 2008
Simple Metadata
Full Metadata
EndNote Format

Bibliografia

I riferimenti della bibliografia possono essere cercati con Cerca la citazione di AIRE, copiando il titolo dell'articolo (o del libro) e la rivista (se presente) nei campi appositi di "Cerca la Citazione di AIRE".
Le url contenute in alcuni riferimenti sono raggiungibili cliccando sul link alla fine della citazione (Vai!) e tramite Google (Ricerca con Google). Il risultato dipende dalla formattazione della citazione.

1. Yannas IV. Tissue and Organ Regeneration in Adults. Springler-Verlag: New York, 2001. Cerca con Google

2. Cotran RS, Kumar V, Collins T, Robbins SL. Robbins pathologic basis of disease (6th edn). Saunders: Philadelphia, 1999; xv, 1424 p. Cerca con Google

3. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. Jama 2005;293(2): 217-228. Cerca con Google

4. Campbell LV, Graham AR, Kidd RM, Molloy HF, O'Rourke SR, Colagiuri S. The lower limb in people with diabetes. Position statement of the Australian Diabetes Society. Med J Aust 2000;173(7): 369-372. Cerca con Google

5. Ito M, Liu Y, Yang Z, Nguyen J, Liang F, Morris RJ, Cotsarelis G. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nature medicine 2005;11(12): 1351-1354. Cerca con Google

6. Watt FM. Epidermal stem cells: markers, patterning and the control of stem cell fate. Philosophical transactions of the Royal Society of London 1998;353(1370): 831-837. Cerca con Google

7. Levy V, Lindon C, Zheng Y, Harfe BD, Morgan BA. Epidermal stem cells arise from the hair follicle after wounding. Faseb J 2007. Cerca con Google

8. Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. The journal of investigative dermatology Symposium proceedings / the Society for Investigative Dermatology, Inc 2000;5(1): 40-46. Cerca con Google

9. Lorenz HP, Longaker MT. Wound Healing: repair biology and wound and scar treatment. In: Plastic Surgery, Mathes SJ (ed). Saunders Elsevier: Philadelphia, PI, 2006; 209-234. Cerca con Google

10. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341(10): 738-746. Cerca con Google

11. Broughton G, 2nd, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg 2006;117(7 Suppl): 1e-S-32e-S. Cerca con Google

12. Broughton G, 2nd, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg 2006;117(7 Suppl): 12S-34S. Cerca con Google

13. Peled Z, Galiano RG, Longaker MT. Wound Healing. In: Handbook of Plastic Surgery, Greer SE, Benhaim P, Lorenz HP, Chang J, Hedrick MH (eds). Marcel Dekker: New York, NY, 2004. Cerca con Google

14. Woolf N. Anatomia Patologica. EdiSES: Napoli, 2001. Cerca con Google

15. Mustoe TA, O'Shaughnessy K, Kloeters O. Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis. Plast Reconstr Surg 2006;117(7 Suppl): 35S-41S. Cerca con Google

16. Sparkman R. The healing of surgical wounds. In: Sparkman R, editor. Symposia on wound healing; 1985; Pearl River - New York; 1985. Cerca con Google

17. Hansen SL, Mathes SJ. Problem wounds and principles of closure. In: Plastic Surgery, Mathes SJ (ed). Saunders Elsevier: Philadelphia, PI, 2006; 901-1032. Cerca con Google

18. Harding KG, Morris HL, Patel GK. Science, medicine and the future: healing chronic wounds. BMJ (Clinical research ed 2002;324(7330): 160-163. Cerca con Google

19. Natarajan S, Williamson D, Stiltz AJ, Harding K. Advances in wound care and healing technology. American journal of clinical dermatology 2000;1(5): 269-275. Cerca con Google

20. Attinger C, Bulan EJ, Blume PA. Pharmacologic and Mechanical Management of Wounds. In: Plastic Surgery, Mathes SJ (ed). Saunders Elsevier: Philadelphia, PI, 2006; 863-900. Cerca con Google

