Damm-Welk, Christine and Mussolin, Lara and Zimmermann, Martin and Pillon , Marta and Klapper, Wolfram and Oschlies, Ilske and d'Amore, Emanuele S.G. and Reiter, A and Woesmann, Wilhelm and Rosolen, Angelo (2014) Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK-positive anaplastic large-cell lymphoma. [Online journal papers]
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Detection of minimal disseminated disease (MDD) at diagnosis correlates with relapse risk in children with anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphoma (ALCL). We investigated whether minimal residual disease (MRD) positivity by qualitative reverse-transcriptase polymerase chain reaction (RT-PCR) for Nucleophosmin (NPM)-ALK during treatment identifies patients at the highest relapse risk.
Blood and/or bone marrow of 180 patients with NPM-ALK–positive ALCL treated with Berlin-Frankfurt-M ¨ unster-type protocols were screened for NPM-ALK transcripts at diagnosis; 103 were found to be MDD-positive. MRD before the second therapy course could be evaluated in 52 MDD-positive patients. MRD positivity correlated with uncommon histology. The cumulative incidence of relapses (CIR) of 26 MDD-positive/MRD-positive patients (81% 6 8%) was significantly higher than the CIR of 26 MDD-positive/MRDnegative (31% 6 9%) and 77 MDD-negative patients (15% 6 5%) (P < .001). Five-year survival of MDD-negative and MDD-positive/ MRD-negative patients was 91% 6 3% and 92% 6 5%, respectively, compared with 65% 6 9% of MDD-positive/MRD-positive patients (P < .001). Early evaluation of MRD in NPM-ALK–positive ALCL identifies patients with a very high relapse risk andinferior survival.
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|EPrint type:||Online journal papers|
|Anno di Pubblicazione:||2014|
|More information:||Pubblicato su: BLOOD, 16 JANUARY 2014, VOLUME 123, NUMBER 3, pp. 334-337.|
|Depositato il:||11 Oct 2016 17:25|
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