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Matkovic, Urska (2008) Construction of Adenoviral vectors for cancer gene therapy and evaluation of toxic effects of adenoviral infection on Adrenocortical cells. [Tesi di dottorato]

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Abstract (inglese)

Aims of the work were construction and evaluation of recombinant adenoviral vectors for gene therapy of esophageal, hepatocellular and adrenocortical carcinomas in vitro and in vivo. Since adenoviruses have tropism for adrenal gland, human adrenocortical cells were used to assess the toxicity of replication competent adenovirus type 5 and replication incompetent adenoviral vectors. In this regard, the effects of adenoviral infection on adrenocortical gene expression, cell proliferation, cell cycle, cell death and steroidogenesis were investigated.


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Tipo di EPrint:Tesi di dottorato
Relatore:Palù, Giorgio
Correlatore:Barzon, Luisa
Dottorato (corsi e scuole):Ciclo 20 > Corsi per il 20simo ciclo > VIROLOGIA E BIOTECNOLOGIE MICROBICHE
Data di deposito della tesi:31 Gennaio 2008
Anno di Pubblicazione:31 Gennaio 2008
Parole chiave (italiano / inglese):adenoviral vectors, adenovirus, cancer gene therapy, adrenal gland, steroidogenesis
Settori scientifico-disciplinari MIUR:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Struttura di riferimento:Dipartimenti > pre 2012 Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche
Codice ID:678
Depositato il:24 Set 2008
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