Vai ai contenuti. | Spostati sulla navigazione | Spostati sulla ricerca | Vai al menu | Contatti | Accessibilità

| Crea un account

MIGLIORE, FEDERICO (2013) Arrhythmogenic Right Ventricular Cardiomyopathy:
Prognostic Value of Electroanatomic Voltage Mapping.
[Tesi di dottorato]

Full text disponibile come:

[img]
Anteprima
Documento PDF (Tesi Dottorato Dott. Federico Migliore) - Versione pubblicata
4Mb

Abstract (inglese)

Background: Endocardial voltage mapping (EVM) identifies low-voltage right ventricular (RV) areas, which may represent the electroanatomic scar substrate of life-threatening tachyarrhythmias. We prospectively assessed the prognostic value of EVM in a consecutive series of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC).

Methods: We studied 69 consecutive ARVC patients [47 males; median age 35 years(28-45)] who underwent electrophysiological study and both bipolar and unipolar EVM. The extent of confluent bipolar (<1.5mV) and unipolar (<6.0mV) low-voltage electrograms was estimated using the CARTO-incorporated area calculation software.

Results: Fifty-three patients (77%) showed ≥1 RV electroanatomic scars with an estimated burden of bipolar vs unipolar low-voltage areas of 24.8% (7.2-31.5) and 64.8% (39.8-95.3), respectively (P=0.009). In the remaining patients with normal bipolar-EVM (n=16;23%), the use of unipolar EVM unmasked ≥1 region of low-voltage electrogram affecting 26.2% (11.6-38.2) of RV wall. During a median follow-up of 41 (28-56) months, 19(27.5%) patients experienced arrhythmic events, such as sudden death (n=1), appropriate ICD interventions (n=7), or sustained ventricular tachycardia (n=11). Univariate predictors of arrhythmic outcome included previous cardiac arrest or syncope (HR=3.4; 95%CI:1.4-8.8; P=0.03) and extent of bipolar low-voltage areas (HR=1.7 per 5%; 95%CI=1.5-2; P<0.001), while the only independent predictor was the bipolar low-voltage electrogram burden (HR=1.6 per 5%; 95% CI:1.2-1.9; P<0.001). Patients with normal bipolar-EVM had an uneventful clinical course.

Conclusions: The extent of bipolar RV endocardial low-voltage area was a powerful predictor of arrhythmic outcome in ARVC, independently of history and RV dilatation/dysfunction. A normal bipolar-EVM characterized a low-risk subgroup of ARVC patients.

Abstract (italiano)

Introduzione: Il mappaggio elettroanatomico mediante sistema CARTO permette di identificare e quantificare aree di basso voltaggio del ventricolo destro che corrispondono a cicatrici elettroanatomiche, substrato di aritmie ventricolari pericolose per la vita.
Lo scopo dello studio era di valutare, in modo prospettico, il valore prognostico del mappaggio elettroanatomico in una coorte di pazienti affetti da Cardiomiopatia Aritmogena del Ventricolo Destro.

Materiali e Metodi: La popolazione di studio includeva 69 pazienti (47maschi; età mediana 35 anni; 28-35) affetti da Cardiomiopatia Aritmogena del Ventricolo Destro. Tutti i pazienti sono stati sottoposti ad un completo work up clinico che includeva: elettrocardiogramma, ecocardiografia, cateterismo cardiaco, studio elettrofisiologico e mappaggio elettroanatomico del ventricolo destro, utilizzando sia mappe bipolari sia unipolari. L’estensione degli elettrogrammi confluenti di basso voltaggio bipolari (<1.5 mV) e unipolari (<6.0 mV) è stata stimata usando un software incorporato nel sistema CARTO.

