Go to the content. | Move to the navigation | Go to the site search | Go to the menu | Contacts | Accessibility

| Create Account

Vidalino, Laura (2008) Espressione di membrana della serpina SCCA e deregolazione dei linfociti B: studio in pazienti con infezione virale ed in pazienti con Lupus Eritematoso sistemico. [Ph.D. thesis]

Full text disponibile come:

[img]
Preview
Documento PDF
990Kb

Abstract (english)

Background.HCV infection may progress to a broad spectrum of liver diseases, as a consequence of complex interactions between viral and host factors. The role of B cells in HCV infection is largely unknown. Systemic Lupus erythematosus (SLE) is a systemic autoimmune disease. B cell deregulation represents a central feature both of HCV infection and SLE. SCCA, an ov-serpin, found in majority of primary liver cancers, is detectable in lymphocytes. To date, the potential involvement of SCCA in the pathogenesis of SLE and in HCV have not yet been investigated.
Aim. To characterize SCCA expression in peripheral blood mononuclear cells (PBMC) in HCV infected and in SLE patients.
Patients and methods. 45 HCV patients (14 with chronic hepatitis, 17 with cirrhosis and 14 with hepatocellular carcinoma), 12 with LES and 24 healthy controls were analyzed. Surface expression of SCCA in PBMC was assessed by FACS analysis. To define SCCA co-expression in B lymphocytes, different activation molecules (CD27, CD69, CD71, CD86 and CXCR3) were simultaneously evaluated. In purified B cells, SCCA RNA was quantified by Real Time PCR and localization of SCCA was defined by confocal microscopy.
Results. FACS analysis and confocal microscopy showed that SCCA was expressed on the surface of B lymphocytes in 68% of normal subjects and in 32% of HCV patients (p<0.03). In SLE patients SCCA resulted not expressed in any of the patients (p=0.0000). Real Time PCR confirmed higher levels of transcription of the serpin in purified B cells of control subjects (p=0.0041). SCCA positivity was significantly associated with CD27 reactivity.
Conclusions. HCV infection is associated with a marked reduction of SCCA being associated with the memory B cells molecule CD27 on B lymphocytes surface, suggesting a possible involvement of SCCA in B cell defects in HCV and in SLE. In SLE patients the serpin is not expressed on the surface of B lymphocytes. These findings suggest a possible involvement of SCCA in the deregulation of B cell reactivity, during HCV infection and SLE.
.


Statistiche Download - Aggiungi a RefWorks
EPrint type:Ph.D. thesis
Tutor:Doria, Andrea
Supervisor:Pontisso, Patrizia
Ph.D. course:Ciclo 20 > Scuole per il 20simo ciclo > SCIENZE MEDICHE, CLINICHE E SPERIMENTALI > REUMATOLOGIA CLINICA E SPERIMENTALE
Data di deposito della tesi:2008
Anno di Pubblicazione:2008
Key Words:Squamous Cell Carcinoma Antigen (SCCA), linfociti B, virus dell'epatite C (HCV), Lupus Eritematoso Sistemico (LES)
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/16 Reumatologia
Area 06 - Scienze mediche > MED/09 Medicina interna
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Medicina Clinica e Sperimentale
Codice ID:357
Depositato il:09 Oct 2008
Simple Metadata
Full Metadata
EndNote Format

Bibliografia

I riferimenti della bibliografia possono essere cercati con Cerca la citazione di AIRE, copiando il titolo dell'articolo (o del libro) e la rivista (se presente) nei campi appositi di "Cerca la Citazione di AIRE".
Le url contenute in alcuni riferimenti sono raggiungibili cliccando sul link alla fine della citazione (Vai!) e tramite Google (Ricerca con Google). Il risultato dipende dalla formattazione della citazione.

1. Alam R., Gorska M. Lymphocytes. Journ Allergy and Clin Immun. 2003; 111: 476 - 485. Cerca con Google

2. Carding K. L., Egan P. J. Gammadelta T cells function: functional plasticity and heterogeneity. Nat Rev Immunol. 2002; 2: 336 - 345. Cerca con Google

3. Calame K. L. Plasma cells: finding new light at the end of B cell development. Nat Immunol. 2001; 2: 1103 - 1108. Cerca con Google

4. Walker L. S., Abbas A. K. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol. 2002; 2: 11 - 19. Cerca con Google

5. Shevach E. M., McHugh R. S., Piccirillo C. A., Thornton A. M. Control of Tcell activation by CD4+ CD25+ suppressor T cells. Immunol Rev. 2001; 182: 58 - 67. Cerca con Google

