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Crabu, Stefano (2014) Dalla molecola al paziente: la ricerca oncologica fra laboratori scientifici e spazi clinici. [Tesi di dottorato]

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Abstract (inglese)

BACKGROUND
This PhD dissertation looks at ways to “translate” knowledge and techniques of molecular oncology into novel clinical applications. Using translational research in the field of molecular oncology as a case study, my investigation examines the social interaction between activities in medicine and in research and development and between medical staff and scientists. From a theoretical point of view, my reflection about translational research contrasts with the pipeline representations that social theorists have often adopted, where the trajectory of the translational imperative is shown as both linear and progressive. In this text, I analyse and describe the character of translational research in biomedicine as a new style of practice. This concept points to the complex and heterogeneous set of places and interactions that make up translational research in the molecular oncology domain and the subsequent shaping of new technologies of life and clinical objects, such as new molecular diagnostic tests. My work highlights the fact that translational biomedicine is a complex socio-technical area where research in molecular oncology is performed through heterogeneous practices and various actors are engaged in the construction of new clinical technologies and objects, regulations and cures for disease. The observations I have made over the past year, through ethnographic research in two different settings, have led me to recognize translational research as a complex mixture of the mutual interaction between different disciplines, practices, technologies and forward-looking statements about the future of medicine.
AIMS AND OBJECTIVES
The main goal of this dissertation is to contribute to the respective sociological literature about medicine, science and society by providing an alternative and empirically based understanding of translational biomedicine in action. In order to do this, I provide descriptive ethnographic material through observing both clinical and research activities in molecular oncology. I then explore the ways in which scientists relate to the clinical practices governing their fields and examine how different actors and practitioners handle communication between scientific laboratories and clinical spaces.
RESEARCH METHODS
This study draws on empirical data gathered through ethnographic observation in laboratories and clinical trials, and through documentary analysis and interviews with scientists, clinicians, those who coordinate experiments and data managers

Abstract (italiano)

PREMESSA
Nel corso di questa tesi di dottorato ho rivolto l’attenzione ai processi attraverso i quali le conoscenze biomediche in oncologia molecolare vengono tradotte in nuove applicazioni cliniche. Più precisamente, mi sono focalizzato sulla cosiddetta ricerca traslazionale nel campo dell'oncologia molecolare al fine di indagare le relazioni tra la ricerca scientifica e la medicina, e tra il personale clinico e i ricercatori.
Da un punto di vista teorico, la mia riflessione sulla ricerca traslazionale traccia una discontinuità rispetto ai modelli adottati dalle scienze sociali per studiare i rapporti fra scienza, medicina e società, in cui la traiettoria traslazionale di innovazione è stata tradizionalmente concepita come un meccanismo lineare e progressivo. Nel condurre la ricerca ho adottato una prospettiva maturata dal dialogo fra la sociologia della medicina e della salute e gli studi sociali sulla scienza e la tecnologia, che mi ha permesso di costruire una rete di concetti capaci di cogliere le dinamiche che portano comunità biomediche differenti a convergere e dialogare fra loro. Più in particolare, questa prospettiva mi ha consentito di indagare la ricorsività fra le aspettative, le visioni scientifiche, gli oggetti tecnologici e le pratiche tecnoscientifiche attraverso le quali medici e ricercatori cercano di consolidare e materializzare le narrazioni scientifiche sui “futuri clinici” improntati al nuovo paradigma traslazionale. Da questo punto di vista, l'intersezione fra la clinica e il laboratorio definisce e circoscrive uno spazio bioclinico ibrido, rappresentato dalla ricerca traslazionale. Quest'ultima è stata considerata nei termini di un nuovo stile di pratiche, ovvero come l'esito emergente di un lavoro scientifico che ha stimolato il dialogo e la convergenza fra attori umani e dispositivi tecnologici, risorse linguistiche e pratiche discorsive al fine di comprendere in che modo le aspettative e le aspirazioni su possibili futuri clinici possono essere manipolate e gestite entro i contesti laboratoriali dove conoscenza biomedica e nuove indicazioni terapeutiche vengono prodotte e condivise.
OBIETTIVI DELLA RICERCA
In primo luogo, lo scopo di questa tesi è di contribuire in modo innovativo alla comprensione dei processi di innovazione nella biomedicina contemporanea, cercando di mettere in dialogo diverse prospettive teoriche maturate in seno alla sociologia della medicina e agli studi sociali sulla scienza e la tecnologia. In secondo luogo, nel corso della tesi vengono esplorati in profondità i modi in cui gli scienziati si relazionano alle pratiche e ai problemi clinici che disciplinano il loro campo d'azione, esaminando così in che modo i diversi attori presenti sulla scena della biomedicina traslazionale costruiscono il dialogo tra laboratori scientifici e gli spazi della cura.
METODOLOGIA
Il disegno dell'indagine, costruito in relazione al quadro teorico e agli obiettivi della ricerca, ha previsto l'analisi documentale e l'osservazione etnografica – della durata complessiva di un anno – condotta all'interno dei laboratori e degli spazi clinici localizzati in due differenti setting biomedici del Nord Italia, nei quali la ricerca e la cura oncologica sono gestite secondo un approccio traslazionale. Inoltre sono state realizzate ventitré interviste etnografiche con scienziati, medici, coordinatori di sperimentazione clinica e infermieri impegnati nei diversi contesti empirici presi in considerazione.

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Tipo di EPrint:Tesi di dottorato
Relatore:Neresini, Federico
Dottorato (corsi e scuole):Ciclo 26 > Scuole 26 > SCIENZE SOCIALI: INTERAZIONI, COMUNICAZIONE, COSTRUZIONI CULTURALI
Data di deposito della tesi:26 Gennaio 2014
Anno di Pubblicazione:26 Gennaio 2014
Parole chiave (italiano / inglese):ricerca traslazionale, studi sociali sulla scienza, biomedicina, etnografia / translational research, science and technology studies, biomedicine, etnography
Settori scientifico-disciplinari MIUR:Area 14 - Scienze politiche e sociali > SPS/08 Sociologia dei processi culturali e comunicativi
Area 14 - Scienze politiche e sociali > SPS/07 Sociologia generale
Struttura di riferimento:Dipartimenti > Dipartimento di Filosofia, Sociologia, Pedagogia e Psicologia Applicata
Codice ID:6369
Depositato il:31 Ott 2014 13:35
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