Casalone, Mauro (2011) Correlazione tra la risposta al test da carico del glucosio e l'incidenza di alcune patologie metaboliche nella vacca da latte. [Tesi di dottorato]
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Most of the metabolic diseases of dairy cows occur within the transition period and most periparturient abnormalities have some metabolic element as a component of the sufficient cause of clinical disease. In particular, during the transition period, the glucose requirements are considerably high and lipid metabolism is related to insulin secretion and sensibility. The aim of this study was to evaluate cows response to a field glucose tolerance test (FGTT) in order to identify potential differences in energetic metabolism assessment in early lactation and the incidence of principal postpartum diseases. 78 dairy cows in late dry period (10±5 days from predicted calving) have been submitted to a FGTT that consisted in i.v. injection of 0.5g of glucose per kg of body weight. Glycaemia was measured before the glucose infusion (T0) and at 80 minutes (T80) after the infusion and T80/T0 ratio was calculated in order to subdivide animals into 2 groups: T80/T0<1.05 (group normal), T80/T0>1.05 (group control). A blood sample was collected during early lactation (5-15 days of lactation) and analyzed for the following parameters: NEFA, B-OHB, cholesterol, insulin, glucose, albumin and urea. Data were analyzed by ANOVA to verify the effect of the group using SIGMA STAT 3.05. The results show a statistical significant difference for B-OHB (P<0.05) between group normal (0.43±0.16 mmol/L), group control (1.66±0.13 mmol/L) and NEFA between group normal(0,29±0.05 mEq/L), group control ( 0,44±0.05); incidence of Subclinical Ketosis (P<0.05) between group normal (20%) and group control (57%); and BCS at dry period (P<0.05) between group normal (3.32±0.05), and group control (2.89±0.29). These data suggest that this field GTT could be used to asses metabolic risk of dairy cows to develop postpartum diseases as retained placenta and subclinical ketosis. Further investigations need to confirm these data and to understand the pathogenic factors involved in these correlation.
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Le principali patologie metaboliche si vcerificsno nel periodo di tansizione per un'alterazione del metabolism energetico. Tali patologie sono considerate come deifattori limitanti per una bovina in quanto comprometto la carrier produttiva e riproduttiva della bovina stessa.
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