6. Nemazee D. Receptor selection in B and T lymphocytes. Annu Rev Immunol.2000; 18: 19 - 51. Cerca con Google

7. Delves P., Martin S., Burton D., Roitt I. Roitt's Essential Immunology. Blackwell Publishing. 2003 (11th edition). Cerca con Google

8. Hesslein D. G., Schatz D. G. Factors and forces controlling V(D)J recombination. Adv Immunol. 2000; 18: 19 - 51. Cerca con Google

9. Hennecke J., Wiley D. C. T cell receptor-MHC interactions up close. Cell. 2001; 104: 1 - 4. Cerca con Google

10. Cambier J. C. Inhibitory receptors abound? Proc Natl Acad Sci USA. 1997; 94: 5993 - 5995. Cerca con Google

11. Chaplin D. Overview of the human immune responses. Journ Allergy and Clin Immun. 2005; 117: 430 - 435. Cerca con Google

12. Hesslein D. G., Schatz D. G. Factors and forces controlling V(D)J recombination. Adv Immunol. 2001; 18: 19 - 51. Cerca con Google

13. Gauld S. B., Dal Porto J. M., Cambier J. C. B cell antigen receptor signaling: roles in cell development and disease. Science. 2002; 296: 1641 - 1642. Cerca con Google

14. Applequist S. E., Wallin R. P., Ljunggren H. G. Variable expression of Toll-like receptor in murine innate and adaptative immune cell lines. Int. Immunol. 1998; 28: 4188 - 4197. Cerca con Google

15. Harris D. P., Haynes L., Sayles P.C., Duso D. K., Eaton S. M., Lepak N. M. et al., Nat Immunol. 2000; 1: 475 - 482. Cerca con Google

16. Viau M., Zouali M. B-lymphocytes, innate immunity and autoimmunity. Clin Immunol. 2005; 114: 17 - 26. Cerca con Google

17. Dustin M. L., Dustin L. B. The immunological relay race: B cells take antigen by synapse. Nat Immunol. 2001; 2: 480 - 482. Cerca con Google

18. Mohan C., Morel L., Yang P., Wakeland E. K. Accumulation of splenic B-1a cell with potent antigen-presenting capability NZM2410 lupus-prone mice. Arthritis Rheum. 1998; 41: 1652 - 1662. Cerca con Google

19. Schultz K. R., Klarnet J. P., Gieni R. S., HayGlass K. T., Greenberg P. D. Science. 1990; 249: 921 - 923. Cerca con Google

20. Cerny A., Zinkornagel R. M., Grosccurth P. Development of follicular dendritic cells in lymph nodes of B-cell depleted mice. Cell Tissue Rev. 1998; 254: 449 - 454. Cerca con Google

21. Lloyd A. R., Jagger E., Post J. J., Crooks L., Rawlison W. D., Hahn Y. S., Ffrench R. Host and viral factors uin the immunopathogenesis of primary hepatitis C infection. Immunol and Cell Biol. 2007; 85: 24 - 32. Cerca con Google

22. Rehermann B., Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol. 2005; 5: 215 - 229. Cerca con Google

23. Blight K., Rowland R., Hall P. D., Lesniewski R. R., Trowbridge R.,. LaBrooy J. T, Gowans E. J. Immunohistochemical detection of the NS4 antigen of hepatitis C virus and its relation to histopathology. Am J Pathol. 1993; 143: 1568 - 1573. Cerca con Google

24. Alberti A., L. Chemello, L. Benvegnù. Natural history of hepatitis C. J Hepatol. 1999; 31: 17 - 24. Cerca con Google

25. Bertoletti A., C. Ferrari.. Kinetics of the immune response during HBV and HCV infection. Hepatology. 2003; 38: 4 - 13. Cerca con Google

26. Szabo G., Dolganiuc A. HCV immunopathogenesis: virus-induced strategies against host immunity. Clin Liver Dis. 2006; 753 - 771. Cerca con Google

27. Kanto T., N. Hayashi. Immunopathogenesis of hepatits C virus infection: multifaceted strategies subverting innate and adaptive immunity. Intern. Med. 2006; 45: 183 - 191. Cerca con Google

28. Barrett S., M. Sweeney, J. Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gatroenterol Hepatol 2005; 17: 1089 - 1097. Cerca con Google

