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Forgione, Margherita (2015) Neuromodulation by transcranial direct current stimulation: investigation on reading processes. [Tesi di dottorato]

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Abstract (inglese)

Reading is a human skill, fundamental for everyday life, in which a lot of information is given in written form. To explain this process, several theories were advanced: currently there is common agreement on the simultaneous activation of two ways of reading, the direct or lessical one for words, and the phonological one for non-words or novel words. Neuroimaging studies converge in identifying three basic systems for reading, mostly in the left hemisphere: among these, the temporoparietal cortex (TPc) seems to be involved in grapheme to phoneme conversion (phonological route). The aim of the present work is to investigate, through transcranial direct current stimulation (tDCS), the role of TPc in words and non words reading. We also want to investigate different parameters of stimulation. Results of first study suggest bilateral TPc role in reading, and a facilitatory effect of left cathodal-right anodal stimulation on reading onset times. The second study suggest that reference electrode can lead to different effects depending on its position, and that unilateral montage is not as effective as bilateral one, not involving both TPc. The third study suggest that 10 minutes of tDCS are not enough to achieve a modulation, but confirm the role of TPc. The last study with below average readers, suggest that activation state of the stimulated area and difficulty of the task have to be considered too. This work contributes to the study of neural bases of reading and on the functioning of transcranial direct current stimulation on cognitive functions.

Abstract (italiano)

La lettura è una competenza umana, fondamentale per la vita di tutti i giorni, in cui molte informazioni sono fornite in forma scritta. Nel tentativo di spiegare questo processo, diverse teorie sono state avanzate: attualmente vi è comune accordo sull’attivazione simultanea di due vie di lettura, quella diretta o lessicale, per la lettura di parole, e quella fonologica per le parole nuove o le non parole. Gli studi di neuroimaging convergono nell'identificare tre sistemi di base per la lettura, per lo più nell'emisfero di sinistra: tra queste, la corteccia temporo-parietale (TPC) sembra essere coinvolta nella conversione da grafema a fonema (via fonologica). Lo scopo del presente lavoro è quello di indagare, attraverso la stimolazione transcranica a corrente continua (tDCS), il ruolo di TPc nella lettura di parole e non parole. Contemporaneamente vogliamo indagare il ruolo dei diversi parametri di stimolazione. I risultati del primo studio suggeriscono un ruolo di TPc bilaterale nella lettura, ed evidenziano un effetto facilitatorio di sui tempi di risposta vocale con stimolazione catodica sinistra-anodica destra. Il secondo studio suggerisce che l’elettrodo di riferimento può portare ad effetti diversi a seconda della sua posizione, e che il montaggio unilaterale non è efficace come quello bilaterale, coinvolgendo solo la TPc sinistra. Il terzo studio mostra che 10 minuti di tDCS non sono sufficienti per una modulazione efficace, ma conferma il ruolo di TPc. L'ultimo studio è sui lettori con una prestazione di lettura inferiore alla media, ed evidenzia l’importanza dello stato di attivazione dell’area stimolata e della difficoltà del compito. Questo lavoro contribuisce allo studio delle basi neurali del processo di lettura e del funzionamento della stimolazione transcranica a corrente continua sulle funzioni cognitive.

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Tipo di EPrint:Tesi di dottorato
Relatore:Mapelli, Daniela
Dottorato (corsi e scuole):Ciclo 27 > scuole 27 > SCIENZE PSICOLOGICHE
Data di deposito della tesi:02 Febbraio 2015
Anno di Pubblicazione:02 Febbraio 2015
Parole chiave (italiano / inglese):tDCS, reading, words, non-words, temporoparietal cortex, bilateral, duration
Settori scientifico-disciplinari MIUR:Area 11 - Scienze storiche, filosofiche, pedagogiche e psicologiche > M-PSI/02 Psicobiologia e psicologia fisiologica
Area 11 - Scienze storiche, filosofiche, pedagogiche e psicologiche > M-PSI/01 Psicologia generale
Struttura di riferimento:Dipartimenti > Dipartimento di Psicologia Generale
Codice ID:8001
Depositato il:12 Nov 2015 09:47
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Accornero, N., Li Voti, P., La Riccia, M., and Gregori, B. (2006). Visual evoked potentials modulation during direct cortical polarization. Experimental Brain Research, 178 (2), 261-266. Cerca con Google