21. Martinowitz U, Spotnitz WD. Fibrin tissue adhesives. Thromb Haemost 1997;78(1): 661-666. Cerca con Google

22. Folkman J, Browder T, Palmblad J. Angiogenesis research: guidelines for translation to clinical application. Thromb Haemost 2001;86(1): 23-33. Cerca con Google

23. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, Bunting S, Steinmetz HG, Gurtner GC. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 2004;164(6): 1935-1947. Cerca con Google

24. Kirchner LM, Meerbaum SO, Gruber BS, Knoll AK, Bulgrin J, Taylor RA, Schmidt SP. Effects of vascular endothelial growth factor on wound closure rates in the genetically diabetic mouse model. Wound Repair Regen 2003;11(2): 127-131. Cerca con Google

25. Wieman TJ. Clinical efficacy of becaplermin (rhPDGF-BB) gel. Becaplermin Gel Studies Group. Am J Surg 1998;176(2A Suppl): 74S-79S. Cerca con Google

26. Beer HD, Longaker MT, Werner S. Reduced expression of PDGF and PDGF receptors during impaired wound healing. J Invest Dermatol 1997;109(2): 132-138. Cerca con Google

27. Lauer G, Sollberg S, Cole M, Flamme I, Sturzebecher J, Mann K, Krieg T, Eming SA. Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds. J Invest Dermatol 2000;115(1): 12-18. Cerca con Google

28. Marikovsky M, Vogt P, Eriksson E, Rubin JS, Taylor WG, Joachim S, Klagsbrun M. Wound fluid-derived heparin-binding EGF-like growth factor (HB-EGF) is synergistic with insulin-like growth factor-I for Balb/MK keratinocyte proliferation. J Invest Dermatol 1996;106(4): 616-621. Cerca con Google

29. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004;114(6): 1502-1508. Cerca con Google

30. Bhanot S, Alex JC. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg 2002;18(1): 27-33. Cerca con Google

31. Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg 1986;204(3): 322-330. Cerca con Google

32. Margolis DJ, Kantor J, Santanna J, Strom BL, Berlin JA. Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 2001;24(3): 483-488. Cerca con Google

33. Frechette JP, Martineau I, Gagnon G. Platelet-rich plasmas: growth factor content and roles in wound healing. J Dent Res 2005;84(5): 434-439. Cerca con Google

34. Krupski WC, Reilly LM, Perez S, Moss KM, Crombleholme PA, Rapp JH. A prospective randomized trial of autologous platelet-derived wound healing factors for treatment of chronic nonhealing wounds: a preliminary report. J Vasc Surg 1991;14(4): 526-532; discussion 532-526. Cerca con Google

35. Stacey MC, Mata SD, Trengove NJ, Mather CA. Randomised double-blind placebo controlled trial of topical autologous platelet lysate in venous ulcer healing. Eur J Vasc Endovasc Surg 2000;20(3): 296-301. Cerca con Google

36. Steed D, Goslen B, Hambley R, Abell E, Hebda P, Webster M. Clinical trials with purified platelet releasate. Prog Clin Biol Res 1991;365: 103-113. Cerca con Google

37. Steed DL, Goslen JB, Holloway GA, Malone JM, Bunt TJ, Webster MW. Randomized prospective double-blind trial in healing chronic diabetic foot ulcers. CT-102 activated platelet supernatant, topical versus placebo. Diabetes Care 1992;15(11): 1598-1604. Cerca con Google

38. Murphy S. Platelet storage for transfusion. Semin Hematol 1985;22(3): 165-177. Cerca con Google

39. Vournakis JN, Demcheva M, Whitson A, Guirca R, Pariser ER. Isolation, purification, and characterization of poly-N-acetyl glucosamine use as a hemostatic agent. J Trauma 2004;57(1 Suppl): S2-6. Cerca con Google

40. Najjar SF, Healey NA, Healey CM, McGarry T, Khan B, Thatte HS, Khuri SF. Evaluation of poly-N-acetyl glucosamine as a hemostatic agent in patients undergoing cardiac catheterization: a double-blind, randomized study. J Trauma 2004;57(1 Suppl): S38-41. Cerca con Google