29. Spengler U., J. Nattermann. Immunopathogenesis in hepatitis C virus cirrhosis. Clin Science. 2007; 112: 141 - 155. Cerca con Google

30. Thimme R., K. M. Oldach, K. M.Chang, C. Steiger, S. C. Ray, F. V. Chisari. Determinants of viral clearance and persistance during acute hepatitis C virus infection. J Exp Med 2001; 194: 1395 - 1406. Cerca con Google

31. Neumann-Haefelin C., H. E. Blum, F. V. Chisari, R. Thimme. T cell response in hepatitis C virus infection. J Clin Virol. 2005; 32: 75 - 85. Cerca con Google

32. Cerino A., L. Timo, G. Comolli, R. Cividini, R. Gulminetti, V. Barnaba, M. U. Mondelli. A.I.S.F. Annual Meeting. B lymphocytes activation in chronic HCV infection: possible implications for autoimmune and lymphoproliferative disorders [abstract]. Dig. and Liv. Dis. 2006; 38: A53 - A54. Cerca con Google

33. Mondelli M. U., Zorzoli I., Cerino A., Cividini A., Bissolati M., segagni L., Perfetti V., Anesi F., Garini P., Merlini G. P. Clonality and specificity of cryoglobulins associated with HCV: pathophysiological implications. J Hepat. 1998; 29: 879 - 886. Cerca con Google

34. Mondelli M. U. Multifaceted functions of B cells in chronic hepatitis C virus infection. Antiv Research. 2003; 60: 111 - 115. Cerca con Google

35. Li C., Candotti D., Allain J. P. Production and characterization of monoclonal antibodies specific for a conserved epitope within hepatitis c virus hypervariable region 1. J Virol. 2001; 75: 12412 - 12420. Cerca con Google

36. Selva-O’Callaghan A., Rodriguez-Pardo D., Sanchez-Sitjes L., Matas-Percas L., Solans-Laque R., Bosch-Gil J. A., Vilardell-Tarres M. Hepatitis C virus infection, Sjögren’s syndrome and non-Hodgkin’s lymphoma. Arthritis Rheum. 1999; 42: 2489 - 2490. Cerca con Google

37. Quinn F. R., Chan C. H., Hadlock K. G., Foung S. K., Flint M., Levy S. The Bcell receptor pf a hepatitis C virus (HCV)-associated non-Hodgkin lymphomagenesis. Blood. 2001; 98: 3745 – 3749. Cerca con Google

38. Zucca E., Bertoni F., Roggero F., Cavalli F. The gastric marginal zone B-cell lymphoma of MALT type. Blood. 96: 410 - 419. Cerca con Google

39. Crotta S., Stilla A., Wack A., D’Andrea A., Nuti S., D’Oro U., Mosca M., Filipponi F., Brunetto R. M., Bonino F., Abrignani S., Valiante N. M. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med. 2002; 195: 35 - 41. Cerca con Google

40. Tseng C. T. K., Klimpel G. R. Binding of the hepatitis c virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med. 2001; 195: 43 - 50. Cerca con Google

41. Mondelli M. U., Cerino A., Lisa A., Brambilla S., Segagni L., Cividini A., Bissolati M., Missale G., Bellati G., Meola A., Bruniercole B., Nicosia A., Galfrè G., Silini F. Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated seuqence variation. Hepatology. 1999; 30: 537 - 545. Cerca con Google

42. Chang K. M., rehermann B., McHutchison J. G., Pasquinelli C., South-wood S., Sette A., Chisari F. V. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by hepatitis C virus. J Clin Invest. 1997; 100: 2376 - 2385. Cerca con Google

43. Yao Z. Q., Nguyen D. T., Hiotellis A. I., Hahn Y. S. Hepatitis C virus core protein inhibits human T lymphocytes responses by a complement-dependent regulatory pathway. J Immunol. 2001; 167: 5264 - 5272. Cerca con Google

44. Waggoner S. N., Hall C. H., Hahn Y. S. HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production. J Leuko Biol. 2007; 82: 1407 - 1419. Cerca con Google

45. Ruiz-Irastorza G., Khmamashta A., Castellino G., Hughes G. R. V. Systemic lupus erythematosus. Lancet. 2001; 357: 1027 - 1032. Cerca con Google

46. Porakishvili N., Mageed R., Jamin C., Pers J.-O., Kulikova N., Renaudineau Y., Lydyard P. M., Youinou P. Recent progress in the understanding of B-cell functions in autoimmunity. Scand J Immunol. 2001; 54: 30 - 8. Cerca con Google