Amadi, U., Ilie, A., Johansen-Berg, H., and Stagg, C. J. (2014). Polarity-specific effects of motor transcranial direct current stimulation on fMRI resting state networks. Neuroimage, 88(100), 155–161. Cerca con Google

Antal A., Nitsche M.A., Kruse W., Kincses T.Z., Hoffmann K.P., and Paulus W. (2004). Direct current stimulation over V5 enhances visuomotor coordination by improving motion perception in humans. Journal of Cognitive Neuroscience, 16:521–527. Cerca con Google

Antal, A., Terney, D., Poreisz C., and Paulus W., (2007). Towards unravelling task-related modulations of neuroplastic changes induced in the human motor cortex. European Journal of Neuroscience, 26, 2687–2691. Cerca con Google

Batsikadze, G., Paulus, W., Kuo, M., and Nitsche, M.A. (2013). Effect of Serotonin on Paired Associative Stimulation-Induced Plasticity in the Human Motor Cortex. Neuropsychopharmacology, 38, 2260–2267. Cerca con Google

Beaulieu,C., Plewes,C., Paulson, L.A., Roy, D., Snook, L., Concha, L., and Phillips L., (2005) Imaging brain connectivity in children with diverse reading ability. NeuroImage, 25 , 1266– 1271. Cerca con Google

Bikson, M., Datta, A., and Elwassif, M., (2009). Establishing safety limits for transcranial direct current stimulation. Clinical Neurophysiology, 120, 1033–1034. Cerca con Google

Bikson, M., Inoue, M., Akiyama, H., Deans, J. K., Fox, J. E., Miyakawa, H. and Jefferys, J. G. R. (2004). Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro. The Journal of Physiology, 557: 175–190. Cerca con Google

Caramazza, A., and Hillis, A.E. (1990). Where do semantic errors come from? Cortex, 26 (1), 95-122. Cerca con Google

Catani, M., Jones, D. K. and Fytche, D. H. (2005), Perisylvian language networks of the human brain. Ann Neurol., 57: 8–16. Cerca con Google

Cattaneo, Z., Pisoni, A., and Papagno, C., (2011). Transcranial direct current stimulation over Broca’s region improves phonemic and semantic fluency in helathy individuals. Neuroscience, 183, 64–70. Cerca con Google

Creutzfeldt, O.D., Fromm, G.H., and Kapp, H. (1962). Influence of transcortical d-d currents on cortical neuronal activity. Experimental Neurology, 5 (6), 436-452. Cerca con Google

De Aguiar, V., Paolazzi C.L., and Miceli G., (2015). tDCS in post-stroke aphasia: The role of stimulation parameters, behavioral treatment and patient characteristics. Cortex, 63, 296-316. Cerca con Google

Datta, A., Baker, J.M., Bikson, M., and Fridriksson, J., (2011). Individualized model predicts brain current flow during transcranial direct-current stimulation treatment in responsive stroke patient. Brain Stimulation, 4 (3), 169-174. Cerca con Google

Dehaene-Lambertz, G., Dehaene,S., and Hertz-Pannier, L., (2002). Functional Neuroimaging of Speech Perception in Infants. Science, 298, 2013-2015. Cerca con Google

Fertonani, A., Brambilla, M., Cotelli, M., and Miniussi, C. (2014). The timing of cognitive plasticity in physiological aging: a tDCS study of naming. Frontiers in Aging Neuroscience, 6, 131. Cerca con Google

Fertonani, A., Rosini, S., Cotelli, M., Rossini, P.M., and Miniussi. C. (2010). Naming facilitation induced by transcranial direct current stimulation. Behavioural Brain Research, 208 (2), 311-318. Cerca con Google