41. Fazio VW, Cohen Z, Fleshman JW, van Goor H, Bauer JJ, Wolff BG, Corman M, Beart RW, Jr., Wexner SD, Becker JM, Monson JR, Kaufman HS, Beck DE, Bailey HR, Ludwig KA, Stamos MJ, Darzi A, Bleday R, Dorazio R, Madoff RD, Smith LE, Gearhart S, Lillemoe K, Gohl J. Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Dis Colon Rectum 2006;49(1): 1-11. Cerca con Google

42. Pena Ede L, Sala S, Rovira JC, Schmidt RF, Belmonte C. Elastoviscous substances with analgesic effects on joint pain reduce stretch-activated ion channel activity in vitro. Pain 2002;99(3): 501-508. Cerca con Google

43. Orgill DP, Straus FH, 2nd, Lee RC. The use of collagen-GAG membranes in reconstructive surgery. Ann N Y Acad Sci 1999;888: 233-248. Cerca con Google

44. Malette WG, Quigley HJ, Gaines RD, Johnson ND, Rainer WG. Chitosan: a new hemostatic. Ann Thorac Surg 1983;36(1): 55-58. Cerca con Google

45. Fischer TH, Connolly R, Thatte HS, Schwaitzberg SS. Comparison of structural and hemostatic properties of the poly-N-acetyl glucosamine Syvek Patch with products containing chitosan. Microsc Res Tech 2004;63(3): 168-174. Cerca con Google

46. Thatte HS, Zagarins S, Khuri SF, Fischer TH. Mechanisms of poly-N-acetyl glucosamine polymer-mediated hemostasis: platelet interactions. J Trauma 2004;57(1 Suppl): S13-21. Cerca con Google

47. Thatte HS, Zagarins SE, Amiji M, Khuri SF. Poly-N-acetyl glucosamine-mediated red blood cell interactions. J Trauma 2004;57(1 Suppl): S7-12. Cerca con Google

48. Fischer TH, Thatte HS, Nichols TC, Bender-Neal DE, Bellinger AD, Vournakis JN. Synergistic platelet integrin signaling and factor XII activation in poly-N-acetyl glucosamine fiber-mediated hemostasis. Biomaterials 2005;26(27): 5433-5443. Cerca con Google

49. Valeri CR, Srey R, Tilahun D, Ragno G. In vitro effects of poly-N-acetyl glucosamine on the activation of platelets in platelet-rich plasma with and without red blood cells. J Trauma 2004;57(1 Suppl): S22-25; discussion S25. Cerca con Google

50. Browder T, Folkman J, Pirie-Shepherd S. The hemostatic system as a regulator of angiogenesis. J Biol Chem 2000;275(3): 1521-1524. Cerca con Google

51. Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A 2006;103(4): 855-860. Cerca con Google

52. Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL. Physiological migration of hematopoietic stem and progenitor cells. Science 2001;294(5548): 1933-1936. Cerca con Google

53. Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969;217(5): 1298-1304. Cerca con Google

54. Fruhbeck G, Gomez-Ambrosi J. Rationale for the existence of additional adipostatic hormones. Faseb J 2001;15(11): 1996-2006. Cerca con Google

55. Yannas IV. Facts and theories of induced organ regeneration. Advances in biochemical engineering/biotechnology 2005;93: 1-38. Cerca con Google

56. Yannas IV. Similarities and differences between induced organ regeneration in adults and early foetal regeneration. Journal of the Royal Society, Interface / the Royal Society 2005;2(5): 403-417. Cerca con Google

57. Yannas IV, Burke JF, Warpehoski M, Stasikelis P, Skrabut EM, Orgill D, Giard DJ. Prompt, long-term functional replacement of skin. Transactions - American Society for Artificial Internal Organs 1981;27: 19-23. Cerca con Google

58. Yannas IV. Tissue and Organ Regeneration in Adults Springer-Verlag New York, Inc.: New York, 2001. Cerca con Google

59. Ophof R, Maltha JC, Von den Hoff JW, Kuijpers-Jagtman AM. Histologic evaluation of skin-derived and collagen-based substrates implanted in palatal wounds. Wound Repair Regen 2004;12(5): 528-538. Cerca con Google

