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Agostini, Stefania (2008) Il sistema [MV(N)(PNP)]2+ (M=Tc-99m, Re-188) nella scintigrafia miocardica e in medicina nucleare molecolare. [Ph.D. thesis]

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Abstract (english)

Recently we have described the synthesis of a new class of asymmetrical nitrido complexes, based on the chemical properties of the substitution labile [Tc(N)X2(PNP)]2+ complex (PNP=aminodiphosphine, X=Cl, OH, H2O), which represent an interesting opportunity in design both perfusion and target-specific radiopharmaceuticals.
According to this strategy, the strong electrophylic [Tc(N)(PNP)]2+ moiety efficiently reacts with bifunctional ligands (XY) carrying coordinating atoms π-donors such as S, O or N, to afford asymmetrical nitrido heterocomplexes of the type [Tc(N)(XY)(PNP)]0/+.
In this work, studies to demonstrate the effective applicability of this technology to the preparation of perfusion and target-specific agents are reported, through synthesis and biological evaluation of:
1) 99mTc-nitrido complexes as potential myocardial imaging tracers,
2) 99mTc-nitrido complexes as potential target-specific agents, for imaging CCK-B receptor,
3) 188Re-nitrido complexes for therapeutic targeting.


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EPrint type:Ph.D. thesis
Tutor:Bandoli, Giuliano
Supervisor:Bolzati, Cristina
Ph.D. course:Ciclo 20 > Scuole per il 20simo ciclo > SCIENZE MOLECOLARI > SCIENZE FARMACEUTICHE
Data di deposito della tesi:January 2008
Anno di Pubblicazione:January 2008
Key Words:azoturo complessi, Tc-99m, Re-188, leganti amminodifosfinici
Settori scientifico-disciplinari MIUR:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Scienze Farmaceutiche
Codice ID:295
Depositato il:10 Oct 2008
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