47. Renaudineau Y., Pers J. O., bendaoud B., Jamin C., Youinou P. Dysfunctional B cells in systemic lupus erythematosus. Autoimm Rev. 2004; 3: 516 - 523. Cerca con Google

48. Katagiri C., Nakanishi J., Kadoya K., Hibino T. Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase. J Cell Biol. 2006; 172: 983 - 990. Cerca con Google

49. Gettins P. G. W. Keeping the Serpin Machine Running Smoothly. Genome Research. 2000; 10: 1833 - 1835. Cerca con Google

50. Takeda A., Kajiya A., Iwasawa A., Nakamura Y., Hibino T. Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis. Biol Chem. 2002; 383: 1231 - 1236. Cerca con Google

51. Suminami Y., Nagashima S., Murakami A., Nawata S., Gondo T., Hirakawa H., Numa F., Silverman G. A., Kato H. Suppression of a squamous cell carcinoma (SCC)- related serpin, SCC antigen, inhibits tumor growth with increased intratumor infiltration of natural killer cells. Cancer Res. 2001; 61: 1776 – 1780 Cerca con Google

52. Janciauskiene S. Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles. Biochimica et Biophysica Acta. 2001; 1535: 221 - 235. Cerca con Google

53. Kato H., Torigoe T. Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma. Cancer. 1977; 40: 1621 - 1628. Cerca con Google

54. Cataltepe S., Gornstein E. R., Schick C., Kamachi Y., Chatson K., Fries J., Silverman G. A., Upton M. P. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. Histochem Cytochem. 2000 ; 48: 113 - 122. Cerca con Google

55. Senekjian E. K., Young J. M., Weiser P. A., Spencer C. E., Magic S. E., Herbst A. L., An evaluation of squamous cell carcinoma antigen in patients with cervical squamous cell carcinoma. Am J Obst Gin. 1987; 157: 433 - 439. Cerca con Google

56. Esajas M. D., Duk J. M., de Bruijn H. W., Aalders J. G., Willemse P. H., Sluiter W., Pras B., ten Hoor K., Hollema H., van der Zee A. G. Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with early-stage cervical cancer. J Clin Oncol. 2001; 19: 3960 - 3966. Cerca con Google

57. Suminami Y., Nagashima S., Vujanovic N.L., Hirabayashi K., Kato H., Whiteside T.L. Inhibition of apoptosis in human tumor cells by the tumor-associated serpin, SCC antigen-1. Brit J Cancer. 2000; 82: 981 - 989. Cerca con Google

58. De Falco S., Ruvoletto M. G., Verdoliva A., Ruvo M., Raucci A., Marino M., Senatore S., Cassani G., Alberti A., Pontiso P., Fassina G. Cloning and expression of a novel hepatitis B virus binding protein from HepG 2 cells. J. Biol. Chem. 2001; 276: 36613 - 36623. Cerca con Google

59. Pontisso P., Poon M. C., Tiollais P., Brechot C. Detection of hepatitis B virus DNA in mononuclear blood cells. Br Med J 1984; 288: 1563 - 1536. Cerca con Google

60. Pontisso P., Morsica G., Ruvoletto M.G., Zambello R., Colletta C., Chemello L., Alberti A. Hepatitis B virus binds to peripheral blood mononuclear cells via the pre S1 protein. J Hepatol. 1991; 12: 203 - 206. Cerca con Google

61. Uemura Y., Pak S. C., Luke C., Cataltepe S., Tsu C., Schick C., Kamachi Y., Pomeroy S. L., Perlmutter D. H., Silverman G. A. Circulating serpin tumor markers SCCA and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Int. J. Cancer. 2000; 89:368 - 377. Cerca con Google

62. Ruvoletto M. G., N. Tono, D. Carollo, T. Vilei, L. Trentin, M. Muraca, M. Marino, A. Gatta, G. Fassina, P. Pontisso. Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus. J. Gen. Virol. 2004; 85: 621 - 624. Cerca con Google

63. Pontisso P., F. Calabrese, L. Benvegnù, M. Lise, C. Belluco, M. G. Ruvoletto, M. Marino, M. Valente, D. Nitti, A. Gatta, G. Fassina. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. Br. J. Cancer. 2004; 90: 833 - 837. Cerca con Google

64. Beneduce L., Castaldi F., Marino M., Tono N., Gatta A., Pontisso P., Fassina G. Improvement of liver cancer detection with simultaneous assessment of circulating levels of free alpha-fetoprotein (AFP) and AFP-IgM complexes. Int J Biol Markers. 2004; 19: 155 - 159. Cerca con Google