60. Levy D, et al. Cymetra: A Treatment Option for Refractory Ulcers. Wounds 2004;16(12): 359-363. Cerca con Google

61. Banta MN, Eaglstein WH, Kirsner RS. Healing of refractory sinus tracts by dermal matrix injection with Cymetra. Dermatol Surg 2003;29(8): 863-866. Cerca con Google

62. Lorber M, Milobsky SA. Stretching of the skin in vivo. A method of influencing cell division and migration in the rat epidermis. The Journal of investigative dermatology 1968;51(5): 395-402. Cerca con Google

63. Mackenzie IC. Does toothbrushing affect gingival keratinization? Proc R Soc Med 1972;65(12): 1127-1131. Cerca con Google

64. Mackenzie IC. The effects of frictional stimulation on mouse ear epidermis. I. Cell proliferation. The Journal of investigative dermatology 1974;62(2): 80-85. Cerca con Google

65. Bullough WS, Laurence EB. The control of epidermal mitotic activity in the mouse. Proceedings of the Royal Society of London Series B, Containing papers of a Biological character 1960;151: 517-536. Cerca con Google

66. Francis AJ, Marks R. Factors responsible for dermally induced epidermal hyperplasia. Archives for dermatological research 1977;258(3): 275-280. Cerca con Google

67. Curtis AS, Seehar GM. The control of cell division by tension or diffusion. Nature 1978;274(5666): 52-53. Cerca con Google

68. Squier CA. The stretching of mouse skin in vivo: effect on epidermal proliferation and thickness. The Journal of investigative dermatology 1980;74(2): 68-71. Cerca con Google

69. Squier CA. The effect of stretching on formation of myofibroblasts in mouse skin. Cell Tissue Res 1981;220(2): 325-335. Cerca con Google

70. Brunette DM. Mechanical stretching increases the number of epithelial cells synthesizing DNA in culture. J Cell Sci 1984;69: 35-45. Cerca con Google

71. Austad ED, Pasyk KA, McClatchey KD, Cherry GW. Histomorphologic evaluation of guinea pig skin and soft tissue after controlled tissue expansion. Plast Reconstr Surg 1982;70(6): 704-710. Cerca con Google

72. Olenius M, Dalsgaard CJ, Wickman M. Mitotic activity in expanded human skin. Plast Reconstr Surg 1993;91(2): 213-216. Cerca con Google

73. Austad ED, Thomas SB, Pasyk K. Tissue expansion: dividend or loan? Plast Reconstr Surg 1986;78(1): 63-67. Cerca con Google

74. Johnson TM, Lowe L, Brown MD, Sullivan MJ, Nelson BR. Histology and physiology of tissue expansion. The Journal of dermatologic surgery and oncology 1993;19(12): 1074-1078. Cerca con Google

75. Argenta LC, Marks M W. Principles of Tissue Expansion. In: Plastic Surgery, Mathes SJ (ed), vol 1. Saunders Elsevier: Philadelphia, PA, 2006; 539-568. Cerca con Google

76. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. Clinical orthopaedics and related research 1989(238): 249-281. Cerca con Google

77. Gugenheim JJ, Jr. The Ilizarov method. Orthopedic and soft tissue applications. Clinics in plastic surgery 1998;25(4): 567-578. Cerca con Google

78. Lerner A, Ullmann Y, Stein H, Peled IJ. Using the Ilizarov external fixation device for skin expansion. Annals of plastic surgery 2000;45(5): 535-537. Cerca con Google

79. Cherry GW, Austad E, Pasyk K, McClatchey K, Rohrich RJ. Increased survival and vascularity of random-pattern skin flaps elevated in controlled, expanded skin. Plast Reconstr Surg 1983;72(5): 680-687. Cerca con Google

80. Malata CM, Williams NW, Sharpe DT. Tissue expansion: an overview. Journal of wound care 1995;4(1): 37-44. Cerca con Google

