Zorzato, Gloria (2008) Produzione di microparticelle a base di acido ialuronico per il rilascio di fattori di crescita nella cura di ulcere. [Ph.D. thesis] Full text disponibile come:
Abstract (english)The present study describes the production of hyaluronan based porous microparticles by a semi-continuous gas antisolvent (GAS) precipitation process to be used as a growth factor delivery system for in vivo treatment of ulcers. Operative process conditions, such as pressure, nozzle diameter and HYAFF® solution concentrations, were adjusted to optimize particle production in terms of morphology and size. Scanning electron microscopy and light scattering demonstrated that porous nano- structured particles with a size of 300-900 nm had a high specific surface suitable for absorption of growth factors from the aqueous environment within the polymeric matrix. Water acted as a plasticizer, enhancing growth factor absorption. The absorption process was developed using a fluorescent dye and growth factors PDGF and TGF-ß. Immunohistochemical analysis confirmed the high efficiency of absorption of growth factors and a mathematical model was generated to quantify and qualify the in vitro kinetics of growth factor release from the polymeric matrix.
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