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Bergonzini, Valeria (2008) Studio dei meccanismi molecolari alla base del coinvolgimento della proteina NEF di HIV-1 nella demenza associata ad HIV-1 (HAD). [Tesi di dottorato]

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Abstract (inglese)

During HIV-1 associated dementia (HAD), a variety of HIV-1-induced lesions of the central nervous system (CNS) has been described, including neuronal loss, but very little is known about the mechanisms that lead to this process.
Among HIV-1 proteins, we analysed the role of Nef since it could alter some signal transduction pathways related to cellular proteins involved in neuronal differentiation, such as ALK (Anaplastic Lymphoma Kinase), thus contributing to explain some of the HAD features. Our data show that Nef alters ALK expression and interferes with the ALK signal transduction pathway, in particular by modifying the MMP-9 (Matrix MetalloProteinase-9) and MMP-2 (Matrix MetalloProteinase-2) pathways. Furthermore, Nef and ALK show a cumulative effect in the modulation of cytochines/chemokines and of proteins involved in their common transduction pathways, such as MAP-K.


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Tipo di EPrint:Tesi di dottorato
Relatore:Palù, Giorgio
Dottorato (corsi e scuole):Ciclo 20 > Corsi per il 20simo ciclo > VIROLOGIA E BIOTECNOLOGIE MICROBICHE
Data di deposito della tesi:31 Gennaio 2008
Anno di Pubblicazione:31 Gennaio 2008
Parole chiave (italiano / inglese):HIV-1, HAD, Nef, ALK, signaling
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Struttura di riferimento:Dipartimenti > Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche
Codice ID:375
Depositato il:24 Set 2008
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