81. Marks MW, Argenta LC, Thornton JW. Rapid expansion: experimental and clinical experience. Clinics in plastic surgery 1987;14(3): 455-463. Cerca con Google

82. De Filippo RE, Atala A. Stretch and growth: the molecular and physiologic influences of tissue expansion. Plast Reconstr Surg 2002;109(7): 2450-2462. Cerca con Google

83. Watt FM. Role of integrins in regulating epidermal adhesion, growth and differentiation. The EMBO journal 2002;21(15): 3919-3926. Cerca con Google

84. Torsoni AS, Constancio SS, Nadruz W, Jr., Hanks SK, Franchini KG. Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circulation research 2003;93(2): 140-147. Cerca con Google

85. Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcified tissue international 1995;57(5): 344-358. Cerca con Google

86. Hamill OP, McBride DW, Jr. The pharmacology of mechanogated membrane ion channels. Pharmacological reviews 1996;48(2): 231-252. Cerca con Google

87. Vandenburgh HH. Mechanical forces and their second messengers in stimulating cell growth in vitro. The American journal of physiology 1992;262(3 Pt 2): R350-355. Cerca con Google

88. Yano S, Komine M, Fujimoto M, Okochi H, Tamaki K. Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes. The Journal of investigative dermatology 2004;122(3): 783-790. Cerca con Google

89. Takei T, Mills I, Arai K, Sumpio BE. Molecular basis for tissue expansion: clinical implications for the surgeon. Plast Reconstr Surg 1998;102(1): 247-258. Cerca con Google

90. Silver FH, Siperko LM, Seehra GP. Mechanobiology of force transduction in dermal tissue. Skin Res Technol 2003;9(1): 3-23. Cerca con Google

91. Folkman J, Greenspan HP. Influence of geometry on control of cell growth. Biochimica et biophysica acta 1975;417(3-4): 211-236. Cerca con Google

92. Folkman J, Moscona A. Role of cell shape in growth control. Nature 1978;273(5661): 345-349. Cerca con Google

93. Structure and tensegrity. www.kennethsnelson.net. Vai! Cerca con Google

94. Ingber DE. Tensegrity I. Cell structure and hierarchical systems biology. J Cell Sci 2003;116(Pt 7): 1157-1173. Cerca con Google

95. Ingber D. How cells (might) sense microgravity. Faseb J 1999;13 Suppl: S3-15. Cerca con Google

96. Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science (New York, NY 1993;260(5111): 1124-1127. Cerca con Google

97. Wang N, Ingber DE. Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension. Biophysical journal 1994;66(6): 2181-2189. Cerca con Google

98. Wang N, Ingber DE. Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry. Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(7-8): 327-335. Cerca con Google

99. Maniotis AJ, Chen CS, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proceedings of the National Academy of Sciences of the United States of America 1997;94(3): 849-854. Cerca con Google

100. Wang N, Naruse K, Stamenovic D, Fredberg JJ, Mijailovich SM, Tolic-Norrelykke IM, Polte T, Mannix R, Ingber DE. Mechanical behavior in living cells consistent with the tensegrity model. Proceedings of the National Academy of Sciences of the United States of America 2001;98(14): 7765-7770. Cerca con Google

101. Ingber DE. Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton. J Cell Sci 1993;104 ( Pt 3): 613-627. Cerca con Google

102. Hubmayr RD, Shore SA, Fredberg JJ, Planus E, Panettieri RA, Jr., Moller W, Heyder J, Wang N. Pharmacological activation changes stiffness of cultured human airway smooth muscle cells. The American journal of physiology 1996;271(5 Pt 1): C1660-1668. Cerca con Google

103. Stamenovic D, Mijailovich SM, Tolic-Norrelykke IM, Chen J, Wang N. Cell prestress. II. Contribution of microtubules. American journal of physiology 2002;282(3): C617-624. Cerca con Google

104. Wang N, Tolic-Norrelykke IM, Chen J, Mijailovich SM, Butler JP, Fredberg JJ, Stamenovic D. Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. American journal of physiology 2002;282(3): C606-616. Cerca con Google