Risultati: In cinquantatre pazienti (77%) è stata riscontrata ≥1 regione cicatriziale a carico del ventricolo destro con una percentuale stimata di aree di basso voltaggio bipolari e unipolari rispettivamente di 24.8% (7.2-31.5) e 64.8 (39.8-95.3), rispettivamente (P=0.009). In tutti pazienti con una normale mappa bipolare (n= 16; 23%) l’utilizzo del mappaggio unipolare ha identificato ≥1 regione con elettrogrammi di basso voltaggio che interessava il 26.2% (11.6-38.2) del ventricolo destro. Durante un follow-up di 41 (28-56) mesi 19 (27.5%) pazienti subirono eventi aritmici maggiori, quali morte improvvisa (n=1), intervento appropriato dell’ICD (n=7), o tachicardia ventricolare sostenuta (n=11). All’analisi univariata i predittori dell’outcome aritmico includevano: sincope (HR=3.4; 95%CI: 1.4-8.8; P=0.03), e l’estensione delle aree di basso voltaggio bipolare (HR=1.7 per 5%; 95%CI: 1.5-2; P<0.001). All’analisi multivariata, l’unico predittore indipendente risultava l’estensione delle aree di basso voltaggio al mappaggio bipolare (HR=1.6 per 5%;95% CI:1.2-1.9; P<0.001). Tutti i pazienti con un mappaggio bipolare normale presentavano un decorso clinico privo di eventi aritmici.

Conclusioni: l’estensione delle aree endocardiche di basso voltaggio nel ventricolo destro risulta essere un potente predittore di eventi aritmici maligni nella Cardiomiopatia Aritmogena del Ventricolo Destro indipendentemente dalla storia clinica e dalla dilatazione/disfunzione del ventricolo destro. La presenza di un normale mappaggio elettroanatomico bipolare rapprestanta un sottogruppo di pazienti affetti da Cardiomiopatia Aritmogena del Ventricolo Destro a basso rischio aritmico.




Statistiche Download - Aggiungi a RefWorks
Tipo di EPrint:Tesi di dottorato
Relatore:CORRADO, DOMENICO
Dottorato (corsi e scuole):Ciclo 25 > Scuole 25 > SCIENZE MEDICHE, CLINICHE E SPERIMENTALI > SCIENZE CARDIOVASCOLARI
Data di deposito della tesi:21 Gennaio 2013
Anno di Pubblicazione:Gennaio 2013
Parole chiave (italiano / inglese):Cardiomiopatia Aritmogena del Ventricolo Destro; Mappaggio Elettroanatomico di Voltaggio; Valore prognostico; Morte Improvvisa; Arrhtrhmogenic Right Ventricular Cardiomyopathy; Electroanatomic Voltage Mapping; Prognostic Value; Sudden Death;
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/11 Malattie dell'apparato cardiovascolare
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari
Codice ID:5381
Depositato il:16 Ott 2013 08:00
Simple Metadata
Full Metadata
EndNote Format

Bibliografia

I riferimenti della bibliografia possono essere cercati con Cerca la citazione di AIRE, copiando il titolo dell'articolo (o del libro) e la rivista (se presente) nei campi appositi di "Cerca la Citazione di AIRE".
Le url contenute in alcuni riferimenti sono raggiungibili cliccando sul link alla fine della citazione (Vai!) e tramite Google (Ricerca con Google). Il risultato dipende dalla formattazione della citazione.

1. Lancisi GM. De motu cordis et aneurysmatibus. Caput V. Naples (Italy); 1736 Cerca con Google

2. Laennec RT. Paris, 1904. In: Laennec SH, editor, Savie, son ouvrage, vol. 13. London: Encyclop. Brit; 1956. p. 586 Cerca con Google

3. Eliot G. Middlemarch. 1st edition. New York, 1871 Cerca con Google

4. Osler W. The principles and practice of medicine. 6th edition. New York: D. Appleton & Co; 1905. p.20 Cerca con Google

5. Segall HN. Parchment heart (Osler). Am Heart J 1950;40:948–50 Cerca con Google

6. UHL HS. A previously undescribed congenital malformation of the heart: almost total absence of the myocardium of the right ventricle. Bull Johns Hopkins Hosp 1952;91:197–209 Cerca con Google

7. Dalla Volta S, Fameli O, Maschio G. Le sindrome clinique et hemodynamique de l’auricularisation du ventricule droit. Arch Mal Coeur Vaiss 1965;58:1129–43 Cerca con Google

8.Thiene G, Nava A, Marcus FI. Introduction: arrhythmogenic right ventricular cardiomyopathy/dysplasia clarified. In: Marcus FI, Nava A, Thiene G, editors. Arrhythmogenic right ventricular cardiomyopathy/dysplasia—recent advances. Milano (Italy): Springer; 2007. p. 1–6 Cerca con Google

9. Thiene G. Storia di una malattia. In: Basso C, Nava A, Thiene G, editors. La cardiomiopatia aritmogena. Milano (Italy): Arti Grafiche Color Black; 2001. p. 1–7 Cerca con Google

