Go to the content. | Move to the navigation | Go to the site search | Go to the menu | Contacts | Accessibility

| Create Account

Orazi, Marta (2008) Iperplasia prostatica e uretale in vitelli trattati con ormoni steroidei sessuali: studio sul significato patogenetico delle cellule neuroendocrine e dell'interazione stroma-epitelio. [Ph.D. thesis]

Full text disponibile come:

[img]
Preview
Documento PDF
15Mb

Abstract (english)

In beef-breading, illegal administration of sex steroid hormones with anabolic purposes is suspected as a still diffuse practice in many European countries. The continuous evolution in strategies of treatment has determined an attenuation or the disappearance of the classical ante mortem and macroscopic lesions on animals. Histopathological evaluation of bovine prostate and urethra, considered as the target organs of estrogenic and androgenic hormones, has proved to be an important method to detect the use of anabolics in bovine production with preventive implications. Typical histological lesions following to steroid hormones administration are urethral and prostatic hyperplasia and squamous metaplasia, with variable severity and distribution in relation to the specific hormone or hormones cocktail administered.
In human prostate, role of neuroendocrine (NE) cells and stromal-epithelial interaction in the pathogenesis of benign prostatic hyperplasia has been extensively analyzed.
In this study, immunoreactivity to Serotonin and Chromogranin A, considered as typical markers of NE cell, to fibroblast growth factors (FGF-2 and -7) and interleukins (IL-8 and -1a) has been evaluated on specimens of urethro-prostatic complex collected from experimentally hormones treated veal calves; moreover, it has been considered the expression of fibroblast growth factors receptors (FGF-R).
Urethral Serotonin-positive NE cells have showed to be sensitive to hormonal treatment. Also concerning stromal-epithelial interaction, prostatic expression of FGF-2, IL-8 and FGF-R has revealed a significant correlation to administration of steroid hormones. No data have been obtained about interaction between FGF-7 and IL-1a.
In conclusion, this study confirm the involvement of NE cells and stromal-epithelial interaction on the pathogenesis of bovine hormones induced prostatic and urethral hyperplasia, suggesting some important implication in evaluation of lesions in suspected treated animals.


Statistiche Download - Aggiungi a RefWorks
EPrint type:Ph.D. thesis
Tutor:Poppi, Lisa
Ph.D. course:Ciclo 20 > Scuole per il 20simo ciclo > SCIENZE VETERINARIE > SANITA' PUBBLICA VETERINARIA E PATOLOGIA COMPARATA
Data di deposito della tesi:31 January 2008
Anno di Pubblicazione:31 January 2008
Key Words:iperplasia prostatica e uretrale - vitelli - anabolizzanti - ormoni steroidei sessuali
Settori scientifico-disciplinari MIUR:Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Struttura di riferimento:Dipartimenti > pre 2012 - Dipartimento di Sanità pubblica, Patologia comparata ed Igiene veterinaria
Codice ID:969
Depositato il:09 Sep 2008
Simple Metadata
Full Metadata
EndNote Format

Bibliografia

I riferimenti della bibliografia possono essere cercati con Cerca la citazione di AIRE, copiando il titolo dell'articolo (o del libro) e la rivista (se presente) nei campi appositi di "Cerca la Citazione di AIRE".
Le url contenute in alcuni riferimenti sono raggiungibili cliccando sul link alla fine della citazione (Vai!) e tramite Google (Ricerca con Google). Il risultato dipende dalla formattazione della citazione.

1. Kroes R., Berkvens J.M., Loendersloot H.J., Ruitenberg E.G. - Oestrogen-induced changes in the genital tract of the male calf. Zbl. Vet. Med., RehiheA (1971); 18: 717-730. Cerca con Google

2. Gropp J. et al. - Effect of 17-beta-oestradiol and trenbolone acetate in different doses on several physiological and morphological parameters (provocation trial). Fortschritte in der Tierphysiologie und Tiernahrung (1976); 6: 33-52. Cerca con Google

3. Schaudinn B. et al. - Detecting the use of oestrogens in calves by histological means. Fleishwirtschaft (1977); 57(9): 1664-1668. Cerca con Google