105. Kolodney MS, Wysolmerski RB. Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study. The Journal of cell biology 1992;117(1): 73-82. Cerca con Google

106. Kolodney MS, Elson EL. Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain. Proceedings of the National Academy of Sciences of the United States of America 1995;92(22): 10252-10256. Cerca con Google

107. Mizushima-Sugano J, Maeda T, Miki-Noumura T. Flexural rigidity of singlet microtubules estimated from statistical analysis of their contour lengths and end-to-end distances. Biochimica et biophysica acta 1983;755(2): 257-262. Cerca con Google

108. Ruoslahti E. Stretching is good for a cell. Science (New York, NY 1997;276(5317): 1345-1346. Cerca con Google

109. Miyamoto S, Akiyama SK, Yamada KM. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science (New York, NY 1995;267(5199): 883-885. Cerca con Google

110. McNamee HP, Liley HG, Ingber DE. Integrin-dependent control of inositol lipid synthesis in vascular endothelial cells and smooth muscle cells. Experimental cell research 1996;224(1): 116-122. Cerca con Google

111. Ingber DE. Tensegrity: the architectural basis of cellular mechanotransduction. Annual review of physiology 1997;59: 575-599. Cerca con Google

112. Ingber DE. Tensegrity II. How structural networks influence cellular information processing networks. J Cell Sci 2003;116(Pt 8): 1397-1408. Cerca con Google

113. Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE. Geometric control of cell life and death. Science (New York, NY 1997;276(5317): 1425-1428. Cerca con Google

114. Huang S, Chen CS, Ingber DE. Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell 1998;9(11): 3179-3193. Cerca con Google

115. Huang S, Ingber DE. The structural and mechanical complexity of cell-growth control. Nat Cell Biol 1999;1(5): E131-138. Cerca con Google

116. Dike LE, Ingber DE. Integrin-dependent induction of early growth response genes in capillary endothelial cells. J Cell Sci 1996;109 ( Pt 12): 2855-2863. Cerca con Google

117. www.idf.org/home/index.cfm. Vai! Cerca con Google

118. Parker KK, Brock AL, Brangwynne C, Mannix RJ, Wang N, Ostuni E, Geisse NA, Adams JC, Whitesides GM, Ingber DE. Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. Faseb J 2002;16(10): 1195-1204. Cerca con Google

119. Argenta LC, Morykwas MJ, Marks MW, DeFranzo AJ, Molnar JA, David LR. Vacuum-assisted closure: state of clinic art. Plast Reconstr Surg 2006;117(7 Suppl): 127S-142S. Cerca con Google

120. Greene AK, Puder M, Roy R, Arsenault D, Kwei S, Moses MA, Orgill DP. Microdeformational wound therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients. Ann Plast Surg 2006;56(4): 418-422. Cerca con Google

121. Smith A (ed). V.A.C. Therapy clinical guidelines. KCI Lincensing Inc.: San Antonio, Texas, 2006. Cerca con Google

122. Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Annals of plastic surgery 1997;38(6): 563-576; discussion 577. Cerca con Google

123. Philbeck TE, Jr., Whittington KT, Millsap MH, Briones RB, Wight DG, Schroeder WJ. The clinical and cost effectiveness of externally applied negative pressure wound therapy in the treatment of wounds in home healthcare Medicare patients. Ostomy/wound management 1999;45(11): 41-50. Cerca con Google

124. Evans D, Land L. Topical negative pressure for treating chronic wounds: a systematic review. British journal of plastic surgery 2001;54(3): 238-242. Cerca con Google

125. Braakenburg A, Obdeijn MC, Feitz R, van Rooij IA, van Griethuysen AJ, Klinkenbijl JH. The clinical efficacy and cost effectiveness of the vacuum-assisted closure technique in the management of acute and chronic wounds: a randomized controlled trial. Plast Reconstr Surg 2006;118(2): 390-397; discussion 398-400. Cerca con Google