10. Fontaine G, Guiraudon G, Frank R, et al. Stimulation studies and epicardial mapping in ventricular tachycardia: study of mechanisms and selection for surgery. In: Kulbertus HE, editor. Reentrant arrhythmias. Lancaster (UK): MTP; 1977. p. 334–50 Cerca con Google

11. Fontaine G, Frank R, Gallais-Hamonno F, et al. Electrocardiographie des potentials tardifs du syndrome de post-excitation. Arch Mal Coeur Vaiss 1978;71:854–9 Cerca con Google

12. Marcus FI, Fontaine G, Guiraudon G, et al. Right ventricular dysplasia. A report of 24 adult cases. Circulation 1982;65:384–98. Cerca con Google

13. Nava A, Scognamiglio R, Thiene G, et al. A polymorphic form of familial arrhythmogenic right ventricular dyplasia. Am J Cardiol 1987;59:1405–9 Cerca con Google

14. Nava A, Thiene G, Canciani B, et al. Familial occurrence of right ventricular dysplasia: a study involving nine families. J Am Coll Cardiol 1988;12:1222–8 Cerca con Google

15. Thiene G, Nava A, Corrado D, et al. Right ventricular cardiomyopathy and sudden death in young people. N Engl J Med 1988;318:129–33 Cerca con Google

16. Maron BJ. Right ventricular cardiomyopathy. Another cause of sudden death in the young [editorial]. N Engl J Med 1988;318:178–9 Cerca con Google

17. Protonotarios N, Tsatsopoulou A, Scampardonis G. Familial arrhythmogenic right ventricular dysplasia associated with palmoplantar keratosis. N Engl J Med 1988;319:174–6 Cerca con Google

18.Corrado D, Thiene G, Nava A, et al. Sudden death in young competitive athletes: clinicopathologic correlation in 22 cases. Am J Med 1990;89:588–96 Cerca con Google

19. McKenna WJ, Thiene G, Nava A, et al. Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Br Heart J 1994;71:215–8 Cerca con Google

20. Marcus FI, McKenna WJ, Sherrill D, et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia. Proposed modification of the Task Force criteria. Circulation 2010;121:1533–41 Cerca con Google

21. Corrado D, Leoni L, Link MS, et al. Implantable cardioverter defibrillator therapy for prevention of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. Circulation 2003;108:3084–91 Cerca con Google

22. Corrado D, Calkins H, Link MS, et al. Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia. Circulation 2010;122:1144–52 Cerca con Google

23. Basso C, Thiene G, Valente M, et al. Arrhythmogenic right ventricular cardiomyopathy: dysplasia, dystrophy or myocarditis? Circulation 1996;94:983–91 Cerca con Google

24. Thiene G, Corrado D, Basso C. Cardiomyopathies: is it time for a molecular classification? Eur Heart J 2004;25:1772–5 Cerca con Google

25. Maron BJ, Towbin JA, Thiene G, et al. American Heart Association; Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; Council on Epidemiology and Prevention. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006;113:1807–16 Cerca con Google

26. Basso C, Corrado D, Marcus FI, Nava A, Thiene G. Arrhythmogenic right ventricular cardiomyopathy. Lancet. 2009;373:1289-1300 Cerca con Google

27. Corrado D, Basso C, Pilichou K, Thiene G. Molecular biology and clinical management of arrhythmogenic right ventricular cardiomyopathy/dysplasia. Heart. 2011;97:530-539 Cerca con Google

28. Bauce B, Basso C, Rampazzo A, et al. Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations. Eur Heart J 2005;26:1666–75 Cerca con Google

29. Sen-Chowdhry S, Syrris P, Ward D, et al. Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression. Circulation 2007;115:1710–20 Cerca con Google

30. Basso C, Czarnowska E, Della Barbera M, et al. Ultrastructural evidence of intercalated disc remodelling in arrhythmogenic right ventricular cardiomyopathy: an electron microscopy investigation on endomyocardial biopsies. Eur Heart J 2006; 27:1847–54 Cerca con Google

31. Sen-Chowdry S, Syrris P, McKenna WJ. Role of genetic analysis in the management of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol 2007;50:1813–21 Cerca con Google

32.Corrado D, Fontaine G, Marcus FI, et al. Arrhythmogenic right ventricular dysplasia/cardiomyopathy: need for an International Registry. Circulation 2000;101:e101–6 Cerca con Google

