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Bergonzini, Valeria (2008) Studio dei meccanismi molecolari alla base del coinvolgimento della proteina NEF di HIV-1 nella demenza associata ad HIV-1 (HAD). [Ph.D. thesis]

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Abstract (english)

During HIV-1 associated dementia (HAD), a variety of HIV-1-induced lesions of the central nervous system (CNS) has been described, including neuronal loss, but very little is known about the mechanisms that lead to this process.
Among HIV-1 proteins, we analysed the role of Nef since it could alter some signal transduction pathways related to cellular proteins involved in neuronal differentiation, such as ALK (Anaplastic Lymphoma Kinase), thus contributing to explain some of the HAD features. Our data show that Nef alters ALK expression and interferes with the ALK signal transduction pathway, in particular by modifying the MMP-9 (Matrix MetalloProteinase-9) and MMP-2 (Matrix MetalloProteinase-2) pathways. Furthermore, Nef and ALK show a cumulative effect in the modulation of cytochines/chemokines and of proteins involved in their common transduction pathways, such as MAP-K.

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EPrint type:Ph.D. thesis
Tutor:Palù, Giorgio
Ph.D. course:Ciclo 20 > Corsi per il 20simo ciclo > VIROLOGIA E BIOTECNOLOGIE MICROBICHE
Data di deposito della tesi:31 January 2008
Anno di Pubblicazione:31 January 2008
Key Words:HIV-1, HAD, Nef, ALK, signaling
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Struttura di riferimento:Dipartimenti > pre 2012 Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche
Codice ID:375
Depositato il:24 Sep 2008
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