126. Moues CM, Vos MC, van den Bemd GJ, Stijnen T, Hovius SE. Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial. Wound Repair Regen 2004;12(1): 11-17. Cerca con Google

127. Venturi ML, Attinger CE, Mesbahi AN, Hess CL, Graw KS. Mechanisms and clinical applications of the vacuum-assisted closure (VAC) Device: a review. American journal of clinical dermatology 2005;6(3): 185-194. Cerca con Google

128. Genecov DG, Schneider AM, Morykwas MJ, Parker D, White WL, Argenta LC. A controlled subatmospheric pressure dressing increases the rate of skin graft donor site reepithelialization. Annals of plastic surgery 1998;40(3): 219-225. Cerca con Google

129. Miller Q, Bird E, Bird K, Meschter C, Moulton MJ. Effect of subatmospheric pressure on the acute healing wound. Current Surgery 2004;61(2): 205-208. Cerca con Google

130. Morykwas MJ, Simpson J, Punger K, Argenta A, Kremers L, Argenta J. Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg 2006;117(7 Suppl): 121S-126S. Cerca con Google

131. Mendonca DA, Papini R, Price PE. Negative-pressure wound therapy: a snapshot of the evidence. In; 2006. p. 261-271. Cerca con Google

132. Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg 2004;114(5): 1086-1096; discussion 1097-1088. Cerca con Google

133. Jacobi J, Jang JJ, Sundram U, Dayoub H, Fajardo LF, Cooke JP. Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. The American journal of pathology 2002;161(1): 97-104. Cerca con Google

134. Michaels Jt, Dobryansky M, Galiano RD, Bhatt KA, Ashinoff R, Ceradini DJ, Gurtner GC. Topical vascular endothelial growth factor reverses delayed wound healing secondary to angiogenesis inhibitor administration. Wound Repair Regen 2005;13(5): 506-512. Cerca con Google

135. Maloney BP, Murphy BA, Cole HP, 3rd. Cymetra. Facial Plast Surg 2004;20(2): 129-134. Cerca con Google

136. ME B. Technical Manual. 14 ed. Bethesda, MD: American Association of Blood Banks Cerca con Google

2002. Cerca con Google

137. Pietramaggiori G, Kaipainen A, Czeczuga JM, Wagner CT, Orgill DP. Freeze-dried platelet-rich plasma shows beneficial healing properties in chronic wounds. Wound Repair Regen 2006;14(5): 573-580. Cerca con Google

138. Saldalamacchia G, Lapice E, Cuomo V, De Feo E, D'Agostino E, Rivellese AA, Vaccaro O. A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers. Nutr Metab Cardiovasc Dis 2004;14(6): 395-396. Cerca con Google

139. Sanders R. Torsional elasticity of human skin in vivo. Pflugers Arch 1973;342(3): 255-260. Cerca con Google

140. Pietramaggiori A, Kaipainen A, Ho D, Orser C, Pebley W, Rudolph A, DP. O. Trehalose lyophilized platelets for wound healing. Wound Repair Regen 2006(in press). Cerca con Google

141. Wilhelmi BJ, Blackwell SJ, Mancoll JS, Phillips LG. Creep vs. stretch: a review of the viscoelastic properties of skin. Ann Plast Surg 1998;41(2): 215-219. Cerca con Google

142. Greenhalgh DG. Models of wound healing. J Burn Care Rehabil 2005;26(4): 293-305. Cerca con Google

143. Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast Reconstr Surg 2006;117(7 Suppl): 143S-149S; discussion 150S-151S. Cerca con Google

144. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, Weissman IL. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A 2005;102(26): 9194-9199. Cerca con Google

145. Ashcroft GS, Horan MA, Ferguson MW. The effects of ageing on cutaneous wound healing in mammals. J Anat 1995;187 ( Pt 1): 1-26. Cerca con Google

146. Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A 2006. Cerca con Google

147. Blackman BR, Garcia-Cardena G, Gimbrone MA, Jr. A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J Biomech Eng 2002;124(4): 397-407. Cerca con Google

Download statistics

Solo per lo Staff dell Archivio: Modifica questo record