4. Grandmontagne C. - Modifications histologiques de la prostate du veau traité par les différents anabolisants utilisés en élevage. Revue de MèdicineVeterinaire (1986) ; 137(1): 37-47. Cerca con Google

5. Groot M.J. et al. - Histological changes in the prostate of veal calves after the administration of natural hormones. Arch. Lebensmittelhyg (1990); 41: 37-42. Cerca con Google

6. Groot M.J., Ossenkoppele J.S., Bakker R., Pfaffl M.W., Meyer H.H., Nielen M.W. – Reference histology of veal calf genital and endocrine tissue – an update for screening on hormonal growth promoters. J. Vet. Med. A. Physiol. Pathol. Clin. Med. (Giugno 2007); 54 (5): 238-46. Cerca con Google

7. Groot M.J. et al. - Histological examination for detecting hormone use, a trial on veal calves. Tijdschrift voor Diergeneeskunde (1989); 114(6): 315-321. Cerca con Google

8. Groot M. J. Et al. - Changes in cytokeratine expression in accessories sex glands of growth promoter treated veal calves: influences of treatment schedule and combination of drugs. European Journal of Veterinary Pathology (2000); 6(1):19-24. Cerca con Google

9. Groot M.J., Schilt R., Ossenkoppele J.S., Berende P.L., Haasnoot W. - Combination of growth promoters in veal calves: consequences for screening and confirmatio methods. Zentralbl. Veterinarmed A. (Settembre 1998); 45(6-7): 425-40. Cerca con Google

10. Groot M.J., Biolatti B. - Histopathological effects of boldenone in cattle. J. Vet. Med. A. Physiol. Pathol. Clin. Med. (Marzo 2004); 51(2): 58-63. Cerca con Google

11. Xue Y., Smedts F., Verhofstad A., Debruyne F., De la Rosette J., Schalken J. - Cell kinetics of prostate exocrine and neuroendocrine epithelium and their differential interrelationship : new perspectives. Prostate Suppl. (1998); 8: 62-73. Cerca con Google

12. Peehl D.M. - Cellular biology of prostatic growth factors. Prostate Suppl. (1996); 6: 74-8. Cerca con Google

13. Bonkhoff H., Remberger K. - Differentiation pathways and histogenetic aspects of normal and Cerca con Google

abnormal prostatic growth: a stem cell model. Prostate (Febbraio 1996); 28(2): 98-106. Cerca con Google

14. Xue Y., Smedts F., Debruyne F., De la Rosette J., Schalken J. - Identification of intermediate cell types by keratin expression in the developing human prostate. Prostate (1998); 34: 292-301. Cerca con Google

15. Abraham T.K., Cockett M.D., P. Anthony Di Sant’Agnese M.D., Prabhu Gopinath D., Susan R. Schoen B.S., P. A. Abrahamsson M.D. - Relationship of neuroendocrine cells of prostate and serotonin to benign prostatic hyperplasia. Urology (Novembre 1993); 42(5): 512-19. Cerca con Google

16. Islam M.A., Kato H., Hayama M., Kobayashi S., Igawa Y., Ota H., Nishizawa O. – Are neuroendocrine cells responsible for the development of benign prostatic hyperplasia? Eur. Urol. (Agosto 2002); 42(2): 79-83. Cerca con Google

17. Aumuller G., Leonhardt M., Renneberg H., Von Rahden B., Bjartell A., Abrahamsson P.A. - Semiquantitative morphology of human prostatic development and regional distribution of prostatic neuroendocrine cells. Prostate (Febbraio 2001); 46(2): 108-15. Cerca con Google

18. Armen G. Aprikian, Carlos Cordon-Cardo, William R. Fair, Victor E. Reuter - Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma. Cancer (Giugno 1993); 71(12): 3952-65. Cerca con Google

19. Giri D., Ittmann M. - Interleukin-8 is a paracrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic hyperplasia. American Journal of Pathology (Luglio 2001); 159(1): 139-147. Cerca con Google