33. Basso C, Wichter T, Danieli GA, et al. Arrhythmogenic right ventricular cardiomyopathy: clinical registry and database, evaluation of therapies, pathology registry, DNA banking. Eur Heart J 2004;25:531–4 Cerca con Google

34. Marcus F, Towbin JA, Zareba W, et al, ARVD/C Investigators. Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C): a multidisciplinary study: design and protocol. Circulation 2003;107:2975–8 Cerca con Google

35. Corrado D, Basso C, Thiene G, et al. Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multi center study. J Am Coll Cardiol 1997;30:1512–20 Cerca con Google

36. Thiene G, Corrado D, Basso C. Arrhythmogenic right ventricular cardiomyopathy/dysplasia. Orphanet J Rare Dis 2007;2:45 Cerca con Google

37. Thiene G, Corrado D, Nava A, et al. Right ventricular cardiomyopathy: is there evidence of an inflammatory aetiology? Eur Heart J 1991;12:22–5 Cerca con Google

38. Basso C, Thiene G. Adipositas cordis, fatty infiltration of the right ventricle, and arrhythmogenic right ventricular cardiomyopathy. Just a matter of fat? Cardiovasc Pathol 2005;14:37–41 Cerca con Google

39. Marcus F, Basso C, Gear K, et al. Pitfalls in the diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia. Am J Cardiol 2010;105:1036–9 Cerca con Google

40. Angelini A, Basso C, Nava A, et al. Endomyocardial biopsy in arrhythmogenic right ventricular cardiomyopathy. Am Heart J 1996;132:203–6. Cerca con Google

41. Basso C, Ronco F, Marcus F, et al. Quantitative assessment of endomyocardial biopsy in arrhythmogenic right ventricular cardiomyopathy/dysplasia: an in vitro validation of diagnostic criteria. Eur Heart J 2008;29:2760–71 Cerca con Google

42. Nava A, Bauce B, Basso C, et al. Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol 2000;36:2226–33 Cerca con Google

43. McKoy G, Protonotarios N, Crosby A, et al. Identification of a deletion in plakoglobin in arrhythmogenic keratoderma and woolly hair (Naxos disease). Lancet 2000;355:2119–24 Cerca con Google

44. Norgett EE, Hatsell SJ, Carvajal-Huerta L, et al. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Hum Mol Genet 2000;9:2761–6 Cerca con Google

45. Alcalai R, Metzger S, Rosenheck S, et al. A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair. J Am Coll Cardiol 2003;42:319–27 Cerca con Google

46. Rampazzo A, Nava A, Malacrida S, et al. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet 2002;71:1200–6 Cerca con Google

47. Gerull B, Heuser A, Wichter T, et al. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet 2004;36:1162–4 Cerca con Google

48. Pilichou K, Nava A, Basso C, et al. Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy. Circulation 2006;113:1171–9 Cerca con Google

49. Syrris P, Ward D, Evans A, et al. Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2. Am J Hum Genet 2006;79:978–84 Cerca con Google

50. Asimaki A, Syrris P, Wichter T, et al. A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet 2007;81:964–73 Cerca con Google

51. Klauke B, Kossmann S, Gaertner A, et al. De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy. Hum Mol Genet 2010;19:4595–607 Cerca con Google

52. Tiso N, Stephan DA, Nava A, et al. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet 2001;10:189–94 Cerca con Google

53. Beffagna G, Occhi G, Nava A, et al. Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1. Cardiovasc Res 2005;65:366–73 Cerca con Google

54. Merner ND, Hodgkinson KA, Haywood AF, et al. Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene. Am J Hum Genet 2008;82:809–21 Cerca con Google

55. Corrado D, Thiene G. Arrhythmogenic right ventricularcardiomyop athy/dysplasia: clinical impact of molecular genetic studies. Circulation 2006;113:1634–7 Cerca con Google

56. Bauce B, Nava A, Beffagna G, et al. Multiple mutations in desmosomal proteins encoding genes in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Heart Rhythm 2010;7:22–9 Cerca con Google

57. Xu T, Yang Z, Vatta M, et al. Multidisciplinary Study of Right Ventricular Dysplasia Investigators. Compound and digenic heterozygosity contributes to arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol 2010;55:587–97 Cerca con Google