Filmer, H. L., Dux, P., and Mattingley J. B., (2014) Applications of transcranial direct current stimulation for understanding brain function. Trends in Neurosciences, 37 (12), 742-753. Cerca con Google

Fiori, V., Coccia, M., Marinelli, C.V., Vecchi, V., Bonifazi, S., Ceravolo, M.G.., Provinciali, L., Tomaiuolo, F., and Marangolo, P. (2011). Transcranial Direct Current Stimulation improves word retrieval in healthy and nonfluent aphasic subjects. Journal of Cognitive Neuroscience, 23 (9), 2309-2323. Cerca con Google

Floel, A. (2014). tDCS-enhanced motor and cognitive function in neurological diseases Cerca con Google

Neuroimage, 85 (3), 934-947. Cerca con Google

Flöel, A., Rösser, N., Michka, O., Knecht, S., and Breitenstein, C., (2008). Noninvasive Brain Stimulation Improves Language Learning. Journal of Cognitive Neuroscience, 20 (8),1415,1422. Cerca con Google

Fox, M. D., Corbetta, M., Snyder, A. Z., Vincent, J. L., & Raichle, M. E. (2006). Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proceedings of the National Academy of Sciences of the United States of America, 103(26), 10046–10051. Cerca con Google

Gandiga, P.C., Hummel F.C., and Cohen L.G., (2006). Transcranial DC stimulation (tDCS): A tool for double-blind sham-controlled clinical studies in brain stimulation. Clinical Neurophysiology, 117, 845–850. Cerca con Google

Hoeft, F., Hernandez, A., McMillon, G., Taylor-Hill, H., Martindale, J.L., Meyler, A., Keller, T.A., Siok,W. T., Deutsch, G.K., Just, M.- A., Whitfield-Gabrieli, and S., Gabrieli J.D.A., (2006). Neural Basis of Dyslexia: A Comparison between Dyslexic and Nondyslexic Children Equated for Reading Ability. The Journal of Neuroscience, 26(42), 10700-10708. Cerca con Google

Iuculano, T., and Kadosh, R.C. (2013). The Mental Cost of Cognitive Enhancement. The Journal of Neuroscience, 33(10), 4482-4486. Cerca con Google

Iyer, M. B., Mattu, U., Grafman, J., Lomarev, M., Sato, S., and Wassermann, E. M.(2005). Safety and cognitive effect of frontal DC brain polarization in healthy individuals. Neurology, 64 (5), 872-875. Cerca con Google

Jacobson, L., Koslowsky, M., and Lavidor, M., (2012). tDCS polarity effects in motor and cognitive domains: a meta-analytical review. Experimental Brain Research, 216, 1–10. Cerca con Google

Jobard,G., Crivello,F., and Tzourio-Mazoyer, N., (2003) Evaluation of the dual route theory of reading: a metanalysis of 35 neuroimaging studies. NeuroImage, 20, 693-712. Cerca con Google

Kadosh, R.C., Soskic, S., Iuculano, T., Kanai, R, and Walsh, V. (2010). Modulating neuronal activity procuces specific and long-lasting changes in numerical competence. Current Biology, 22, 2016-2020. Cerca con Google

Kadosh, R. (2013) Using transcranial electrical stimulation to enhance cognitive functions in the typical and atypical brain. Transl. Neurosci. 4, 20–33. Cerca con Google

Klingberg,T., Hedehus, M., Temple, E., Salz, T., Gabrieli, J.D.E., Moseley, M. E., and Poldrack, R.A., (2000). Microstructure of Temporo-Parietal White Matter as a Basis for Reading Ability: Evidence from Diffusion Tensor Magnetic Resonance. Neuron, Vol. 25, 493–500. Cerca con Google

Keeser, D., Padberg, F., Reisinger E., Pogarell O., KirschV., Palm U., Karch S., Möller, H.-J., Nitsche M. A., and Mulert C., (2011). Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: A standardized low resolution. NeuroImage, 55, 644–657. Cerca con Google

