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Scarpa, Carlotta (2013) The immunological response to breast implant: the role of cells and cytokines in the periprosthetic capsule and their involvement in the onset of the autoimmune diseases. [Ph.D. thesis]

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Abstract (english)

Since their discovery breast prostheses have been criticized for being responsible for triggering systemic autoimmune disease. The presence of breast implants causes a natural foreign body reaction characterized by the infiltration of macrophages and T-cells. In order to understand which immunological pathways could be responsible for giving rise to, and the development of, connective tissue disease such as systemic sclerosis, I considered the cells and cytokines involved, focusing on the relationship between tissue growth factor-β, interleukin (IL)-1, IL-6 and T helper 17 and/or T regulatory cells, and their effects on the different steps of capsular tissue formation. A disturbance in the modulation of these key cytokines may be responsible, in susceptible individuals, for a perpetuation of the inflammatory reaction which can locally lead to capsular contracture and at the systemic level may contribute to triggering autoimmune diseases

Abstract (italian)

Sin dalla loro creazione le protesi mammarie sono state considerate responsabili della possibile insorgenza di malattie autoimmuni sistemiche. La presenza di protesi mammarie provoca una reazione naturale da corpo estraneo caratterizzata dall’infiltrazione di macrofagi e linfociti T. Al fine di capire i meccanismi immunologici che stanno alla base dell’insorgenza e dello sviluppo di malattie, come la sclerodermia, ho considerato le cellule e le citochine coinvolte, focalizzando l’attenzione sulla relazione tra il TGF-β, l’interleuchina (IL)-1, IL-6, i T helper 17 e/o le cellule T regolatrici, e il loro effetto sulle diverse fasi di formazione del tessuto capsulare. Un disturbo nella modulazione di queste citochine chiave può essere responsabile, in soggetti sensibili, di una cronicizzazione della reazione infiammatoria, che può localmente portare a contrattura capsulare e a livello sistemico può contribuire a innescare malattie autoimmuni

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EPrint type:Ph.D. thesis
Tutor:Vindigni, Vincenzo
Ph.D. course:Ciclo 25 > Scuole 25 > BIOLOGIA E MEDICINA DELLA RIGENERAZIONE > INGEGNERIA DEI TESSUTI E DEI TRAPIANTI
Data di deposito della tesi:21 January 2013
Anno di Pubblicazione:17 January 2013
Key Words:capsula periprotesica/breast capsule; Linfociti Th17/Th17 Lymphocyte; malattie autoimmuni/connective tissue disease
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/19 Chirurgia plastica
Struttura di riferimento:Dipartimenti > Dipartimento di Scienze del Farmaco
Codice ID:5399
Depositato il:11 Oct 2013 13:19
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