58. Kaplan SR, Gard JJ, Protonotarios N, et al. Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm 2004;1:3–11 Cerca con Google

59. Kaplan SR, Gard JJ, Carvajal-Huerta L, et al. Structural and molecular pathology of the heart in Carvajal syndrome. Cardiovasc Pathol 2004;13:26–32 Cerca con Google

60. Asimaki A, Tandri H, Huang H, et al. A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med 2009;360:1075–84 Cerca con Google

61. Bowles NE, Ni J, Marcus F, et al. The detection of cardiotropic viruses in the myocardium of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol 2002;39:892–5 Cerca con Google

62.CalabreseF, Basso C, CarturanE, et al. Arrhythmogenic right ventricular cardiomyopathy/dysplasia: is there a role for viruses? Cardiovasc Pathol 2006;15:11–7 Cerca con Google

63. Pilichou K, Remme CA, Basso C, et al. Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy. J Exp Med 2009;206:1787–802 Cerca con Google

64. Mallat Z, Tedgui A, Fontaliran F, et al. Evidence of apoptosis in arrhythmogenic right ventricular dysplasia. N Engl J Med 1996;335:1190–6 Cerca con Google

65. Valente M, Calabrese F, Thiene G, et al. In vivo evidence of apoptosis in arrhythmogenic right ventricular cardiomyopathy. Am J Pathol 1998;152:479–84 Cerca con Google

66. Huber O. Structure and function of desmosomal proteins and their role in development and disease. Cell Mol Life Sci 2003;60:1872–90 Cerca con Google

67 Desai BV, Harmon RM, Green KJ. Desmosomes at a glance. J Cell Sci 2009;122:4401–7 Cerca con Google

68.Green KJ, Getsios S, Troyanovsky S, et al. Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol 2010;2:a000125 Cerca con Google

69. Sato PY, Musa H, Coombs W, et al. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res 2009;105:523–6 Cerca con Google

70. Delmar M, McKenna WJ. The cardiac desmosome and arrhythmogenic cardiomyopathies: from gene to disease. Circ Res 2010;107:700–14 Cerca con Google

71. Yang Z, Bowles NE, Scherer SE, et al. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res 2006;99:646–55 Cerca con Google

72. Garcia-Gras E, Lombardi R, Giocondo MJ, et al. Suppression of canonical Wnt/beta-catenin signalling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest 2006;116:2012–21 Cerca con Google

73. Sen-Chowdhry S, Prasad SK, Syrris P, et al. Cardiovascular magnetic resonance in arrhythmogenic right ventricular cardiomyopathy revisited: comparison with task force criteria and genotype. J Am Coll Cardiol 2006;48:2132–40 Cerca con Google

74. Protonotarios N, Tsatsopoulou A. The Naxos disease. In: Nava A, Rossi L, Thiene G, editors. Arrhythmogenic right ventricular dysplasia/cardiomyopathy. Elsevier Science B.V; 1997. p. 454–62 Cerca con Google

75. Fontaine G, Fontaliran F, Frank R. Arrhythmogenic right ventricular cardiomyopathies. Clinical forms and main differential diagnoses. Circulation 1998;97:1532–5 Cerca con Google

76. Fontaine G, Fontaliran F, He´bert JL, et al. Arrhythmogenic right ventricular dysplasia. Annu Rev Med 1999;50:17–35 Cerca con Google

77. Protonotarios N, Tsatsopoulou A, Gatzoulis K. Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease). Card Electrophysiol Rev 2002;6:72–80 Cerca con Google

78. Hulot JS, Jouven X, Empana JP, et al. Natural history and risk stratification of arrhythmogenic right ventricular cardiomyopathy. Circulation 2004;110:1879–84 Cerca con Google

79. Fontaine G, Umemura J, Di Donna P, et al. Duration of QRS complexes in arrhythmogenic right ventricular dysplasia. A new non-invasive diagnostic marker. Ann Cardiol Angeiol (Paris) 1993;42(8):399–405 Cerca con Google

80. Peters S, Trummel M. Diagnosis of arrhythmogenic right ventricular dysplasia-cardiomyopathy: value of standard ECG revisited. Ann Noninvasive Electrocardiol 2003;8:238–45 Cerca con Google

81. Cox MG, Nelen MR, Wilde AA, et al. Activation delay and VT parameters in arrhythmogenic right ventricular dysplasia/cardiomyopathy: towards improvement of diagnostic ECG criteria. J Cardiovasc Electrophysiol 2008;19:775–81 Cerca con Google