65. Yasumatsu R., T. Nakashima, K. Azuma, N. Hirakawa, Y. Kuratomi, K. Tomita, S. Caltaltepe, G. A. Silverman, G. L. Clayman, S. Komyiama. SCCA1 expression in Tlymphocytes peripheral to cancer cells is associated with the elevation of serum SCC antigen in squamous cell carcinoma of the tongue. Cancer Lett. 2001; 167: 205 - 213. Cerca con Google

66. Molina R., Filella X., Torres M.D., Ballesta A. M., Mengual P., Cases A., Balaque A. SCC antigen measured in malignant and nonmalignant diseases. Clin Chem 1990; 36: 251 - 254. Cerca con Google

67. Takeshima N., Y. Suminami, O. Takeda, H. Abe, N. Okuno, H. Kato. Expression of mRNA of SCC antigen in squamous cells. Tumour Biol. 1992; 13:338 - 342. Cerca con Google

68. Kato H., Suehiro Y., Morioka H., Torigoe T., Myoga A., Sekiguchi K., Ikeda I. Heterogeneous distribution of acidic TA-4 in cervical squamous cell carcinoma: immunohistochemical demonstration with monoclonal antibodies. Jpn J Cancer Res. 1987; 78: 1246 - 1250. Cerca con Google

69. Kato H., Nagaya T., Torigoe T. Eterogeneity of a tumor antigen TA-4 of squamous cell carcinoma in relation to its appearence in the circulation. GANN. 1984; 75: 433 - 435. Cerca con Google

70. Kato H. Expression and function of squamous cell carcinoma antigen. Anticancer Res. 1996; 16: 2149 - 2153. Cerca con Google

71. Kato H. Squamous cell carcinoma antigen Serological Cancer Markers, Humana Press. 1992; 437 - 451. Cerca con Google

72. Hamada K., Shinomiya H., Asano Y., Kihana T., Iwamoto M., Hanakawa Y., Hashimoto K., Hirose S., Kyo S., Ito M. Molecular cloning of human squamous cell carcinoma antigen 1 gen and characterization of its promoter. Biochim et Bioph Acta. 2001; 1518: 124 - 131. Cerca con Google

73. Numa F., Takeda O., Nakata M., Nawata S., Tsugana N., Hirabayashi K., Suminami Y., Kato H., Hamanaka S. Tumor necrosis factor- ? stimulates the production a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad SciUSA. 1995; 92: 3147 - 3151. Cerca con Google

74. Tsuyama S., Hashimoto K., Nakamura K., Tamura H., Sasaki K., Kato H. Different behaviours in the production and release of SCC antigen in squamous-cell carcinoma. Tum Biol. 1991; 12: 28 - 34. Cerca con Google

75. Suminami Y., Kishi F., Sakaguchi K., Kato H. Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. Bioch Bioph Res Commun. 1991; 81: 51 - 58. Cerca con Google

76. Gettins P. G. Serpin structure, mechanism and function. Chem. Rev. 2002; 102: 4751 - 4804. Cerca con Google

77. Kuwano A., Kodo I., Kishi F., Suminami Y., Kato H. Assignment of the squamous cell carcinoma antigen in locus SCCA to 18q21.3 by in situ hybridization. Genomics. 1995; 30: 626. Cerca con Google

78. Silverman G.A., Bartuski A., Cataltepe S., Gornstein E.R., Kamachi Y., Schick C., Uemura Y. SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3. Tum Biol.1998; 19: 480 - 487. Cerca con Google

79. Schneider S.S., Schick C., Fish K.E., Miller J.C., Pena S.D., Treter S.M., Hui G.A., Silverman G.A. A serine proteinase inhibitor locusat 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci USA. 1995; 92: 3147 - 3151. Cerca con Google

80. Suminami Y., Shugo N., Kato H. Biological role of SCC antigen. Tum Biol. 1998; 19: 488 - 493. Cerca con Google

81. Stein P. E., Laslie A. G., Finch J. T., Turnell W. G., McLaghlin P. J., Carrell R. W. Crystal structure of ovoalbumin as a model for reactive centre of serpins. Nature. 1990; 347: 99 - 102. Cerca con Google

82. Schick C., Kamachi Y., Bartuski A. J., Cataltepe S., Schecher N. M., Pemberton P. A., Silverman G. A. Squamous cell carcinoma antigen: a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chynase. Journ Biol Chem. 1997; 272: 1849 -1855. Cerca con Google