20. Giri D., Ittmann M. - Interleukin-1??is a paracrine inducer of FGF7, a key epithelial growth factor in benign prostatic hyperplasia. American Journal of Pathology (Luglio 2000); 157(1): 249- 55. Cerca con Google

21. Ropiquet F., Giri D., Lamb D.J., Ittmann M. - FGF7 and FGF2 are increased in benign prostatic hyperplasia and are associated with increased proliferation. J. Urol. (Agosto 1999); 162(2): 595-9. Cerca con Google

22. Matsubara A. - Studies on the mechanism of action of fibroblast growth factors in stromal cells in hyperplastic human prostate. Nippon Hinyokika Gakkai Zasshi (Maggio 1995); 86(5): 1034-43. Cerca con Google

23. Xue Y., Van der Laak J., Smedts F., Schoots C., Verhofstad A., De la Rosette J., Schalken J. - Neuroendocrine cells during human prostate development: does neuroendocrine cell density remain constant during fetal as well as postnatal life? Prostate (2000); 42: 116-123. Cerca con Google

24. Arrighi S., Cremonesi F., Bosi G., Domeneghini C. - Endocrine-paracrine cells of the male urogenital apparatus: a comparative histochemical and immunohistochemical study in some domestic ungulates. Anat. Histol. Embryol. (Agosto 2004); 33(4): 225-32. Cerca con Google

25. Arrighi S., Domeneghini C. - Immunolocalization of regulatory peptides and 5-HT in bovine male urogenital apparatus. Histology and Histopathology (1998); 13: 1049-1059. Cerca con Google

26. Provincia Autonoma di Bolzano-Alto Adige - Circolare n. 30 del 17.10.2006. Cerca con Google

27. Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche - Webzine Sanità Pubblica Veterinaria (Novembre 2006); n. 38. [www.spvet.it]. Vai! Cerca con Google

28. Barone R. - Anatomia comparata degli animali domestici – Ghiandole annesse all’uretra. Vol. IV (1994); Ed. Edagricole, Bologna. Cerca con Google

29. Bruni A.C., Zimmer U. - Anatomia degli animali domestici – Apparato genitale maschile. Vol. II (1992); Società Editrice Libraria, Milano. Cerca con Google

30. Nickel R., Schummer A., Seiferle E. - Trattato di anatomia degli animali domestici – Apparato genitale: organi genitali maschili. Vol. II (1975); Casa Editrice Ambrosiana, Milano. Cerca con Google

31. Dellman H.D., Brown E.M. - Istologia ed anatomia microscopica veterinaria – Apparato genitale maschile: ghiandole annesse. Editoriale Grasso, Bologna (1981). Cerca con Google

32. Veggetti A. - Corso di embriologia – Apparato genitale. Società Editrice Esculapio, Bologna (1987). Cerca con Google

33. Biolatti B., Cabassi E., Rosmini R., Groot M.J., Castagnaro M. et al. - Lo screening istologico nella prevenzione dell’uso di anabolizzanti nel bovino. Large Animal Review (2003); 2: 9-15. Cerca con Google

34. Boatto G., Culeddu N., Testa C., Neri B., Brambilla G., Barbosa J., Cruz C. - Identification of a probable new adrenergic agonist by nuclear magnetic resonance and mass spectrometry. Anal. Chim. Acta (Marzo 2007); 586 (1-2): 223-7. Cerca con Google

35. Avendano-Reyes L., Torres-Rodriguez V., Meraz-Murillo F.J., Perez-Linares C., Figueroa- Saavedra F., Robinson P.H. - Effects of two beta-adrenergic agonists on finishing performance, carcass characteristics and meat quality of feedlot steers. J. Anim. Sci. (Dicembre 2006); 84(12): 3259-65. Cerca con Google

36. Le Bizec B., Van Hoof N., Courtheyn D., Gaudin I., Van De Wiele M., Bichon E., De Brabander H., André F. - New anabolic steroid illegally used in cattle-structure elucidation of 19- norchlorotestosterone acetate metabolites in bovine urine. J. Steroid Biochem Mol. Biol. (Gennaio 2006); 98(1): 78-89. Cerca con Google