82. Tandri H, Saranathan M, Rodriguez R, et al. Noninvasivedetection ofmyocardial fibrosis in arrhythmogenic right ventricular cardiomyopathy using delayedenhancement magnetic resonance imaging. J Am Coll Cardiol 2005;45:98–103 Cerca con Google

83. Bomma C, Rutberg J, Tandri H, et al. Misdiagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Cardiovasc Electrophysiol 2004;15:300–6 Cerca con Google

84. Marra MP, Leoni L, Bauce B et al. Imaging study of ventricular scar in arrhythmogenic right ventricular cardiomyopathy: comparison of 3D standard electroanatomical voltage mapping and contrast-enhanced cardiac magnetic resonance. Circ Arrhythm Electrophysiol. 2012;5:91-100 Cerca con Google

85. Vasaiwala SC, Finn C, Delpriore J, et al. Prospective study of cardiac sarcoid mimicking arrhythmogenic right ventricular dysplasia. J Cardiovasc Electrophysiol 2009;20:473–6 Cerca con Google

86.Marcus FI, Zareba W, Calkins H, et al. Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study. Heart Rhythm 2009;6:984–92 Cerca con Google

87. Corrado D, Basso C, Pavei A, et al. Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA 2006;296:1593–601 Cerca con Google

88. Buja G, Estes NA, Wichter T, et al. Arrhythmogenic right ventricular cardiomyopathy/dysplasia: risk stratification and therapy. Prog Cardiovasc Dis 2008;50:282–93 Cerca con Google

89. Canu G, Atallah G, Claudel JP, et al. Pronostic et e´volution a` long term de la dysplasie arythmoge`ne du ventricule droit. Arch Mal Coeur Vaiss 1993;86:41–8 Cerca con Google

90. Marcus FI, Fontaine GH, Frank R, et al. Long-term followup in patients with arrhythmogenic right ventricular disease. Eur Heart J 1989;10(Suppl D):68–73 Cerca con Google

91. Turrini P, Corrado D, Basso C, et al. Dispersion of ventricular depolarization-repolarization: a non invasive marker for risk stratification in arrhythmogenic right ventricular cardiomyopathy. Circulation 2001;103:3075–80 Cerca con Google

92. Corrado D, Basso C, Rizzoli G, et al. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 2003;42:1959–63 Cerca con Google

93. Kirchhof P, Fabritz L, Zwiener M, et al. Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation 2006;114:1799–806 Cerca con Google

94. Turrini P, AngeliniA, ThieneG, et al. Late potentials and ventricular arrhythmias in arrhythmogenicright ventricular cardiomyopathy. Am J Cardiol 1999;83:1214–9 Cerca con Google

95. Wichter T, Paul M, Wollmann C, et al. Implantable cardioverter/defibrillator therapy in arrhythmogenic right ventricular cardiomyopathy: single-center experience of long-term follow-up and complications in 60 patients. Circulation 2004;109:1503–8 Cerca con Google

96. Leclercq JF, Potenza S, Maison-Blanche P, et al. Determinants of spontaneous occurrence of sustained monomorphic ventricular tachycardia in right ventricular dysplasia. J Am Coll Cardiol 1996;28:720–4 Cerca con Google

97. Marchlinski FE, Callans DJ, Gottlieb CD, et al. Linear ablation lesions for control of unmappable ventricular tachycardia in patients with ischemic and nonischemic cardiomyopathy. Circulation 2000;101:1288–96 Cerca con Google

98. Marchlinski FE, Zado E, Dixit S, et al. Electroanatomic substrate and outcome of catheter ablative therapy for ventricular tachycardia in setting of right ventricular cardiomyopathy. Circulation 2004;110:2293–8 Cerca con Google

99. Miljoen H, State S, de Chillou C, et al. Electroanatomic mapping characteristics of ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. Europace 2005;7(6):516–24 Cerca con Google

100. Verma A, Kilicaslan F, Schweikert RA, et al. Shortand long-term success of substrate-based mapping and ablation of ventricular tachycardia in arrhythmogenic right ventricular dysplasia. Circulation 2005;111:3209–16 Cerca con Google