83. Schick C., Pemberton P. A., Shi G. P., Kamachi Y., Cataltepe S., Bartuski A. J., Gornstein E. R., Bromme D., Chapman H. A., Silverman G. A. Cross-class inhibition of the cysteine proteinases cathepsin K, L and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry. 1998; 37: 5258 - 5266. Cerca con Google

84. Suchiro Y., Jato H., Nagai M., Torigoe T. Flow citometric analysis of tumor antigen TA-4 in cervical cytologic speciemens. Cancer. 1986; 57: 1380 – 1384 Cerca con Google

85. Duk J. M, Van Voorst Vader P. C., Ten Hoor K. A., Hollema H., Doeglas H. M. G., De Bruijin H. W. A. Elevated levels of squamous cell carcinoma antigen in patients with benign disease of the skin. Cancer. 1989; 64: 1652 - 1656. Cerca con Google

86. Tramonti G., Ferdeghini M., Donadio C., Norpoth M., Annichiarico C., Bianchi R., Bianchi C. Renal function and serum concentration of five tumor markers (TATI, SCC, CYFRA 21-1, TPA, and TPS) in patients without evidence of neoplasia. Cancer Detect Prev. 2000; 24: 86 - 90. Cerca con Google

87. Miret C., Font J., Molina R., Filella X., Vivancos J., Muñoz-Rodriguez F. J., Cervera R., Ballesta A. M., Ingelmo M. Lack of correlation between tumor markers (CA 125 and SCC) and systemic lupus erythematosus activity. Anticancer Res. 1998; 18: 1341 - 1344. Cerca con Google

88. Ni J., E. Hembrador, A. M. Di Bisceglie, I. M. Jacobson, A. H. Talal, D. Butera, C. M. Rice, T. J. Chambers, L. B. Dustin. Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients. J Immunol. 2003; 170: 3429 - 3439. Cerca con Google

89. Renaudineau Y., Pers J. O., Bendaoud B., Jamin C., Youinou P. Dysfunctional B cells in systemic lupus erythematosus. Autoimm Rev. 2004; 3: 516 - 523. Cerca con Google

90. Koike K. Hepatitis C virus contributes to hepatocarcinogenesis by modulating metabolic and intracellular signaling pathways. J Gastroenterol Hepatol. 2007; 22: S108 -11. Cerca con Google

91. Bertoletti A., Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology. 2003; 38: 4 - 13. Cerca con Google

92. Quarta S., L. Vidalino, M. G. Ruvoletto, M. Della Barbera, F. Calabrese, M. Valente, L. Beneduce, A. Gatta, G. Fassina, P. Pontisso. SCCA over-expression induces cell proliferation and down-regulation of the adhesion system. [abstract]. J Clin. Virol. 2006; 36: S193. Cerca con Google

93. Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE); a long term prospective study. Clin Exp Immunol. 1994; 97: 439 - 444. Cerca con Google

94. Xiaofang Y., Yue Z., Xialian X., Zhibin Y. Serum tumour markers in patients with chronic kidney disease. Scand J Clin Lab Invest. 2007; 67: 661 - 667. Cerca con Google

95. Tangye S. G. , Y. J. Liu, G. Aversa, J. H. Phillips, J. E. De Vries. Identification of functional splenic memory B cells by expression of CD148 and CD27. J Exp Med 1998; 188: 1691 - 1703. Cerca con Google

96. Racanelli V., M. A. Frassanito, P. Leone, M. Galiano, V. De Re, F. Silvestris, F. Dammacco. Antibody production and in vitro behaviour of CD27-defined C-cell subsets: persistent hepatitis C virus infection changes the rules. J Virol. 2006; 80: 3923 - 3934. Cerca con Google

97. Ni J., E. Hembrador, A. M. Di Bisceglie, I. M. Jacobson, A. H. Talal, D. Butera, C. M. Rice, T. J. Chambers, L. B. Dustin. Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients. J Immunol. 2003; 170: 3429 - 3439. Cerca con Google

98. Sato S., Fujimoto M., Hasegawa M., Takehara K. Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells. Arthritis Rheum. 2004 50: 1918 - 1927. Cerca con Google

99. Anolik J., Sanz I. B cells in human and murine systemic lupus erythematosus. Curr Opin Rheumatol. 2004; 16: 505 - 512. Cerca con Google

Download statistics

Solo per lo Staff dell Archivio: Modifica questo record