Kuo, M-F. and Nitsche, M.A. (2012) Effects of transcranial electrical stimulation on cognition. Clin. EEG Neurosci. 43, 192–199. Cerca con Google

Liebetanz, D., Koch, R., Mayenfels, S., Konig, F., Paulus, W., and Nitsche, M.A. (2009). Safety limits of cathodal transcranial direct current stimulation in rats. Clinical Neuropsychology, 120 (6), 1161-1167. Cerca con Google

Lynn J. Bindman, L.J., Lippold, O.C.J., and Redfearn J. W. T. (1962). The non-selective blocking action of γ-aminobutyric acid on the sensory cerebral cortex of the rat. Journal of Physiology, 162(1), 105–120. Cerca con Google

McCandliss, B.D., Cohen, L., and Dehaene, S. (2003). The visual word form area: expertise for reading in the fusiform gyrus. Trends in cognitive sciences, 7 (7), 293-299. Cerca con Google

Marangolo P., Fiori, V., Di Paola M., Cipollari, S., Razzano C., Oliveri M., and Caltagirone, C., (2013). Differential involvement of the left frontal and temporal regions in verb naming: A tDCS treatment study. Restorative Neurology and Neuroscience, 31, 63–72. Cerca con Google

Meinzer, M., Jahnigen, S., Copland, D.A., Darkow R. Grittner, U., Avirame, K., Rodriguez, A.D., Lindenberg R., and Floel A., (2014). Transcranial direct current stimulation over multiple days improves learning and maintenance of a novel vocabulary. Cortex, 50, 137-147. Cerca con Google

Miniussi, C., and Vallar G., (2011). Brain stimulation and behavioral cognitive rehabilitation: A new tool for neurorehabilitation? Neuropsychological Rehabilitation, 21:5, 553-559. Cerca con Google

Moliadze, V., Antal, A., and Paulus W., (2010). Electrode-distance dependent after-effects of transcranial direct and random noise stimulation with extracephalic reference electrodes. Clinical Neurophysiology, 121, 2165–2171. Cerca con Google

Moos, K., Vossel, S., Weidner, R., Sparing, R., and Fink, G.R. (2012). Modulation of Top-Down control of visual attention by cathodal tDCS over right IPS. The Journal of Neuroscience, 32 (46), 16360-16368. Cerca con Google

Nitsche M.A., and Paulus W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. Journal of Physiology, 527, 633-639. Cerca con Google

Nitsche, M.A., and Paulus, W., (2001). Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology, 57 (10), 1899-1901. Cerca con Google

Nitsche, M.A., Liebetanz, D., Lang, N., Antal, A., Tergau,F., and Paulus, W., Safety criteria for transcranial direct current stimulation (tDCS) in humans. (2003) Clinical Neurophysiology,114, 2220–2222. Cerca con Google

Nitsche, M. A., Seeber, A., Frommann, K., Klein, C. C., Rochford, C., Nitsche, M. S., and Tergau, F. (2005). Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex. The Journal of Physiology, 568(Pt 1), 291–303. Cerca con Google

Nitsche, M.A., Cohen, L.G.,Wassermann, E.M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., and Pascual-Leone, A., (2008). Transcranial direct current stimulation: State of the art 2008. Brain Stimulation, 1, 206–23. Cerca con Google

Oostenvelda, R., and Praamstra, P., (2001). The five percent electrode system for high-resolution E EG and ERP measurements. Clinical Neurophysiology, 112, 712-719. Cerca con Google

Paulesu, E., Danelli, L., and Berlingeri, M. (2014). Reading the dyslexic brain: multiple dysfunctional routes revealed by a new meta-analysis of PET and fMRI activation studies. Frontiers in Human Neuroscience, 8, 1-20. Cerca con Google

Paulus W., (2011). Transcranial electrical stimulation (tES – tDCS; tRNS, tACS) methods. Neuropsychological Rehabilitation: An International Journal, 21(5), 602-617. Cerca con Google

Petersen, S.E., Fox, P.T., Posner, M.I., Mintun, M., and Raichle M.E., (1988). Positron emission tomograghic studies of the cortical anatomy of single-word processing. Nature, 331, 585-590. Cerca con Google