37. Darsiè G., Rosmini R. - La tecnica di prelievo della ghiandola prostatice e delle ghiandole di Bartolino in vitelli presumibilmente trattati con estrogeni di sintesi. Riv. Zoot. Vet. (1979); 5: 315- 320. Cerca con Google

38. Groot M.J. - Histological screening for illegal administration of growth promoting agents in veal calves (1992). Cerca con Google

39. Luppi A. - Istopatologia di ghiandole-organi-tessuti ormono-dipendenti nei bovini. Atti Soc. It. Buiatria (1986); 18: 163-167. Cerca con Google

40. Luppi A, Gianfaldoni D., Gilioli G., Del Bono G. - Contributo alla diagnostica degli anabolizzanti. Nota II: significato diagnostico di alcuni rilievi anatomo-istologici di ghiandole ormonodipendenti. Il Nuovo Progresso Veterinario (1992); 47: 201-204. Cerca con Google

41. Cannizzo F.T., Zancanaro G., Spada F., Mulasso C., Biolatti B. - Pathology of the testicle and sex accessory glands following the administration of boldenone and boldione as growth promoters in veal calves. J. Vet. Med. Sci. (Novembre 2007); 69(11): 1109-16. Cerca con Google

42. Balboni G.C., Bastianini A. et al. - Anatomia umana. Editrice Edi-Ermes (1991): 453-458. Cerca con Google

43. Rubin E., Farber J.L. - Atlante di patologia sistematica e generale. Editrice McGraw-Hill (1991): 428. Cerca con Google

44. Rubin E., Farber J.L. - Patologia sistematica e generale – Il tratto urinario e l’apparato genitale maschile. Ed. McGraw-Hill (1991): 547-548. Cerca con Google

45. Wheater, Burkitt, Daniels - Istologia e anatomia microscopica. Editrice Ambrosiana (1988): 286- 288. Cerca con Google

46. Rubin E., Farber J.L. - Patologia sistematica e generale – Il tratto urinario e l’apparato genitale maschile. Ed. McGraw-Hill (1991): 549-550. Cerca con Google

47. Shapiro E., Hartanto V., Perlman E., Tang R., Wang B., Lepor H. - Morphometric analysis of pediatric and nonhyperplastic glands: evidence that BPH is not a unique stromal process. Prostate (1997); 33: 177-182. Cerca con Google

48. Herrero M., Rodriguez A., Cejas H. - Prostatic neuroendocrine cells. Rev. Fac. Cien. Med. Univ. Nac. Cordoba (2002); 59(1): 91-6. Cerca con Google

49. Abrahamsson P.A. - Neuroendocrine differentiation and hormone-refractory prostate cancer. Prostate Suppl. (1996); 6: 3-8. Cerca con Google

50. Pretl K. - Zur frage der endokrinie der menschilchen vorsteherdruse. Virchows Arch. (1944); 312: 392-404. Cerca con Google

51. Schalken J.A., Leenders G. - Cellular and molecular biology of the prostate: stem cell biology. Urology (2003); 6 (5 Suppl. 1): 11-20. Cerca con Google

52. Xue Y., Verhofstad A., Lange W., Smedts F., Debruyne F., De la Rosette J., Schalken J. - Prostatic neuroendocrine cells have a unique keratin expression pattern and do not express Bcl-2 : cell kinetic features of neuroendocrine cells in the human prostate. American Journal of Pathology (Dicembre 1997); 151(6): 1759-65. Cerca con Google

53. Bonkhoff H., Stein U., Remberger K. - Multidirectional differentiation in the normal, hyperplastic and neoplastic human prostate: simultaneous demonstration of cell-specific epithelial markers. Hum. Pathol. (1994); 25: 42-46. Cerca con Google

54. Abrahamsson P.A., Wadstrom L.B., Alumets J., Falkmer S., Grimelius L. - Peptide- hormoneand serotonin-immunoreactive cells in normal and hyperplastic prostate glands. Pathol. Res. Pract. (Dicembre 1986); 181(6): 675-83. Cerca con Google