101. Satomi K, Kurita T, Suyama K, et al. Catheter ablation of stable and unstable ventricular tachycardias in patients with arrhythmogenic right ventricular dysplasia. J Cardiovasc Electrophysiol 2006;17:469–76 Cerca con Google

102. Garcia FC, Bazan V, Zado ES, et al. Epicardial substrate and outcome with epicardial ablation of ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Circulation 2009;120:366–75 Cerca con Google

103. Polin G, Hutchinson MD, Garcia FC, et al. Endocardial unipolar voltage mapping more accurately predicts epicardial scar than endocardial bipolar mapping in an ARVD population. Heart Rhythm 2009;6:S118 Cerca con Google

104. Riley MP, Zado ES, Hutchinson MD, et al. Lack of uniform progression of endocardial scar in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy and ventricular tachycardia. Heart Rhythm 2008;5:S74 Cerca con Google

105. Wichter T, Borggrefe M, Haverkamp W, et al. Efficacy of antiarrhythmic drugs in patients with arrhythmogenic right ventricular disease. Results in patients with inducible and noninducible ventricular tachycardia. Circulation 1992;86:29–37 Cerca con Google

106. Wichter T, Paul TM, Eckardt L, et al. Arrhythmogenic right ventricular cardiomyopathy. Antiarrhythmic drugs, catheter ablation, or ICD? Herz 2005;30:91–101 Cerca con Google

107. Marcus GM, Glidden DV, Polonsky B, et al. Efficacy of antiarrhythmic drugs in arrhythmogenic right ventricular cardiomyopathy: a report from the North American ARVC Registry. J Am Coll Cardiol 2009;54:609–15 Cerca con Google

108. Corrado D, Basso C, Thiene G. Sudden death in young athletes. Lancet 2005;366 (Suppl 1):S47–8 Cerca con Google

109. Maron BJ. Sudden death in young athletes. N Engl J Med 2003;349:1064–75 Cerca con Google

110. Corrado D, Basso C, Schiavon M, et al. Screening for hypertrophic cardiomyopathy in young athletes. N Engl J Med 1998;339:364–9 Cerca con Google

111. Corrado D, Basso C, Rizzoli G, et al. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 2003;42:1959–63 Cerca con Google

112. Corrado D, Migliore F, Bevilacqua M et al. Sudden cardiac death in Athletes. Can it be prevented by screening? Herz 2009;34:259-66 Cerca con Google

113. Corrado D, Basso C, Schiavon M, et al. Pre-participation screening of young competitive athletes for prevention of sudden cardiac death. J Am Coll Cardiol 2008;52:1981–9 Cerca con Google

114. Van Camp SP, Bloor CM, Mueller FO, et al. Non-traumatic sports death in high school and college athletes. Med Sci Sports Exerc 1995;27:641–7 Cerca con Google

115. Maron BJ, Gohman TE, Aeppli D. Prevalence of sudden cardiac death during competitive sports activities in Minnesota high school athletes. J Am Coll Cardiol 1998;32:1881–4 Cerca con Google

116. Corrado D, Migliore F, Basso C, et al. Exercise and the risk of sudden cardiac death. Herz 2006;31:553–8 Cerca con Google

117. Corrado D, Basso C, Pelliccia A, et al. Sports and heart disease. In: Camm J, Luscher TF, Serruys PW, editors. The ESC textbook of cardiovascular medicine. New York: Oxford University Press; 2009. p.1215–37 Cerca con Google

118. Corrado D, Pelliccia A, Bjornstad HH, et al. Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death:proposal for a common European protocol. Consensus Statement of the Study Group of Sport Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J 2005;26:516–24 Cerca con Google

119. Pelliccia A, Di Paolo FM, Quattrini FM et al. Outcomes in atlete with marked ECG repolarization abnormalities. N Engl J Med. 2008;358:152–161 Cerca con Google

120. Pelliccia A, Maron BJ, Culasso F et al. Clinical significance of abnormal electrocardiographic patterns in trained athletes. Circulation. 2000;102:278 –284 Cerca con Google

121. Pelliccia A, Culasso F, Di Paolo FM et al. Prevalence of abnormal electrocardiograms in a large, unselected population undergoing pre-participation cardiovascular screening. Eur Heart J. 2007;28:2006 –2010 Cerca con Google

122. Papadakis M, Basavarajaiah S, Rawlins J et al. Prevalence and significance of T-wave inversions in predominantly Caucasian adolescent athletes. Eur Heart J. 2009;30:1728–1735. Cerca con Google