Poreisz, C., Boros, K., Antal, A., and Paulus,W., (2007). Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients. Brain Research Bulletin, 72, 208–214. Cerca con Google

Purpura, D.P., and McMurtry, J.G. (1965). Intracellular activities and evoked potential changes during polarization of motor cortex. Journal of Neurophysiology, 28:1, 166-185. Cerca con Google

Reis, J., Schambra, H.M., Cohen, L.G., Buch, E.R., Fritsch, B., Zarahn, E., Celnik, P.A., and Krakauer, J.W. (2009). Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation. PNAS, 106 (5) 1590-1595. Cerca con Google

Rapp, D., Gerrig, R.J., and Prentice, D. (2001). Readers' Trait-Based Models of Characters in Narrative Comprehension. Journal of Memory and Language, 45 (4), 737-750. Cerca con Google

Ross, L. A., McCoy, D., Coslett, H. B., Olson, I. R., and Wolk, D. A. (2011). Improved Proper Name Recall in Aging after Electrical Stimulation of the Anterior Temporal Lobes. Frontiers in Aging Neuroscience, 3, 16. Cerca con Google

Rosso, C., Valabregue, R., Arbizu, C., Ferrieux, S., Vargas, P., Humbert, F., et al. (2014). Connectivity between right Inferior frontal gyrus and supplementary motor area predicts after-effects of right frontal cathodal tDCS on picture naming speed. Brain stimulation, 7 (1), 12-129. Cerca con Google

Saucedo Marquez, C. M., Zhang, X., Swinnen, S. P., Meesen, R., and Wenderoth, N. (2013). Task-Specific Effect of Transcranial Direct Current Stimulation on Motor Learning. Frontiers in Human Neuroscience, 7, 333. Cerca con Google

Sandrini, M., Fertonani, A., Cohen, L.G., and Miniussi, C. (2012). Double dissociation of working memory load effects induced by bilateral parietal modulation. Neuropsycologia, 50 (3), 396-402. Cerca con Google

Sela, T., Ivry R.B., and Lavidor, M., (2012) Prefrontal control during a semantic decision task that involves idiom comprehension:A transcranial direct current stimulation study. Neuropsychologia, 50, 2271–2280. Cerca con Google

Snowling, M. J. and Hulme, C. (2012), Annual Research Review: The nature and classification of reading disorders – a commentary on proposals for DSM-5. Journal of Child Psychology and Psychiatry, 53: 593–607. Cerca con Google

Sparing, R., Manuel Dafotakis, M., Meister, I. G., Thirugnanasambandam, N., and Fink, G.R., (2008). Enhancing language performance with non-invasive brain stimulation-A transcranial direct current stimulation study in healthy humans. Neuropsychologia, 46, 261–268. Cerca con Google

Stagg, C. J., Wylezinska, M., Matthews, P. M., Johansen-Berg, H., Jezzard, P., Rothwell, J. C., and Bestmann, S. (2009). Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy. Journal of Neurophysiology, 101(6), 2872–2877. Cerca con Google

Stagg CJ, and Nitsche MA (2011) Physiological basis of transcranial direct current stimulation. Neuroscientist, 17,37–53. Cerca con Google

Stagg, C.J. and Johansen-Berg, H. (2013) Studying the effects of transcranial direct-current stimulation in stroke recovery using magnetic resonance imaging. Front. Hum. Neurosci. 7, 857. Cerca con Google

Turkeltaub, P.E., Benson, J., Hamilton, R.H., Datta, A., Bikson, M., and Cosletta, B., (2012). Left lateralizing transcranial direct current stimulation improves reading efficiency. Brain Stimulation, 5, 201–7. Cerca con Google

Zaghi, S., Heine, N., and Fregni, F. (2009). Brain stimulation for the treatment of pain: A review of costs, clinical effects, and mechanisms of treatment for three different central neuromodulatory approaches. Journal of Pain Management, 2(3), 339–352 Cerca con Google

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