55. Di Sant’Agnese P.A., De Mesy Jensen K.L., Churukian C.J., Agarwal M.M. – Human prostatic endocrine-paracrine (APUD) cells. Distributional analysis with a comparison of serotonin and neuron-specific enolase immunoreactivity and silver stains. Arch. Pathol. Lab. Med. (Luglio 1985); 109(7): 607-12. Cerca con Google

56. Bonkhoff H., Wernert N., Dhom G., Remberger K. - Relation of endocrine-paracrine cells to cell proliferation in normal, hyperplastic and neoplastic human prostate. Prostate (1991); 19: 91- 98. Cerca con Google

57. Bonkhoff H., Stein U., Remberger K. - Endocrine-paracrine cell types in the prostate and prostatic adenocarcinoma are postmitotic cells. Human Pathol. (1995); 26: 167-170. Cerca con Google

58. Vittoria A., Cocca T., La Mura E., Cecio A. - Immunocytochemistry of paraneurons in the female urethra of the horse, cattle, sheep and pig. Anatomy Records (1992); 233: 18-24. Cerca con Google

59. Cecio A., Vittoria A. - Urogenital paraneurons in several mammals. Arch. Histol. Cytol. (1989); Cerca con Google

52 Suppl.: 403-13. Cerca con Google

60. Cetyn Y. - Chromogranin A immunoreactivity and Grimelius’ argirophilia. A correlative study in mammalian endocrine cells. Anat. Embryol. (1992); 185(3): 207-15. Cerca con Google

61. Planz B., Aretz H.T., Wang Q., Tabatabaei S., Kirley S.D., Lin C.W., McDougal W.S. - Immunolocalization of the keratinocyte growth factor in benign and neoplastic human prostate and its relation to androgen receptor. Prostate (Dicembre 1999); 41(4): 233-42. Cerca con Google

62. Polnaszek N., Kwabi-Addo B., Wang J., Ittman M. - FGF-17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia. Prostate (Giugno 2004); 60(1): 18-24. Cerca con Google

63. Nakano K., Fukabori Y., Itoh N., Lu W., Kan M., McKeehan W.L., Yamanaka H. - Androgen- stimulated human prostate epithelial growth mediated by stromal-derived fibroblast growth factor- 10. Endocr. J. (Giugno 1999); 46(3): 405-13. Cerca con Google

64. Smith P., Rhodes N.P., Ke Y., Foster C.S. - Upregulation of estrogen and androgen receptors modulate expression of FGF-2 and FGF-7 in human, cultured, prostatic stromal cells exposed to high concentrations of oestradiol. Prostate Cancer Prostatic Dis. (2002); 5(2): 105-10. Cerca con Google

65. Steiner M.S. - Role of peptide growth factors in the prostate – a review. Urology (1993); 42: 99-100. Cerca con Google

66. Deshmukh N. et al. - Differential expression of acidic- and basic- fibroblast growth factors in benign prostatic hyperplasia identified by immunohistochemistry. Br. J. Urol. (1997); 80: 869-874. Cerca con Google

67. Saez C. et al. - Expression of basic fibroblast growth factor and its receptors FGF-R1 and FGF-R2 in human benign prostatic hyperplasia treated with finasteride. Prostate (1990); 40: 83- 88. Cerca con Google

68. Sherwood E.R. et al. - Basic fibroblast growth factor. A potential mediator of stromal growth in the human prostate. Endocrinology (1992); 130: 2955-2963. Cerca con Google

69. Boget S., Cereser C., Parvaz P., Leriche A., Revol A. - Fibroblast growth factor receptor 1 (FGFR1) is over-expressed in benign prostatic hyperplasia whereas FGFR2-IIIc and FGFR3 are not (Clinical study). European Journal of Endocrinology (2001); 145: 303-310. Cerca con Google

70. Story M.T., Hopp K.A., Molter M., Meier D.A. - Characteristics of FGF-receptors expressed by stromal and epithelial cells cultured from normal and hyperplastic prostates. Growth Factors (1994); 10(4): 269-80. Cerca con Google

Download statistics

Solo per lo Staff dell Archivio: Modifica questo record