123. Corrado D, Pelliccia A, Heidbuchel H et al. Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J. 2010;31:243–259 Cerca con Google

124. Migliore F, Zorzi A, Michieli P et al. Prevalence of cardiomyopathy in Italian asymptomatic children with electrocardiographic T-wave inversion at preparticipation screening. Circulation. 2012;125(3):529-38 Cerca con Google

125. Klein H, Karp RB, Kouchousus NT et al. (Intraoperative electrophysiologic mapping of the ventricles during sinus rhythm in patients with a previous myocardial infarction. Identification of the electrophysiologic substrate of ventricular arrhythmia. Circulation; 1982;66:847-854 Cerca con Google

126. Cassidy DM, Vassallo JA, Miller JM, et al. Endocardial catheter mapping in patients in sinus rhythm: relationship to underlying heart disease and ventricular arrhythmias. Circulation 1986;73:645–52 Cerca con Google

127. Gepstein L, Goldin A, Lessick J, et al. Electromechanical characterization of chronic myocardial infarction in the canine coronary occlusion model. Circulation;1998:2055–64 Cerca con Google

128. Kornowski R, Hong MK, Gepstein L, et al.. Preliminary animal and clinical experiences using an electromechanical endocardial mapping procedure to distinguish infarcted from healthy myocardium. Circulation; 1998;98:1116–24 Cerca con Google

129. Smeets JLRM, Ben-Haim SA, Rodriguez LM, et al. New method for nonfluoroscopic endocardial mapping in humans : accuracy assessment and first clinical results. Circulation 1998;97:2426-2432 Cerca con Google

130. Callans DJ, Ren JF, Michele J, et al. Electroanatomic left ventricular mapping in the porcine model of healed anterior myocardial infarction: correlation with intracardiac echocardiography and pathological analysis. Circulation 199;100:1744–50 Cerca con Google

131. Boulos M, Lashevsky I, Reisner S, et al. Electroanatomical mapping of arrhythmogenic right ventricular dysplasia. J Am Coll Cardiol 2001;38:2020-7. Cerca con Google

132.Corrado D, Basso C, Leoni L, et al. Three-dimensional electroanatomic voltage mapping increases accuracy of diagnosing arrhythmogenic right ventricular cardiomyopathy/dysplasia. Circulation 2005;111:3042-50 Cerca con Google

133. Corrado D, Basso C, Leoni L, et al. Three-dimensional electroanatomical voltage mapping and histologic evaluation of myocardial substrate in right ventricular outflow tract tachycardia. J Am Coll Cardiol. 2008;51:731-739 Cerca con Google

134. Fontaine G, Frank R, Tonet JL et al. Arrhythmogenic right ventricular dysplasia: a clinical model for the study of chronic ventricular tachycardia. Jpn Circ J. 1984;4:515-538 Cerca con Google

135. Ellison KE, Friedman PL, Ganz LI, Stevenson WG. Entrainment mapping and radiofrequency catheter ablation of ventricular tachycardia in right ventricular dysplasia. J Am Coll Cardiol 1998;32:724–728 Cerca con Google

136. Hutchinson MD, Gerstenfeld EP, Desjardins B et al. Endocardial unipolar voltage mapping to detect epicardial ventricular tachycardia substrate in patients with nonischemic left ventricular cardiomyopathy. Circ Arrhythm Electrophysiol 2011;4:49-55 Cerca con Google

137. Bhonsale A, James CA, Tichnell C, Murray B et al. Incidence and predictors of implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergoing implantable cardioverter-defibrillator implantation for primary prevention. J Am Coll Cardiol 2011;58:1485-1496 Cerca con Google

138. Santangeli P, Dello Russo A, Pieroni M, Casella M, Di Biase L, Burkhardt JD, Sanchez J, Lakkireddy D, Carbucicchio C, Zucchetti M, Pelargonio G, Themistoclakis S, Camporeale A, Rossillo A, Beheiry S, Hongo R, Bellocci F, Tondo C, Natale A. Fragmented and delayed electrograms within fibrofatty scar predict arrhythmic events in arrhythmogenic right ventricular cardiomyopathy: Results from a prospective risk stratification study. Heart Rhythm. 2012;9:1200-6 Cerca con Google

Download statistics

Solo per lo Staff dell Archivio: Modifica questo record